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PO:21:028 | A difficult case of VEXAS syndrome: management of myelodysplastic syndrome associated with systemic inflammation and infectious complications Sandra Lombardi1, Monica Regis1, Stefano De Luca1, Monica Poiani2, Rossella Stella2, Elisa Lucchini2, Francesco Zaja2, Fabio Fiammengo1 | 1SC Medicina Interna, Azienda Sanitaria Universitaria Giuliano Isontina, Gorizia; 2SC Ematologia, Azienda Sanitaria Universitaria Giuliano Isontina, Trieste, Italy
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PO:24:064 | IPF vs CTD-ILD: Survival and Lung Function from an Italian Real-World Cohort Marco Fornaro1, Donato Lacedonia2, Lorenzo Cavagna3, Paolo Airò4, Marco Sebastiani5, Gianluca Sambataro6, Fabio Cacciapaglia7, Angelica Napoletano1, Cosimo De Pace2, Pasquale Tondo2, Giulia Scioscia2, Eleonora Pedretti4, Maria Grazia Lazzaroni4, Carlo Vancheri8, Andreina Manfredi9, Lorenzo Binchessi3, Rocco Capece3, Michele De Ceglie10, Massimo Giotta11, Florenzo Iannone1 | 1Unit of Rheumatology, Department of Precision and Regenerative Medicine - Area Jonica DiMePRe-J, University of Bari, Bari, Italy; 2Department of Medical and Surgical Sciences, University of Foggia Foggia, Italy; 3Department of Internal Medicine and Therapeutics, University of Pavia, Division of Rheumatology, Fondazione IRCCS, Pavia, Italy; 4Rheumatology and Clinical Immunology Unit, Department of Clinical and Experimental Sciences, ASST Spedali Civili Brescia, Italy; 5Rheumatology Unit, AUSL Piacenza, Department of Medicine and Surgery, University of Parma, Parma, Italy; 6Department of Medicine and Surgery, University of Enna Kore, Enna, Italy; 7Rheumatology Service, F. Miulli Hospital and Department of Medicine and Surgery, LUM University, Casamassima, Italy; 8Department of Clinical and Experimental Medicine, Regional Referral Center for Rare Lung Diseases, Catania, Italy; 9Rheumatology Unit, IRCCS Santa Maria Nuova Reggio Emilia, University of Modena, Modena, Italy; 10DIM, Interdisciplinary Department of Medicine, Section of Diagnostic Imaging, University of Bari, Bari, Italy; 11Health Prevention Department, Local Health Authority of Brindisi, Brindisi, Italy
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CO:08:6 | Prevalence, incidence and survival in interstitial lung disease secondary to primary Sjögren’s syndrome. Results from the “EMERGE” longitudinal study Alessandra Rai1, Caterina Vacchi2, Stefania Cerri3, Roberta Eufrasia Ledda4, Giulia Cassone2, Dario Andrisani3, Filippo Gozzi3, Lucia Dardani1, Fabiola Atzeni5, Athina Patsoura3, Francesca Cozzini1, Marco Sebastiani6, Andreina Manfredi1. | 1USL-IRCCS Reggio Emilia, University of Modena and Reggio Emilia; 2Azienda Ospedaliero Universitaria Policlinico di Modena; 3 Pulmonology Unit, AOU Policlinico di Modena, University of Modena and Reggio Emilia; 4Radiology Unit, Azienda Ospedaliera di Parma, University of Parma; 5 Policlinico Gaetano Martino, University of Messina; 6Azienda Ospedaliera di Piacenza,University of Parma, Italy
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PO:24:068 | Case Report: ‘Spontaneous Pneumomediastinum in a Patient with MDA5-Positive Dermatomyositis and Severe Pulmonary Fibrosis’ Carlotta Braga1, Margherita Rizzo1, Marta Raschellà1, Beatrice Maranini1, Gioacchino Schifino2, Aldo Carnevale3, Marcello Govoni1, Andrea Lo Monaco1 | 1Rheumatology Unit, Department of Medical Sciences, University of Ferrara and Azienda Ospedaliero-Universitaria S. Anna Ferrara, Italy; 2Respiratory Medicine Unit, Department of Cardio-Thoracic-Vascular Pathologies, Arcispedale Sant'Anna, Ferrara, Italy; 3Radiology Unit, Department of Translational Medicine, University of Ferrara, Italy
