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PO:15:219 | Nailfold capillaroscopic abnormalities in systemic lupus erythematosus: comparison with healthy controls and clinical-immunological correlations. Preliminary data Chiara Orlandi1|2, Alessia Loda2, Cesare Tomasi1|2, Silvia Ebe Lucia Della Pina1|2, Claudia Barison1|2, Cecilia Nalli1, Ilaria Cavazzana1|2, Micaela Fredi1|2, Franco Franceschini1|2. | 1Rheumatology and Clinical Immunology Unit - ERN ReCONNET , ASST Spedali Civili of Brescia, Brescia, Italy; 2Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
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PO:30:160 | A rare case of juvenile systemic sclerosis Marta Arese1|2, Francesco Baldo3, Stefania Costi3, Achille Marino3, Cecilia Chighizola1|3, Roberto Felice Caporali1|2 | 1Azienda Ospedaliera Universitaria Senese, Università degli Studi di Siena; 2Reumatologia Clinica, ASST Gaetano Pini-CTO, Milano, Italy
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PO:31:163 | Safety and tolerability of home-based prostacyclin analogue therapy in vascular manifestations of the scleroderma spectrum: results of a monocentric study Alice Dionisi1, Lucrezia Verardi2, Annacarla Finucci2, Paola Volpe2, Anna Cinzia Raspa2, Paola Cipriani1, Raffaele Zicolella2 | 1Reumatologia,Dipartimento di Sscienze Cliniche Applicate e Biotecnologiche, Università degli Studi dell'Aquila; 2UOC Reumatologia, Ospedale Civile di Pescara, Italy
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PO:30:155 | The role of nailfold videocapillaroscopy in the assessment of juvenile connective tissue diseases Marco Binda1, Beatrice Moccaldi1, Francesca Tirelli2, Anna Cuberli1, Andrea Benini1, Meneghel Alessandra2, Andrea Doria1, Francesco Zulian2, Elisabetta Zanatta1 | 1U.O.C. Reumatologia, Dipartimento di Medicina DIMED, Università degli Studi di Padova Padova, Italy; 2U.O.S.D. Reumatologia Pediatrica, Dipartimento per la Salute della Donna e del Bambino, Azienda Ospedaliera di Padova, Italy
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PO:32:178 | Effectiveness of oral anticoagulants in precapillary pulmonary hypertension associated with systemic sclerosis: a EUSTAR cohort study Nicola Farina1, Silvia Bellando-Randone1, Hilde Jenssen-Bjørkekjær2, David Launay3, Patricia Carreira4, Paolo Airò5, Serena Guiducci1, Dilia Giuggioli6, Gabriela Riemekasten7, Carmen-Pilar Simeón Aznar8, Christina Bergmann9, Elise Siegart10, Ivan Castellví11, Lesley Ann Saketkoo12, Jeska De Vries-Bouwstra13, Philipp Klemm14, Ulf Müller-Ladner14, Alexandra Balbir-Gurman15, Vanessa Smith16, Florenzo Iannone17, Luca Idolazzi18, Christopher Denton19, Edoardo Rosato20, Britta Maurer1, Yannick Allanore1, Yoshiya Tanaka1, Elisabetta Zanatta1, Oliver Distler1, Marco Matucci-Cerinic1, Cosimo Bruni1 | 1Department of Experimental and Clinical Medicine, Scleroderma Unit, Division of Rheumatology, University of Florence, Az Firenze, Italy; 2Department of Rheumatology, Hospital of Southern Norway Kristiansand, Norway; 3National Reference Center for Pulmonary Arterial Hypertension Pulmotension Lille, France; 4Hospital Universitario 12 de Octubre, Rheumatology Department Madrid Spain; 5ASST Spedali Civili of Brescia, University of Brescia, Rheumatology and Clinical Immunology Unit Brescia, Italy; 6Scleroderma Unit, Rheumatology Unit, University Hospital of Modena and Reggio Emilia Modena, Italy; 7Universitätsklinikum Schleswig-Holstein, Klinik für Rheumatologie und klinische Immunologie Lübeck Germany; 8Hospital Universitario Vall d'Hebron, Department of Internal Medicine, Systemic Autoimmune Diseases Unit Barcelona Spain; 9University Hospital Erlangen, Department Internal Medicine 3 Erlangen Germany; 10Charité University Hospital, Department of Rheumatology Berlin Germany; 11Hospital de la Santa Creu i Sant Pau Baercelona Spain; 12New Orleans Scleroderma and Sarcoidosis Patient Care and Research Center New Orleans, USA; 13Leiden University Medical Center, Department of Rheumatology Leiden, The Netherlands; 14JLU Giessen, Campus Kerckhoff, Department of Rheumatology and Clinical Immunology Center Bad Nauheim Germany; 15Rambam Health Care Campus, Rheumatology Institute Haifa, Israel; 16University of Ghent, Department of Rheumatology Ghent, Belgium; 17Rheumatology DiMePReJ, University of Bari, School of Medicine Bari, Italy; 18University of Verona, Section of Rheumatology, Department of Medicine Verona, Italy; 19Royal Free London and University College London Medical School, Centre for Rheumatology London, United Kingdom; 20Sapienza University of Rome, Department of Translational and Precision Medicine Azienda Ospedaliero-Universitaria Policl Roma, Italy
