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PO:33:193 | Self-reported oropharyngeal dysphagia and swallowing-related quality of life in people with systemic sclerosis: preliminary results of a cross-sectional study Nikla Pacenti1, Devis Benfaremo2, Federica Lucia Galli2, Andrea Colangelo3, Gianluca Moroncini2 | 1Internal Medicine Residency Program, Marche Polytechnic University Ancona, Italy; 2Department of Clinical and Molecular Sciences, Marche Polytechnic University Ancona, Italy; 3Medical student, Marche Polytechnic University Ancona, Italy
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PO:34:204 | Impact of anti-centromere antibodies on immunosuppressive therapy persistence in systemic sclerosis: a single-center case-control study Martina Salerno1, Marius Cadar1, Ilaria Bisconti1, Francesca Romana Di Ciommo1, Elena Platania1, Jacopo Landro1, Beatrice De Girolamo1, Davide Mohammad Reza Beigi1|2, Simona Truglia1, Fabrizio Conti1, Valeria Riccieri1 | 1Rheumatology unit, AOU and Università di Cagliari; 2Asl Biella, Ospedale degli Infermi, Ponderano (BI), Italy
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PO:19:283 | Hospitalization profile and complications in patients with adult-onset Still’s disease: results from a retrospective study of 74 cases Chiara Calabrese1, Alessandro Tomelleri1|2, Corrado Campochiaro1|2, Nicola Farina2, Elena Baldissera2, Marco Matucci-Cerinic1|2, Lorenzo Dagna1|2 | 1Libera Università Vita-Salute San Raffaele, Milano; 2Unità di Immunologia, Allergologia e malattie rare, IRCCS San Raffaele, Milano, Italy
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PO:34:205 | Optical coherence tomography angiography: a window on systemic sclerosis microangiopathy Martina Orlandi1, Tommaso Verdina2, Filippo Santoro1, Alessandra Carobbio3, Amelia Spinella1, Marco De Pinto1, Giorgia Roveta1, Dilia Giuggioli1 | 1Internal Medicine Residency Program, Marche Polytechnic University, Ancona; 2Department of Clinical and Molecular Sciences, Marche Polytechnic University, Ancona; 3Department of Interna, Ancona, Italy
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PO:12:180 | Echocardiographic screening of pulmonary hypertension in a multidisciplinary cohort of patients with interstitial lung disease Lorenzo Mattia Bianchessi1, Veronica Piccin1, Federica Sabatelli1, Lorenzo Cavagna1, Giovanni Zanframundo1, Domenicafederica Briganti2, Mauro Acquaro3, Stefano Ghio3, Domenico Sorace1, Valentina Vertui2, Ilaria Giana2, Andrea Patanè3, Veronica Codullo1 | 1UOC Reumatologia, Fondazione IRCCS Policlinico S. Matteo, Pavia; 2Centro Trapianti, Fondazione IRCCS Policlinico San Matteo, Pavia; 3UOC Cardiologia, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
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PO:37:260 | Mepolizumab in the treatment of patients with eosinophilic granulomatosis with polyangiitis: real-life experience from a single-center cohort Eleonora Bruschi1, Fabrizio Angeli1, Alessandro Belotti Masserini1, Stefania Bertocchi1, Silvia Breda1, Elide Lupi1, Valeria Rossi1, Tania Ubiali1, Massimiliano Limonta1 | 1ASST Papa Giovanni XXIII Bergamo Italy
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PO:36:252 | Long-Term Outcomes of Patients with Takayasu Arteritis in the Era of Biological Agents: a Multicenter International Study Alessandro Tomelleri1, Durga Prasanna Misra2, Fatma Alibaz-Oner3, Chiara Marvisi4, Chiara Calabrese1, Upendra Rathore2, Aysegul Avcu3, Adele Del Giudice4, Elisabetta Olivi4, Caterina Ricordi4, Corrado Campochiaro1, Elena Baldissera1, Marco Matucci-Cerinic1, Haner Direskeneli3, Carlo Salvarani4, Lorenzo Dagna1 | 1IRCCS Ospedale San Raffaele, Unità di Immunologia, Reumatologia, Allergologia e Malattie Rare Milano, Italy; 2Sanjay Gandhi Postgraduate Institute of Medical Sciences SGPGIMS, Clinical Immunology and Rheumatology Lucknow Country, India; 3Marmara University, School of Medicine, Department of Internal Medicine, Division of Rheumatology Istanbul, Turkey; 4Azienda USL-IRCCS di Reggio Emilia, Unità di Reumatologia Reggio Emilia, Italy