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PO:31:172 | Age and timing of onset of Raynaud's phenomenon and first non-Raynaud sign/symptom as prognostic factors in systemic sclerosis: a retrospective analysis from the systemic sclerosis progression investigation registry of the Italian Society for Rheumatology Silvia Peretti1, Cosimo Bruni2, Silvia Laura Bosello3, Fabio Cacciapaglia4-5, Corrado Campochiaro6-7, Veronica Codullo8, Lorenzo Dagna6-7, Rossella De Angelis9, Giacomo De Luca6-7, Dilia Giuggioli10, Serena Guiducci1, Florenzo Iannone4, Francesca Ingegnoli11, Valeria Riccieri12, Marco Matucci Cerinic6-7, Clodoveo Ferri10-13, Silvia Bellando Randone1. | 1Division of Rheumatology, Scleroderma Unit, Department of Experimental and Clinical Medicine, University of Florence, AO, Firenze, Italy; 2Division of Rheumatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland; 3Rheumatology Division, Catholic University of the Sacred Heart, Fondazione Policlinico Universitario A. Gemelli- IRCCS, Roma, Italy; 4Rheumatology Unit, Department of Precision and Regenerative Medicine-Ionian Area, University of Bari Aldo Moro, Bari, Italy; 5Reumatology Service, Internal Medicine Unit F.Miulli General Hospital, Acquaviva delle Fonti -Department of Medicine a, Bari, Italy; 6Unit of Immunology, Rheumatology, Allergy and Rare Diseases UnIRAR, Inflammation, Fibrosis and Ageing initiative INFL, Milano, Italy; 7Vita-Salute San Raffaele University, Milano, Italy; 8Department of Internal Medicine and Therapeutics, Università di Pavia, Italy; Division of Rheumatology, Fondazione IRCCS, Pavia, Italy; 9Rheumatology Unit, Department of Clinical and Molecular Sciences, Polytechnic University of Marche, Ancona, Italy; 10Rheumatology Unit, School of Medicine, University of Modena and Reggio Emilia, Modena, Italy; 11Division of Clinical Rheumatology, ASST Pini, Dept. of Clinical Sciences and Community Health, Research Center for Adul, Milano, Italy; 12Department of Rheumatology, Sapienza University of Rome, Roma, Italy; 13Rheumatology Clinic Madonna dello Scoglio Crotonei, Crotone, Italy.
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PO:32:178 | Effectiveness of oral anticoagulants in precapillary pulmonary hypertension associated with systemic sclerosis: a EUSTAR cohort study Nicola Farina1, Silvia Bellando-Randone1, Hilde Jenssen-Bjørkekjær2, David Launay3, Patricia Carreira4, Paolo Airò5, Serena Guiducci1, Dilia Giuggioli6, Gabriela Riemekasten7, Carmen-Pilar Simeón Aznar8, Christina Bergmann9, Elise Siegart10, Ivan Castellví11, Lesley Ann Saketkoo12, Jeska De Vries-Bouwstra13, Philipp Klemm14, Ulf Müller-Ladner14, Alexandra Balbir-Gurman15, Vanessa Smith16, Florenzo Iannone17, Luca Idolazzi18, Christopher Denton19, Edoardo Rosato20, Britta Maurer1, Yannick Allanore1, Yoshiya Tanaka1, Elisabetta Zanatta1, Oliver Distler1, Marco Matucci-Cerinic1, Cosimo Bruni1 | 1Department of Experimental and Clinical Medicine, Scleroderma Unit, Division of Rheumatology, University of Florence, Az Firenze, Italy; 2Department of Rheumatology, Hospital of Southern Norway Kristiansand, Norway; 3National Reference Center for Pulmonary Arterial Hypertension Pulmotension Lille, France; 4Hospital Universitario 12 de Octubre, Rheumatology Department Madrid Spain; 5ASST Spedali Civili of Brescia, University of Brescia, Rheumatology and Clinical Immunology Unit Brescia, Italy; 6Scleroderma Unit, Rheumatology Unit, University Hospital of Modena and Reggio Emilia Modena, Italy; 7Universitätsklinikum Schleswig-Holstein, Klinik für Rheumatologie und klinische Immunologie Lübeck Germany; 8Hospital Universitario Vall d'Hebron, Department of Internal Medicine, Systemic Autoimmune Diseases Unit Barcelona Spain; 9University Hospital Erlangen, Department Internal Medicine 3 Erlangen Germany; 10Charité University Hospital, Department