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PO:31:161 | First-line diagnostic tests to intercept primary heart involvement in systemic sclerosis: clinical associations from the SPRING-SIR registry Antonio Tonutti1|2, Francesca Motta1|2, Rossella De Angelis3, Valeria Riccieri4, Silvia Laura Bosello5, Fabio Cacciapaglia6, Veronica Codullo7, Giacomo De Luca8, Francesca Ingegnoli9, Dilia Giuggioli10, Clodoveo Ferri10, Marco Matucci-Cerinic8, Carlo Selmi1|2, Maria De Santis1|2 | 1Department of Biomedical Sciences, Humanitas University Pieve Emanuele, Milan, Italy; 2Rheumatology and Clinical Immunology, IRCCS Humanitas Research Hospital Rozzano, Milan, Italy; 3Università Politecnica delle Marche Ancona, Italy; 4Università degli Studi di Roma La Sapienza Roma, Italy; 5Università Cattolica del Sacro Cuore Roma, Italy; 6Università degli Studi di Bari Aldo Moro Bari, Italy; 7Reumatologia, Fondazione IRCCS Policlinico San Matteo Pavia, Italy; 8Università Vita-Salute San Raffaele Milano, Italy; 9Università degli Studi di Milano, Italy; 10Università degli Studi di Modena e Reggio Emilia, Italy
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PO:24:065 | Nailfold capillaroscopic in primary Sjögren's syndrome, clinical and serological correlations; a preliminary report from a reference center Caterina Vacchi1, Filippo Santoro1, Maria Grazia Malandra1, Giulia Cassone1, Alessandra Carobbio2, Martina Orlandi1, Dilia Giuggioli1 | 1Reumatologia Modena, Italy; 2Statistica Medica Modena, Italy
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PO:32:176 | Outcomes of upfront combination vs monotherapy with rituximab or mycophenolate mofetil for systemic sclerosis interstitial lung disease: results from a European Scleroderma Trials and Research cohort study Devis Benfaremo1, Corrado Campochiaro2, Gábor Kumánovics3, Christina Bergmann4, Elisabetta Zanatta5, David Launay6, Serena Guiducci7, Mickael Martin8, Carolina De Souza Müller9, Carlomaurizio Montecucco10, Luc Mouthon11, Gabriella Szucs12, Kastriot Kastrati13, Marie-Elise Truchetet14, Madelon Vonk15, Francesco Del Galdo16, Marco Matucci-Cerinic2, Gianluca Moroncini1, Yannick Allanore17. | 1Department of Clinical and Molecular Sciences, Marche Polytechnic University, Marche University Hospital, Ancona, Italy; 2Vita-Salute San Raffaele University, San Raffaele Hospital, Milano, Italy; 3University of Pécs, Department Of Rheumatology And Immunology, Pécs, Hungary; 4University Hospital Erlangen, Department Internal Medicine 3, Erlangen, Germany; 5Padova University Hospital, Rheumatology Unit, Padova, Italy; 6Univ. Lille, Inserm, CHU Lille, Department of Internal Medicine and Clinical Immunology, Lille, France; 7University of Florence, Azienda Ospedaliera Universitaria Careggi, Firenze, Italy; 8Poitiers University Hospital, Department of Internal Medicine Poitiers France; 9Hospital de Clinicas da Universidade Federal do Parana Curitiba Brazil; 10Università di Pavia e IRCCS Fondazione Policlinico S. Matteo, Pavia, Italy; 11Hôpital Cochin, Department of Internal Medicine, Paris, France; 12University of Debrecen, Faculty of Medicine, Department of Rheumatology, Debrecen, Hungary; 13Medical University of Vienna, Department of Medicine III, Division of Rheumatology, Vienna, Austria; 14CHU de Bordeaux, Rheumatology department, Bordeaux, France; 15Radboudumc, Department of Rheumatology Nijmegen The Netherlands; 16Leeds Raynauds and Scleroderma Program, NIHR Biomedical Research Centre, Leeds, United Kingdom; 17Université Paris Cité, Cochin Hospital, Rheumatology Department, Paris, France.