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PO:18:264 | Anifrolumab in Systemic Lupus Erythematosus: Bridging Clinical Trial Data with Real-World Evidence Giulia Cassone2, Filippo Santoro1, Caterina Vacchi2, Dilia Giuggioli2, Chiara Cabassi1 | 1UOC Reumatologia, AOU Policlinico di Modena, Università degli studi di Modena e Reggio Emilia Modena e Reggio Emilia, Italy; 2UOC Reumatologia, AOU Policlinico di Modena Modena, Italy
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PO:17:253 | Unveiling the gap: a multicenter study on factors driving patient-physician discrepancies in assessing disease activity in systemic lupus erythematosus Giorgia Ingrid Gozzoli1, Micaela Fredi1, Federica Bonaso1, Silvia Ebe Lucia Della Pina1, Claudia Barison1, Irene Lorenzini4, Raffaele Pericotti4, Anna Mattiuzzo4, Marcelo Neto2, Sofia Azevedo3, Cláudia Oliveira3, Cesare Tomasi4, Luís Sousa Inês2, Franco Franceschini1. | 1Rheumatology and Clinical Immunology Unit, ASST Spedali Civili of Brescia, Brescia, Italy; 2Rheumatology Department, Centro Hospitalar Universitário de Coimbra - ULS Coimbra, Coimbra, Portugal; 3Rheumatology Department, ULS Aveiro, Aveiro, Portugal; 4Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
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PO:24:063 | Interstitial lung disease in idiopathic inflammatory myopathy patients: efficacy and safety of nintedanib Giulia Buonsante1|2|3, Giacomo De Luca1|2|3, Veronica Batani1|2, Lorenzo Dagna1|2|3, Marco Matucci-Cerinic1|2|3, Corrado Campochiaro1|2|3 | 1Unit of Immunology, Rheumatology, Allergy and Rare Diseases UNIRAR, IRCCS San Raffaele Hospital Milano, Italy; 2Inflammation, Fibrosis and aging Initiative INFLAGE, IRCCS San Raffaele Hospital Milano, Italy; 3Vita-Salute San Raffaele University, Milano, Italy
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CO:08:5 | Clinical impact of anti-Ro52 antibodies in idiopathic inflammatory myopathies: insights from a multicenter Italian cohort Paola Bizioli1, Cesare Tomasi2, Francesca Bellisai3, Francesca Buzzulini4, Antonio Tonutti5|6, Angela Ceribelli5|6, Edoardo Conticini3, Anna Ghirardello7, Luca Iaccarino7, Danilo Villalta4, Franco Franceschini1, Ilaria Cavazzana1. | 1Rheumatology and Clinical Immunology Unit - ERN ReCONNET, ASST Spedali Civili of Brescia; 2Department of Clinical and Experimental Sciences, University of Brescia; 3Department of Medicine, Surgery and Neurosciences, Rheumatology Unit, University of Siena; 4Department of Laboratory Immunology and Allergology, Santa Maria degli Angeli Hospital, Pordenone; 5Department of Biomedical Sciences, Humanitas University, Rozzano (MI); 6Rheumatology and Clinical Immunology, Istituti di Ricovero e Cura a Carattere Scientifico, Humanitas Research Hospital, Rozzano (MI); 7Division of Rheumatology, Department of Medical and Surgical Sciences, University of Padova, Italy
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CO:06:3 | Clinical and laboratory markers for distinguishing VEXAS from Schnitzler's syndrome in male patients with skin involvement: insights from the International AIDA Network Registries Valeria Caggiano1, Jessica Sbalchiero1, Micol Frassi2, Andrea Hinojosa-Azaola3, Francesca Crisafulli2, Franco Franceschini2, Paolo Sfriso4, Sara Bindoli4, José Hernández-Rodríguez5, Henrique A. Mayrink Giardini6, Giuseppe Lopalco7, Florenzo Iannone7, Ombretta Viapiana8, Amato De Paulis9, Lorenzo Dagna10, Antonio Gidaro11, Serena Bugatti12, Matteo Piga13, Fabrizio Conti14, Rosetta Vitetta15, Cecilia Chighizola16, Marcello