of Rheumatology Berlin Germany; 11Hospital de la Santa Creu i Sant Pau Baercelona Spain; 12New Orleans Scleroderma and Sarcoidosis Patient Care and Research Center New Orleans, USA; 13Leiden University Medical Center, Department of Rheumatology Leiden, The Netherlands; 14JLU Giessen, Campus Kerckhoff, Department of Rheumatology and Clinical Immunology Center Bad Nauheim Germany; 15Rambam Health Care Campus, Rheumatology Institute Haifa, Israel; 16University of Ghent, Department of Rheumatology Ghent, Belgium; 17Rheumatology DiMePReJ, University of Bari, School of Medicine Bari, Italy; 18University of Verona, Section of Rheumatology, Department of Medicine Verona, Italy; 19Royal Free London and University College London Medical School, Centre for Rheumatology London, United Kingdom; 20Sapienza University of Rome, Department of Translational and Precision Medicine Azienda Ospedaliero-Universitaria Policl Roma, Italy
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PO:16:226 | Clinical Phenotypes of Systemic Lupus Erythematosus: An Exploratory Cluster Analysis in a Monocentric Cohort Richard Borrelli1, Stefania Nicola1, Federica Corradi1, Iuliana Badiu1, Luca Lo Sardo1, Marzia Boem1, Valentina Marmora1, Simone Negrini1, Luisa Brussino1 | 1SCDU Immunologia e Allergologia, AO Mauriziano, Dipartimento di Scienze Mediche, Università degli Studi di Torino, Italy
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CO:03:3 | Contribution of mitochondrial DNA to the onset and maintenance of inflammation in Systemic Sclerosis patients Martina Orlandi1, Giorgia Sinigaglia2, Amelia Spinella1, Isabella Martusciello2, Marco De Pinto1, Giorgia Roveta1, Luca Keller1, Marcello Pinti2, Dilia Giuggioli1 | 1Dipartimento di scienze mediche e chirurgiche dei bambini e degli adulti, Università di Modena e Reggio Emilia, Italy; 2Università degli Studi di Modena e Reggio Emilia, Italy
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PO:31:168 | Risk factors for cancer in systemic sclerosis, impact on disease phenotype and prognosis, and proposal of machine learning-based personalized screening strategies: insights from an EUSTAR study Antonio Tonutti1|2, Francesca Motta1|2, Stefano Erba1|2, Britta Maurer3, Cristiana Sieiro Santos3, Duygu Temiz Karadag3, Elena Rezus3, Elisabetta Zanatta3, Fabiola Atzeni3, Francesco Benvenuti3, Gabor Kumanovics3, Gabriella Szucs3, Gianluca Moroncini3, Gonçalo Boleto3, Leila Caillault3, Lilian Maria Lopez Nunez3, Masataka Kuwana3, Massimiliano Limonta3, Maurizio Cutolo3, Oliver Distler3, Radim Bevcar3, Roberto Giacomelli3, Rossella De Angelis3, Serena Guiducci3, Stefano Stano3, Valeria Riccieri3, Yasser El Miedany3, Sophie Blaise3, Carlo Selmi1|2, Maria De Santis1|2 | 1Department of Biomedical Sciences, Humanitas University Pieve Emanuele, Milan, Italy; 2Rheumatology and Clinical Immunology, IRCCS Humanitas Research Hospital Rozzano, Milan, Italy; 3EUSTAR collaborators EUSTAR * OTHER
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PO:31:166 | S'/PAPs ratio in systemic sclerosis: a promising non-invasive index for early detection and prognosis of pulmonary hypertension. A step toward more accurate screening? Marco De Pinto1, Amelia Spinella1, Pierluca Macripò2, Alessia Laneri1, Benedetta Bongiovanni1, Maria Grazia Malandra1, Martina Orlandi1-3, Gianluca Pagnoni2, Arianna Maini2, Rosario Rossi2-4, Clodoveo Ferri1, Francesca Coppi2-3, Dilia Giuggioli1-3. | 1Rheumatology Unit, Azienda Ospedaliero-Universitaria Policlinico di Modena, University of Modena and Reggio Emilia, Modena, Italy; 2Cardiology Division, Azienda Ospedaliero-Universitaria Policlinico di Modena, Modena, Italy; 3Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia, Modena, Italy; 4Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy.