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PO:31:165 | Prevalence and incidence of skin telangectasia and their association with clinical features: analysis of the European Scleroderma Trials and Research cohort Gemma Lepri1, Lorenzo Tofani2, Silvia Bellando Randone1, Veronica Batani3, Paolo Airò4, Patricia Carreira5, Joerg Henes6, Alexandra Balbir Gurman7, Florenzo Iannone8, Antonella Marcoccia9, Luc Mouthon10, Branimir Anic11, Carolina De Souza Müller12, Armine Haroyan13, Ana Cristina Cordeiro14, Serena Guiducci And Eustar Coll1. | 1University of Florence, Dept of Experimental and Clinical Medicine, AOU Careggi, Division of Rheumatology Florence Italy; 2University of Florence, Dept of Statistics, Informatics, Applications, Florence, Italy; 3Unit of Immunology, Rheumatology, Allergy and Rare Diseases UnIRAR, IRCCS San Raffaele, Milano, Italy; 4Scleroderma Unit, UOC Rheumatology and Clinical Immunology, ASST Spedali Civili, Brescia, Italy; 5Dept of Rheumatology, 12 de Octubre University Hospital, Madrid, Spain; 6Centre for Interdisciplinary Rheumatology, Immunology and autoimmune diseases INDIRA, University Hospital Tuebingen, Tuebingen, Germany; 7Rheumatology Institute, Rambam Health Care Campus Haifa Israel; 8Dept of Precision and Regenerative Medicine and Ionian Area, University of Bari, Bari, Italy; 9Interdisciplinary Reference Center for Systemic Sclerosis CRIIS Sandro Pertini Hospital, Rome, Italy; 10Dept of Internal Medicine, Cochin Hospital, Paris Cité University, Paris, France; 11Div Clinical Immunology and Rheumatology, Dept Internal Medicine, School of Medicine, University Hospital Center Zagreb, Zagreb, Croatia; 12Rheumatology Division, Hospital de Clínicas da Universidade Federal do Parana, Curitiba, Brazil; 13Dept of Rheumatology, Yerevan State Medical University of Armenia, Yerevan, Armenia; 14Servico Reumatologia Hospital Garcia de Orta Almada, Almada, Portugal.