Govoni17, Giacomo Emmi18, Paola Triggianese19, Carmelo Gurnari19, Bruno Frediani1, Claudia Fabiani1, Luca Cantarini1, Antonio Vitale1, for the AIDA Network1 | 1Department of Medical Sciences, Surgery and Neurosciences, University of Siena; 2University of Brescia, Italy; 3Department of Immunology and Rheumatology, Mexico City, Mexico; 4Rheumatology Unit, University of Padova, Italy; 5Clinical Unit of Autoinflammatory Diseases, Hospital Clínic of Barcelona, Spain; 6Rheumatology Division, Universidade de São Paulo, Brazil; 7University of Bari; 8Rheumatology Unit, University and Azienda Ospedaliera Universitaria Integrata of Verona; 9University of Napoli "Federico II"; 10Università Vita-Salute San Raffaele, Milano; 11Luigi Sacco Hospital, University of Milano; 12Università di Pavia; 13University and AOU of Cagliari; 14AOU Policlinico Umberto I, Sapienza University of Rome; 15Unit of Rheumatology, ASL Sant' Andrea Hospital, Vercelli; 16University of Milano; 17Azienda Ospedaliero-Universitaria S. Anna, Ferrara; 18University of Trieste; 19University of Rome-Tor Vergata, Rome, Italy.
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PO:32:182 | Disease characteristics of anti-centromere positive systemic sclerosis patients and risk factors for organ involvement: data from the EUSTAR cohort Corrado Campochiaro1, Jelena Colic2, Del Papa Nicoletta3, Oliver Distler4, Serena Guiducci5, Florenzo Iannone6, David Launay7, Yair Levy8, Britta Maurer9, Arsene Mekinian10, Predrag Ostojic2, Gabriela Riemekasten11, Petros Sfikakis12, Bojana Stamenkov13, Ulrich Walker14, Marie Elise Truchetet15, Madelon Vonk16, Francesco Del Galdo17, Giacomo De Luca1, Lorenzo Dagna1, Marco Matucci Cerinic1, Yannick Allanore18 | 1IRCCS San Raffaele Hospital; Vita Salute San Raffaele University Milan, Italy; 2University of Belgrade Belgrade, Serbia; 3UOC Reumatologia Clinica, ASST G. Pini CTO Milan, Italy; 4University Hospital Zurich Zurich, Switzerland; 5Department of Rheumatology, University of Florence Florence, Italy; 6Rheumatology Unit Bari, Italy; 7CHU Lille Lille, France; 8Department of Medicine Kfar Saba, Israel; 9Department for BioMedical Research, University of Bern Bern, Switzerland; 10Service de medecine interne Paris, France; 11Department of Rheumatology University of Lubeck Lubeck Germany; 12National and Kapodistrian University of Athens Athens, Greece; 13University School of Medicine, Nis Nis, Serbia; 14University Hospital Basel, Basel Basel, Switzerland; 15Bordeaux Hospital and University Bordeaux, France; 16Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands; 17Leeds Institute of Rheumatic and Muskuloskeletal Medicine Leeds, United Kingdom; 18Cochin Hospital Paris, France
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PO:24:070 | Preliminary descriptive data from a single-centre cohort of patients with idiopathic inflammatory myopathy: focus on paraneoplastic and non-paraneoplastic patients Silvia Ebe Lucia Della Pina1, Paola Bizioli1, Samantha Mazza2, Caproli Alessia1, Cesare Tomasi1, Ilaria Cavazzana1, Franco Franceschini1. | 1S.C.O. Reumatologia ed Immunologia Clinica, ASST Spedali Civili di Brescia, Università degli Studi di Brescia, Brescia, Italy; 2Università degli Studi di Brescia, Brescia, Italy.
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PO:14:205 | Primary antiphospholipid antibody syndrome: association between new classification criteria manifestations and a higher-risk disease phenotype Sara Ferrigno1, Vittorio Forte2, Marco Panetta1, Sergio Lisena1, Giorgia Ranucci2, Luigi De Marco1, Elisabetta Greco1, Alberto Bergamini1, Maria Sole Chimenti1, Paola Conigliaro1. | 1Rheumatology, allergology and clinical immunology, Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy; 2Hematology, Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy.