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PO:12:186 | Clinical, functional, and microvascular features in the early diagnosis and management of pulmonary hypertension in systemic sclerosis: the importance of multimodal screening strategies Irene Carlino1, Stefania Bisogno1, Alberto Palazzuoli2, Luigi Gennari1 | 1U.O.C. Reumatologia, Dipartimento di Scienze Mediche, Chirurgiche e Neuroscienze, Università di Siena, A.O.U. Senese; 2Azienda Sanitaria Locale, Novara, Italy
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PO:35:222 | Distinctive Features of Localized Vasculitis of the Gastrointestinal Tract Compared to Takayasu Arteritis: Insights from a Multicenter Cohort Study Vittorio Dibenedetto1|2|3, Alessandro Tomelleri1|2, Corrado Campochiaro1|2, Elena Baldissera1|2, Luca Moroni1|2, Padoan Roberto4, Marco Matucci-Cerinic1|2|3, Lorenzo Dagna1|2|3 | 1Unit of Immunology, Rheumatology, Allergy and Rare Diseases UNIRAR, IRCCS San Raffaele Hospital Milan, Italy; 2Inflammation, Fibrosis and Ageing Intitiative INFLAGE, IRCCS San Raffaele Hospital Milan, Italy; 3Vita-Salute San Raffaele University, Milan, Italy Milan, Italy; 4University Hospital of Padova, Department of Internal Medicine and Rheumatology Padova, Italy
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PO:36:251 | Rheumatoid factor predicts vasculitis relapse in eosinophilic granulomatosis with polyangiitis: a machine learning approach Luca Iorio1, Federica Davanzo1, Giulia Lorenzoni2, Eleonora Fiorin1, Marta Codirenzi1, Roberta Prevedello1, Debora Campaniello1, Dario Gregori2, Roberto Padoan1, Andrea Doria1. | 1Rheumatology Unit, DIMED, University of Padova, Padova, Italy; 2Unit of Biostatistics, Epidemiology and Public Health, DCTV, University of Padova, Padova, Italy.