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PO:34:205 | Optical coherence tomography angiography: a window on systemic sclerosis microangiopathy Martina Orlandi1, Tommaso Verdina2, Filippo Santoro1, Alessandra Carobbio3, Amelia Spinella1, Marco De Pinto1, Giorgia Roveta1, Dilia Giuggioli1 | 1Internal Medicine Residency Program, Marche Polytechnic University, Ancona; 2Department of Clinical and Molecular Sciences, Marche Polytechnic University, Ancona; 3Department of Interna, Ancona, Italy
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PO:30:151 | Clinical characteristics and evolution of juvenile undifferentiated connective tissue diseases: results of a single-center study Nicoletta D'Angelo1|2, Stefania Costi3, Achille Marino3, Francesco Baldo3, Cecilia Beatrice Chighizola1|3, Roberto Felice Caporali1|2|3. | 1Università degli Studi di Milano, Dipartimento di Scienze Cliniche e di Comunità, Milano, Italy; 2ASST G. Pini-CTO, UOC di Clinica Reumatologica, Milano, Italy; 3ASST G. Pini-CTO, UOC di Clinica Reumatologica Pediatrica, Milano, Italy
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S13:5 | Association between vasoactive-vasodilating therapy and reduced detection of pulmonary arterial hypertension in systemic sclerosis: evidence from a European Scleroderma Trials and Research study Nicola Farina1, Silvia Bellando-Randone1, Sebastien Sanges2, Hilde Jenssen Bjørkekjær3, Lorenzo Tofani4, Marie-Elise Truchetet5, Vanessa Smith6, Andra Balanescu7, Christina Bergmann8, Yannick Allanore9, Philipp Klemm10, Simona Truglia11, Luca Idolazzi12, Christopher Denton13, Roberta Foti14, Anna Wojteczek15, Emmanuel Chatelus16, Madelon Vonk17, Serena Guiducci1, David Launay2, Eric Hachulla2, Jeska De Vries-Bouwstra18, Anna-Maria Hoffmann-Vold19, Oliver Distler20, Marco Matucci-Cerinic1, Cosimo Bruni1. | 1Department of Experimental and Clinical Medicine, Scleroderma Unit, Division of Rheumatology, University of Florence, Az, Firenze, Italy; 2Univ. Lille, Inserm, CHU Lille, Department of Internal Medicine and Clinical Immunology, Reference Center for Rare Autoi, Lille, France; 3Department of Rheumatology, Hospital of Southern Norway, Kristiansand, Norway; 4Department of Statistics, Informatics and Applications, University of Florence, Firenze, Italy; 5Rheumatology department, CHU de Bordeaux, Bordeaux, France; 6University of Ghent, Department of Rheumatology, Gent, Belgium; 7Department of Rheumatology, St. Maria Hospital, Carol Davila, University of Medicine and Pharmacy Bucharest Romania; 8Department Internal Medicine 3, University Hospital Erlangen, Erlangen, Germany; 9Rheumatology Department, Université Paris Cité, Cochin Hospital, Paris, France; 10Department of Rheumatology and Clinical Immunology Center, JLU Giessen, Campus Kerckhoff Bad Nauheim Germany; 11Reumatologia, Azienda Ospedaliero-Universitaria Policlinico Umberto I, Roma, Italy; 12Section of Rheumatology, Department of Medicine, University of Verona, Verona, Italy; 13Centre for Rheumatology, Royal Free London and University College London Medical School, London, United Kingdom; 14Division of Rheumatology, A.O.U. Policlinico-San Marco, Catania, Italy; 15Department of Rheumatology, Clinical Immunology, Geriatrics and Internal Medicine, Medical University of Gdansk, Univers Gdansk Poland; 16Department of Rheumatology, University Hospital Strasbourg Strasbourg France; 17Department of rheumatology, Radboud University Nijmegen Medical Center Nijmegen The Netherlands; 18Department of Rheumatology, Leiden University Medical Center Leiden The Netherlands; 19Department of Rheumatology, Oslo University Hospital, Oslo, Norway; 20Department of Rheumatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
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CO:06:2 | Deep immunophenotyping in patients with juvenile localized scleroderma reveals two distinct immunological endophenotypes Emiliano Marasco1, Angela Aquilani1, Rebecca Nicolai1, Ivan Caiello1, Fabrizio De Benedetti1. | 1Unità di Reumatologia, Ospdeale Pediatrico Bambino Gesù, Roma, Italy