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PO:36:245 | Uncovering clinical and demographic differences in major organ involvement versus benign Behçet’s disease: insights from a single-centre study Federica Di Cianni1, Antonello Sulis1, Maria Laura Manca2, Rosaria Talarico1, Marta Mosca1. | 1Rheumatology Unit, University of Pisa, Pisa, Italy; 2Department of Clinical and Experimental Medicine and Department of Mathematics, University of Pisa, Pisa, Italy.
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PO:04:056 | Willingness of patients with psoriatic arthritis to participate in pharmacological and nutritional clinical trials: a cross-sectional study Miriam Perino1|2, Francesca Ingegnoli1|2, Luca Ingrao1|2, Debora Piredu1|2, Antonio Varvaro1|2, Camilla Riboldi1|2, Gilberto Cincinelli2, Francesca Desiati2, Martina Biggioggero2, Orazio De Lucia2, Silvia Casari2, Maria Manara2, Ennio Giulio Favalli1|2, Roberto Caporali1|2 | 1Università degli Studi di Milano, Dipartimento di Scienze Cliniche e di Comunità, Milano; 2ASST G. Pini-CTO, UOC di Clinica Reumatologica, Milano, Italy
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CO:09:3 | Effectiveness and safety of nintedanib in autoimmune systemic diseases: real life data from an Italian multicentre study (Island group) of the Italian Society of Rheumatology Corrado Campochiaro1, Paola Conigliaro2, Gianluca Sambataro3, Marco Matucci-Cerinic1, Marco Sebastiani4, Gianluca Bajocchi5, Angelo Fassio6, Elena Treppo7, Elisabetta Zanatta8, Elena Bartolini9, Francesco Ferro10, Chiara Bazzini11, Nicoletta Del Papa12, Gemma Lepri13, Andrea Lo Monaco14, Marta Favero15, Annamaria Iuliano16, Francesca Li Gobbi17, Maria Sole Chimenti2, Giuseppe Muscato18, Giacomo De Luca1, Francesca Cozzini4, Lucia Dardani5, Francesco Pollastri6, Alessandro Gattron7, Beatrice Moccaldi8, Caterina Antonini9, Gaetano La Rocca10, Ilaria Cavazzana11, Andreina Manfredi5|19. | 1IRCCS San Raffaele Hospital, Vita-Salute San Raffaele, Milano; 2U.O.C. Reumatologia Dipartimento di Medicina dei Sistemi Università di Roma-Tor Vergata, Roma; 3Università Kore, Enna; 4University of Parma, Azienda Ospedaliera di Piacenza; 5UOC Reumatologia, AUSL IRCCS Reggio Emilia; 6UOC Reumatologia Università degli Studi di Verona; 7Dipartimento di Medicina, Clinica di Reumatologia, Università degli Studi di Udine; 8UOC Reumatologia, Dipartimento di Medicina DIMED, Azienda Ospedale Università di Padova; 9SC Interaziendale di Reumatologia, Dipartimento di Medicina e Chirurgia, Università di Perugia, Azienda Integrata Università; 10Dipartimento di Medicina Clinica e Sperimentale UO Reumatologia-Universitaria AOU Pisa; 11U.O. Reumatologia e Immunologia Clinica ASST Spedali Civili di Brescia; 12Clinica Reumatologica, Milano; 13S.O.D. di Reumatologia AOU Careggi, Firenze; 14UOC Reumatologia Azienda Ospedaliero-Universitaria Sant'Anna, Ferrara; 15Internal Medicine I, Department of Medicine, Ca' Foncello Hospital, AULSS2 Marca Trevigiana, Treviso; 16UOC Reumatologia, AO San Camillo Forlanini, Roma; 17Rheumatology Unit, S.Giovanni di Dio Hospital, Firenze; 18Department of Clinical and Experimental Medicine, Regional Referral Center for Rare Lung Disease, Policlinico, Catania; 19Università degli Studi di Modena e Reggio Emilia, Italy
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CO:11:6 | Off-therapy remission in systemic lupus erythematosus: the BLys lupus flare index (BLyFI) as a decision tool for immunosuppressive therapy withdrawal in remitted patients Noemi Merra1, Anna Giorgia Osele1, Davide Ragno1, Greta Hulej1, Zahrà Rahmé1, Ilenia Anna Gennaio1, Filippo Vesentini1, Margherita Zen1, Luca Iaccarino1, Andrea Doria1 | Università degli Studi di Padova, Italy