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PO:37:267 | Mimickers of polyarteritis nodosa: a case of segmental arteriolar mediolysis Filippo Santoro1, Caterina Vacchi2, Giulia Cassone2, Maria Grazia Malandra1, Dilia Giuggioli1|2 | 1UOSD Reumatologia, Ospedale San Camillo De Lellis, Rieti; 2UOC Igiene e Sanità Pubblica, ASL Rieti; 3Direzione Sanitaria, ASL Rieti, Italy
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CO:06:3 | Clinical and laboratory markers for distinguishing VEXAS from Schnitzler's syndrome in male patients with skin involvement: insights from the International AIDA Network Registries Valeria Caggiano1, Jessica Sbalchiero1, Micol Frassi2, Andrea Hinojosa-Azaola3, Francesca Crisafulli2, Franco Franceschini2, Paolo Sfriso4, Sara Bindoli4, José Hernández-Rodríguez5, Henrique A. Mayrink Giardini6, Giuseppe Lopalco7, Florenzo Iannone7, Ombretta Viapiana8, Amato De Paulis9, Lorenzo Dagna10, Antonio Gidaro11, Serena Bugatti12, Matteo Piga13, Fabrizio Conti14, Rosetta Vitetta15, Cecilia Chighizola16, Marcello Govoni17, Giacomo Emmi18, Paola Triggianese19, Carmelo Gurnari19, Bruno Frediani1, Claudia Fabiani1, Luca Cantarini1, Antonio Vitale1, for the AIDA Network1 | 1Department of Medical Sciences, Surgery and Neurosciences, University of Siena; 2University of Brescia, Italy; 3Department of Immunology and Rheumatology, Mexico City, Mexico; 4Rheumatology Unit, University of Padova, Italy; 5Clinical Unit of Autoinflammatory Diseases, Hospital Clínic of Barcelona, Spain; 6Rheumatology Division, Universidade de São Paulo, Brazil; 7University of Bari; 8Rheumatology Unit, University and Azienda Ospedaliera Universitaria Integrata of Verona; 9University of Napoli "Federico II"; 10Università Vita-Salute San Raffaele, Milano; 11Luigi Sacco Hospital, University of Milano; 12Università di Pavia; 13University and AOU of Cagliari; 14AOU Policlinico Umberto I, Sapienza University of Rome; 15Unit of Rheumatology, ASL Sant' Andrea Hospital, Vercelli; 16University of Milano; 17Azienda Ospedaliero-Universitaria S. Anna, Ferrara; 18University of Trieste; 19University of Rome-Tor Vergata, Rome, Italy.
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PO:31:161 | First-line diagnostic tests to intercept primary heart involvement in systemic sclerosis: clinical associations from the SPRING-SIR registry Antonio Tonutti1|2, Francesca Motta1|2, Rossella De Angelis3, Valeria Riccieri4, Silvia Laura Bosello5, Fabio Cacciapaglia6, Veronica Codullo7, Giacomo De Luca8, Francesca Ingegnoli9, Dilia Giuggioli10, Clodoveo Ferri10, Marco Matucci-Cerinic8, Carlo Selmi1|2, Maria De Santis1|2 | 1Department of Biomedical Sciences, Humanitas University Pieve Emanuele, Milan, Italy; 2Rheumatology and Clinical Immunology, IRCCS Humanitas Research Hospital Rozzano, Milan, Italy; 3Università Politecnica delle Marche Ancona, Italy; 4Università degli Studi di Roma La Sapienza Roma, Italy; 5Università Cattolica del Sacro Cuore Roma, Italy; 6Università degli Studi di Bari Aldo Moro Bari, Italy; 7Reumatologia, Fondazione IRCCS Policlinico San Matteo Pavia, Italy; 8Università Vita-Salute San Raffaele Milano, Italy; 9Università degli Studi di Milano, Italy; 10Università degli Studi di Modena e Reggio Emilia, Italy
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PO:33:195 | Evaluation of prevalence and role of anti-endothelin type a-receptor and anti-angiotensin ii type 1-receptor antibodies in a cohort of systemic sclerosis patients Clara Minerba1, Sara Ferrigno1, Antonella Grimaldi2, Noemi Aprile3, Daniela Costanza2, Laura Quarta2, Maria Rita Ricciardi2, Daniela Stasi3, Paola Conigliaro1, Alberto Bergamini1, Eugenio Quarta2, Maria Sole Chimenti1. | 1U.O.C. Reumatologia, Dipartimento di Medicina dei Sistemi, Università di, Roma, Tor Vergata, Roma, Italy; 2U.O.S.D. Reumatologia, P.O. Vito Fazzi Lecce Italy; 3U.O.C. Patologia clinica e Microbiologia, P.O. Vito Fazzi Lecce Italy.