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CO:07:1 | Assessing bone fragility in systemic sclerosis: results of the Sclerobone multicentric study Giammarco De Mattia1, Cristina Di Nicola2, Davide Rozza2, Manuel Sette3, Veronica Gerli3, Ludovica Pisapia1, Chiara Sgorbini1, Giulia Botticella4, Pamela Bernardini5, Francesca Bottazzi6, Francesca Lalli8, Luca Idolazzi7, Laura Bogliolo6, Monica Cesarotti8, Alessandra Rossi1, Alessandra Della Rossa1, Andrea Giusti4, Serena Guiducci5, Carlo Alberto Scirè2, Addolorata Corrado9, Nicoletta Del Papa3, Marta Mosca1, Chiara Crotti3, Maurizio Rossini7, Maurizio Mazzantini1. | 1UO Reumatologia, Dipartimento di Specialità Mediche e Chirurgiche, Azienda Ospedaliero-Universitaria Pisana, Pisa; 2Centro Studi SIR, Società Italiana di Reumatologia, Milano; 3UO Reumatologia, ASST Gaetano Pini-CTO, Milano; 4SC Reumatologia, Ospedale La Colletta, Azienda Sanitaria Locale 3 Liguria, Arenzano (GE); 5SOD Reumatologia, Azienda Ospedaliero-Universitaria Careggi, Firenze; 6SC Reumatologia, Fondazione IRCCS Policlinico San Matteo, Pavia; 7UOC Reumatologia, Azienda Ospedaliera Universitaria Integrata di Verona; 8SSD Reumatologia, Azienda Sanitaria Locale Perugia; 9Clinica Reumatologica Universitaria, Azienda Ospedaliero Universitaria di Foggia, Italy
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PO:25:081 | Atypical onset of anti-SAE-1 positive dermatomyositis: paraneoplastic flame hemorrhages in urothelial carcinoma Valentina Morandi1, Alessandro Biglia2, Francesco Maggiore1, Sofia Chiricolo1, Silvia Sammorì1, Maria Cristina Sacchi3|4, Edoardo Cammarata5, Maria Rosa Pellico6, Luigi Mario Castello2|3|7. | 1Dipartimento di Medicina Interna, SSD Reumatologia, AOUAL Santi Antonio e Biagio e Cesare Arrigo, Alessandria, Italy; 2 Dipartimento di Medicina Interna, AOUAL Santi Antonio e Biagio e Cesare Arrigo, Alessandria, Italy; 3Dipartimento di laboratorio di tecnologia, ricerca e innovazione DAIRI, AOUAL Santi Antonio e Biagio e Cesare Arrigo, Alessandria, Italy; 4AOUAL Santi Antonio e Biagio e Cesare Arrigo, Laboratorio Analisi, Alessandria, Italy; 5AOUAL Santi Antonio e Biagio e Cesare Arrigo, Dipartimento di Medicina Interna, SSD Dermatologia, Alessandria, Italy; 6ASST Gaetano Pini, divisione di Reumatologia Clinica, Milano, Italy; 7Università del Piemonte orientale, dipartimento di Medicina Traslazione, Novara, Italy.
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CO:03:1 | Distinct breath metabolomic signature in systemic sclerosis patients with pulmonary arterial hypertension Martina Iacubino1, Lorenzo Rocco1, Marco Vicenzi2|3, Chiara Bellocchi2|4, Marta Mozzo4, Adriana Severino3, Monica Caronni3, Alessandro Santaniello3, Gaia Montanelli3, Barbara Vigone3, Liam Grimmett5, Matthew Kerr5, Lorenzo Beretta3. | 1Scuola di specializzazione in Allergologia e Immunologia clinica, Università degli Studi di Milano; 2Dipartimento di Scienze Cliniche e Salute di Comunità, Dipartimento di Eccellenza 2023-2027, Università degli Studi di Milano; 3Dipartimento di Malattie Cardio-Toraciche-Vascolari, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano; 4Dipartimento di Immunologia Clinica e Medicina Interna, Scleroderma Unit - Fondazione IRCCS Ca' Granda Ospedale Maggiore, Milano, Italy; 5Owlstone Medical, Cambridge, UK
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PO:31:172 | Age and timing of onset of Raynaud's phenomenon and first non-Raynaud sign/symptom as prognostic factors in systemic sclerosis: a retrospective analysis from the systemic sclerosis progression investigation registry of the Italian Society for Rheumatology Silvia Peretti1, Cosimo Bruni2, Silvia Laura Bosello3, Fabio Cacciapaglia4-5, Corrado Campochiaro6-7, Veronica Codullo8, Lorenzo Dagna6-7, Rossella De Angelis9, Giacomo De Luca6-7, Dilia Giuggioli10, Serena Guiducci1, Florenzo Iannone4, Francesca Ingegnoli11, Valeria Riccieri12, Marco Matucci Cerinic6-7, Clodoveo Ferri10-13, Silvia Bellando Randone1. | 1Division