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PO:16:225 | Belimumab in refractory and/or non-criteria manifestations of antiphospholipid syndrome: ad interim analysis on Quality-of-Life changes from the BLAST trial Alessio Conti1, Lois Ira Capulong1, Irene Cecchi1, Elena Rubini1, Chiara Bova1, Massimo Radin1, Alice Barinotti1, Beatrice Ala1, Silvia Grazietta Foddai1, Daniela Rossi1, Roberta Fenoglio1, Savino Sciascia1 | 1Centro di Eccellenza Universitario per le Malattie Nefrologiche, Reumatologiche e Rare, S.G.Bosco -ASL Città di Torino, Italy
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PO:32:180 | Clinical and hemodynamic profile of patients with SSC-PAH with and without pulmonary veno-occlusive disease: a single-center study Anna Cuberli1, Michele Strosio2, Alessandro Magi2, Beatrice Moccaldi1, Marco Binda1, Andrea Benini1, Andrea Doria1, Martina Perazzolo Marra2, Giulia Famoso2, Laura De Michieli2, Elisabetta Zanatta1|2 | 1UOC Reumatologia, DIDAS Medicina Dei SIstemi, Azienda Ospedale Università di Padova; 2UOC Cardiologia, DIDAS Medicina Dei Sistemi, Azienda Ospedale Università di Padova, Italy
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PO:30:151 | Clinical characteristics and evolution of juvenile undifferentiated connective tissue diseases: results of a single-center study Nicoletta D'Angelo1|2, Stefania Costi3, Achille Marino3, Francesco Baldo3, Cecilia Beatrice Chighizola1|3, Roberto Felice Caporali1|2|3. | 1Università degli Studi di Milano, Dipartimento di Scienze Cliniche e di Comunità, Milano, Italy; 2ASST G. Pini-CTO, UOC di Clinica Reumatologica, Milano, Italy; 3ASST G. Pini-CTO, UOC di Clinica Reumatologica Pediatrica, Milano, Italy
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PO:35:223 | Biologic therapy for sustained remission in eosinophilic myocarditis: real-world evidence from a tertiary center experience Federica Davanzo1, Caterina Menghi2, Andrea Silvio Giordani2, Anna Baritussio2, Federico Scognamiglio2, Cristina Vicenzetto2, Luca Iorio1, Renzo Marcolongo2, Cristina Basso3, Andrea Doria1, Roberto Padoan1, Alida Linda Patr Caforio2 | 1Rheumatology Unit, Department of Medicine, University of Padua Padova, Italy; 2Cardiology Unit, Department of Cardiac, Vascular, Thoracic Sciences and Public Health, University of Padua Padova, Italy; 3Cardiovascular Pathology, Department of Cardiac, Thoracic and Vascular Sciences and Public Health, University of Padua Padova, Italy
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PO:28:127 | Efficacy of b/ts-DMARDS therapy on depressive and anxiety symptoms in patients with chronic inflammatory joint diseases: preliminary results of a prospective study Nikita Pecani1, Christian D'Elia1, Francesca Bartoli1, Sabrina Aliberti1, Francesco Rotella2, Arianna Ida Altomare2, Francesco Vinci2, Lorenzo Cortoni2, Davide Benedetti3, Camilla Ferrari4, Gemma Lepri1, Silvia Bellando Randone1, Serena Guiducci1 | 1SOD Reumatologia, Dipartimento di Medicina Sperimentale e Clinica, Università degli Studi di Firenze; 2Unità di Psichiatria, Dipartimento di Scienze della Salute, Università degli Studi di Firenze; 3Dipartimento Salute Mentale, USL Umbria, Città di Castello (PG); 4Scuola di Scienze della Salute Umana - Università degli Studi di Firenze, Italy
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PO:23:052 | Muscular and myocardial involvement in antisynthetase syndrome: a retrospective real-life study Giulia Buonsante1|2|3, Giacomo De Luca1|2|3, Veronica Batani1|2, Daniele Scaramuzzi1|2|3, Lorenzo Dagna1|2|3, Marco Matucci-Cerinic1|2|3, Corrado Campochiaro1|2|3. | 1Unit of Immunology, Rheumatology, Allergy and Rare Diseases UNIRAR, IRCCS San Raffaele Hospital, Milano, Italy; 2Inflammation, Fibrosis and aging Initiative INFLAGE, IRCCS San Raffaele Hospital, Milano, Italy; 3Vita-Salute San Raffaele University, Milan, Italy, Milano, Italy.