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PO:11:165 | Clinical mimicry and therapeutic challenge: A Case of Rapidly Progressive Mixed Connective Tissue Disease Elena Maria Di Virgilio1, Elisabetta Chessa2, Valentina Ibba2, Cosimina Matulli2, Jessica Sorgia1, Andrea Pace1, Matteo Piga1|2, Alberto Cauli1|2 | 1Università degli studi di Cagliari-Reumatologia, Cagliari, Italy; 2Struttura complessa di Reumatologia- AOU Cagliari, Cagliari, Italy
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CO:05:1 | Predicting one-year disease activity in systemic lupus erythematosus using machine learning and explainable AI Pier Giacomo Cerasuolo1, Augusta Ortolan1, Livia Lilli2, Laura Antenucci2, Carlotta Maschiocchi2, Jacopo Lenkowicz2, Lucia Lanzo1, Luca Petricca1, Maria Rita Gigante1, Vivianaantonella Pacucci1, Pierluigi Rizzuti1, Rebecca Ventura1, Silvia Piunno1, Cesare Gavotti1, Marco Gorini3, Gabriella Castellino3, Alfredo Cesario2, Stefano Patarnello2, Silvia Laura Bosello1, Maria Antonietta D'Agostino1. | 1UOC di Reumatologia ed Immunologia Clinica, Fondazione Policlinico A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Roma; 2Gemelli Generator, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma; 3AstraZeneca Italy, MIND, Milano, Italy
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PO:25:085 | Anti-MDA5 antibody syndrome, a life-threatening condition for rheumatologist and pulmonologist A case series Francesca Cozzini1|2, Cecilia Burattini1, Elena Bravi1, Chiara Nani1, Eugenio Arrigoni1, Fabia Cavallotti1, Ilaria Platè1, Marco Sebastiani1|3 | 1Ospedale Guglielmo da Saliceto Piacenza, Italy; 2Università degli studi di Modena e Reggio Emilia, Italy; 3Università degli Studi di Parma, Italy
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PO:24:070 | Preliminary descriptive data from a single-centre cohort of patients with idiopathic inflammatory myopathy: focus on paraneoplastic and non-paraneoplastic patients Silvia Ebe Lucia Della Pina1, Paola Bizioli1, Samantha Mazza2, Caproli Alessia1, Cesare Tomasi1, Ilaria Cavazzana1, Franco Franceschini1. | 1S.C.O. Reumatologia ed Immunologia Clinica, ASST Spedali Civili di Brescia, Università degli Studi di Brescia, Brescia, Italy; 2Università degli Studi di Brescia, Brescia, Italy.
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CO:08:5 | Clinical impact of anti-Ro52 antibodies in idiopathic inflammatory myopathies: insights from a multicenter Italian cohort Paola Bizioli1, Cesare Tomasi2, Francesca Bellisai3, Francesca Buzzulini4, Antonio Tonutti5|6, Angela Ceribelli5|6, Edoardo Conticini3, Anna Ghirardello7, Luca Iaccarino7, Danilo Villalta4, Franco Franceschini1, Ilaria Cavazzana1. | 1Rheumatology and Clinical Immunology Unit - ERN ReCONNET, ASST Spedali Civili of Brescia; 2Department of Clinical and Experimental Sciences, University of Brescia; 3Department of Medicine, Surgery and Neurosciences, Rheumatology Unit, University of Siena; 4Department of Laboratory Immunology and Allergology, Santa Maria degli Angeli Hospital, Pordenone; 5Department of Biomedical Sciences, Humanitas University, Rozzano (MI); 6Rheumatology and Clinical Immunology, Istituti di Ricovero e Cura a Carattere Scientifico, Humanitas Research Hospital, Rozzano (MI); 7Division of Rheumatology, Department of Medical and Surgical Sciences, University of Padova, Italy
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PO:26:088 | Rheumatologic immune-related adverse events from immune checkpoint inhibitors: a monocentric retrospective study Giulio Fraticelli1|2, Nicola Farina1|2, Alessandro Tomelleri1|2, Marco Matucci Cerinic1|2, Corrado Campochiaro1|2, Lorenzo Dagna1|2. | 1Unit of Immunology, Rheumatology, Allergy and Rare Diseases UNIRAR, IRCCS San Raffaele Hospital, Milano, Italy; 2Inflammation, Fibrosis and Ageing Initiative INFLAGE, IRCCS San Raffaele Hospital, Milano, Italy.
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