of Rheumatology, Scleroderma Unit, Department of Experimental and Clinical Medicine, University of Florence, AO, Firenze, Italy; 2Division of Rheumatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland; 3Rheumatology Division, Catholic University of the Sacred Heart, Fondazione Policlinico Universitario A. Gemelli- IRCCS, Roma, Italy; 4Rheumatology Unit, Department of Precision and Regenerative Medicine-Ionian Area, University of Bari Aldo Moro, Bari, Italy; 5Reumatology Service, Internal Medicine Unit F.Miulli General Hospital, Acquaviva delle Fonti -Department of Medicine a, Bari, Italy; 6Unit of Immunology, Rheumatology, Allergy and Rare Diseases UnIRAR, Inflammation, Fibrosis and Ageing initiative INFL, Milano, Italy; 7Vita-Salute San Raffaele University, Milano, Italy; 8Department of Internal Medicine and Therapeutics, Università di Pavia, Italy; Division of Rheumatology, Fondazione IRCCS, Pavia, Italy; 9Rheumatology Unit, Department of Clinical and Molecular Sciences, Polytechnic University of Marche, Ancona, Italy; 10Rheumatology Unit, School of Medicine, University of Modena and Reggio Emilia, Modena, Italy; 11Division of Clinical Rheumatology, ASST Pini, Dept. of Clinical Sciences and Community Health, Research Center for Adul, Milano, Italy; 12Department of Rheumatology, Sapienza University of Rome, Roma, Italy; 13Rheumatology Clinic Madonna dello Scoglio Crotonei, Crotone, Italy.
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PO:32:182 | Disease characteristics of anti-centromere positive systemic sclerosis patients and risk factors for organ involvement: data from the EUSTAR cohort Corrado Campochiaro1, Jelena Colic2, Del Papa Nicoletta3, Oliver Distler4, Serena Guiducci5, Florenzo Iannone6, David Launay7, Yair Levy8, Britta Maurer9, Arsene Mekinian10, Predrag Ostojic2, Gabriela Riemekasten11, Petros Sfikakis12, Bojana Stamenkov13, Ulrich Walker14, Marie Elise Truchetet15, Madelon Vonk16, Francesco Del Galdo17, Giacomo De Luca1, Lorenzo Dagna1, Marco Matucci Cerinic1, Yannick Allanore18 | 1IRCCS San Raffaele Hospital; Vita Salute San Raffaele University Milan, Italy; 2University of Belgrade Belgrade, Serbia; 3UOC Reumatologia Clinica, ASST G. Pini CTO Milan, Italy; 4University Hospital Zurich Zurich, Switzerland; 5Department of Rheumatology, University of Florence Florence, Italy; 6Rheumatology Unit Bari, Italy; 7CHU Lille Lille, France; 8Department of Medicine Kfar Saba, Israel; 9Department for BioMedical Research, University of Bern Bern, Switzerland; 10Service de medecine interne Paris, France; 11Department of Rheumatology University of Lubeck Lubeck Germany; 12National and Kapodistrian University of Athens Athens, Greece; 13University School of Medicine, Nis Nis, Serbia; 14University Hospital Basel, Basel Basel, Switzerland; 15Bordeaux Hospital and University Bordeaux, France; 16Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands; 17Leeds Institute of Rheumatic and Muskuloskeletal Medicine Leeds, United Kingdom; 18Cochin Hospital Paris, France
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PO:33:191 | Evaluation of the living with pulmonary fibrosis questionnaire in patients with systemic sclerosis associated interstitial lung disease: monocentric results Claudia Barison1, Elda Piovani1, Eleonora Pedretti1, Eleonora Pazzi1, Liala Moschetti1, Ilaria Cavazzana1, Franco Franceschini1, Maria Grazia Lazzaroni1, Paolo Airò1. | 1Rheumatology and Clinical Immunology, Scleroderma Unit, ASST Spedali Civili of Brescia, University of Brescia, Brescia, Italy.
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PO:11:171 | Subcutaneous tocilizumab use in a young-onset mixed connective tissue disease patient with multiple treatment failures Rhaysa Araujo Mousinho1, Elide Lupi2, Massimiliano Limonta2 | 1Clinica di Reumatologia, Dipartimento di Medicina and 2Istituto di Anatomia Patologica, Dipartimento di Medicina di Laboratorio, Osp. S. M. della Misericordia, Università di Udine, Italy
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