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CO:08:6 | Prevalence, incidence and survival in interstitial lung disease secondary to primary Sjögren’s syndrome. Results from the “EMERGE” longitudinal study Alessandra Rai1, Caterina Vacchi2, Stefania Cerri3, Roberta Eufrasia Ledda4, Giulia Cassone2, Dario Andrisani3, Filippo Gozzi3, Lucia Dardani1, Fabiola Atzeni5, Athina Patsoura3, Francesca Cozzini1, Marco Sebastiani6, Andreina Manfredi1. | 1USL-IRCCS Reggio Emilia, University of Modena and Reggio Emilia; 2Azienda Ospedaliero Universitaria Policlinico di Modena; 3 Pulmonology Unit, AOU Policlinico di Modena, University of Modena and Reggio Emilia; 4Radiology Unit, Azienda Ospedaliera di Parma, University of Parma; 5 Policlinico Gaetano Martino, University of Messina; 6Azienda Ospedaliera di Piacenza,University of Parma, Italy
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CO:10:3 | Clinical response to JAK inhibitors or non-TNFi-targeted biologicals according to synovial tissue characteristics in patients with difficult-to-treat rheumatoid arthritis Mariangela Salvato1, Alessandro Giollo1, Francesca Frizzera1, Kiren Khalid1, Lorenzo Di Luozzo1, Maria Capita1, Marianna Tamussin1, Carlo Garaffoni2, Marny Fedrigo3, Annalisa Angelini3, Ettore Silvagni2, Andrea Doria1. | 1Rheumatology Unit, Department of Medicine - DIMED, University of Padova; 2Rheumatology Unit, Department of Medical Sciences, University of Ferrara and Azienda Ospedaliero-Universitaria S. Anna; 3Cardiovascular Pathology, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, Italy
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CO:02:4 | Whole blood hypercoagulable profiles in patients with rheumatoid arthritis Lorenzo Di Luozzo1, Alessandro Giollo1, Mariangela Salvato1, Francesca Frizzera1, Kiren Khalid1, Luca Spiezia2, Andrea Benetti2, Chiara Samà2, Paolo Simioni2, Andrea Doria1. | 1Unità di Reumatologia, Azienda Ospedaliera di Padova; 2Dipartimento di Medicina, Università di Padova, Italy
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PO:09:134 | The impact of intra-articular hyaluronic acid injections on osteoarthritis synovitis: a study on synovial tissue of total knee arthroplasty patients Orazio De Lucia1, Laura Giudice1|2, Carolina Artusi1, Luca Ingrao1|2, Giorgia Trignani1|2, Matteo Ferrito1, Andrea Amati1|2, Marta Arese1|2, Camilla Riboldi1|2, Isabella Scotti1, Antonella Murgo1, Ennio Giulio Favalli1|2, Antonina Parafioriti3, Elisabetta Armiraglio3, Andrea Di Bernardo3, Filippo Calanna4, Chiara Fossati4, Pietro Simone Randelli4|5, Roberto Felice Caporali1|2 | 1Dipartimento di Reumatologia e Scienze Mediche,ʁSST Centro Specialistico Ortopedico Traumatologico Gaetano Pini-CTO, Milano; 2Dipartimento di Scienze Cliniche e di Comunità, Università degli Studi di Milano; 3UOC Anatomia Patologica, ASST Centro Specialistico Ortopedico Traumatologico Gaetano Pini-CTO, Milano; 4UOC 1° Clinica Ortopedica, ASST Centro Specialistico Ortopedico Traumatologico Gaetano Pini-CTO, Milano; 5Università degli Studi di Milano, Dipartimento di Scienze Biomediche per la Salute, Milano, Italy
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