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Antibodies to extractable nuclear antigens (ENAS) in systemic lupus erythematosus patients: correlations with clinical manifestations and disease activity

Y. Emad, T. Gheita, H. Darweesh, P. Klooster, R. Gamal, H. Fathi, N. El-Shaarawy, M. Gamil, M. Hawass, R.M. El-Refai, H. Al-Hanafi, S. Abd-Ellatif, A. Ismail, J. Rasker

85-91

06-07-2018

https://doi.org/10.4081/reumatismo.2018.1027

2898

PDF: 1630
Drug survival and reasons for discontinuation of the first course of biological therapy in 301 juvenile idiopathic arthritis patients

M. Romano, I. Pontikaki, M. Gattinara, I. Ardoino, C. Donati, P. Boracchi, P.L. Meroni, V. Gerloni

278-285

17-03-2014

https://doi.org/10.4081/reumatismo.2013.682

2944

PDF: 1445
Joint involvement in patients affected by systemic lupus erythematosus: application of the swollen to tender joint count ratio

E. Cipriano, F. Ceccarelli, L. Massaro, F. R. Spinelli, C. Alessandri, C. Perricone, G. Valesini, F. Conti

62-67

16-09-2015

https://doi.org/10.4081/reumatismo.2015.828

2894

PDF: 1277
Regional differences of vitamin D deficiency in rheumatoid arthritis patients in Italy

M. Rossini, G. D'Avola, M. Muratore, N. Malavolta, F. Silveri, G. Bianchi, B. Frediani, G. Minisola, M. L. Sorgi, M. Varenna, R. Foti, G. Tartarelli, G. Orsolini, S. Adami

113-120

23-07-2013

https://doi.org/10.4081/reumatismo.2013.113

3569

PDF: 1412
Association between the response to B cell depletion therapy and the allele*2 of the HS1,2A enhancer in seropositive rheumatoid arthritis patients

S. Canestri, M.C. Totaro, E. Serone, B. Tolusso, D. Frezza, E. Gremese, G. Ferraccioli

368-373

20-12-2012

https://doi.org/10.4081/reumatismo.2012.368

2498

PDF: 890
Paget’s disease

I. Bertoldi, L. Cantarini, G. Filippou, B. Frediani

171-183

28-07-2014

https://doi.org/10.4081/reumatismo.2014.789

5835

PDF: 3171
RETRACTED - Pain in systemic sclerosis

S. Stisi, P. Sarzi-Puttini, M. Benucci, G. Biasi, S. Bellissimo, R. Talotta, F. Atzeni

44-47

06-06-2014

https://doi.org/10.4081/reumatismo.2014.764

2185

PDF: 1209
Assessment of subclinical atherosclerosis in ankylosing spondylitis: correlations with disease activity indices

F.M. Perrotta, A. Scarno, A. Carboni, V. Bernardo, M. Montepaone, E. Lubrano, A. Spadaro

105-112

23-07-2013

https://doi.org/10.4081/reumatismo.2013.105

3253

PDF: 1185
Evidence-based algorithm for diagnosis and assessment in psoriatic arthritis: results by Italian DElphi in psoriatic Arthritis (IDEA)

G. Lapadula, A. Marchesoni, F. Salaffi, R. Ramonda, C. Salvarani, L. Punzi, L. Costa, F. Caso, D. Simone, G. Baiocchi, C. Scioscia, M. Di Carlo, R. Scarpa, G. Ferraccioli

126-136

16-12-2016

https://doi.org/10.4081/reumatismo.2016.913

3351

PDF: 2240
Predictive factors for partial remission according to the Ankylosing Spondylitis Assessment Study working group in patients with ankylosing spondylitis treated with anti-TNFα drugs

F.M. Perrotta, O. Addimanda, R. Ramonda, S. D’Angelo, E. Lubrano, A. Marchesoni, I. Olivieri, L. Punzi, C. Salvarani, A. Spadaro

208-214

06-11-2014

https://doi.org/10.4081/reumatismo.2014.756

2912

PDF: 1604
Disease activity assessment in large vessel vasculitis

L. Magnani, A. Versari, D. Salvo, M. Casali, G. Germanò, R. Meliconi, L. Pulsatelli, D. Formisano, G. Bajocchi, N. Pipitone, L. Boiardi, C. Salvarani

86-90

https://doi.org/10.4081/reumatismo.2011.86

2088

PDF: 1157
Chronic widespread pain in spondyloarthritis

F. Atzeni, L. Boccassini, M. Di Franco, A. Alciati, A. Marsico, M. Cazzola, G. Cassisi, P. Sarzi-Puttini

28-32

06-06-2014

https://doi.org/10.4081/reumatismo.2014.761

3022

PDF: 1735
Low body mass index in long standing rheumatoid arthritis: relation to RA disease activity and functional indices

S.M. Gamal, A.K. Alkemary, M.A. Abdo, A.H.M. El Dakrony

72-77

06-07-2018

https://doi.org/10.4081/reumatismo.2018.999

1796

PDF: 825
Expansion of CD4+CD25-GITR+ regulatory T-cell subset in the peripheral blood of patients with primary Sjögren's syndrome: correlation with disease activity

A. Alunno, G. Nocentini, O. Bistoni, M.G. Petrillo, E. Bartoloni Bocci, S. Ronchetti, E. Lo Vaglio, C. Riccardi, R. Gerli

293-298

11-12-2012

https://doi.org/10.4081/reumatismo.2012.293

2830

PDF: 1110
Biomarkers and prognostic stratification in psoriatic arthritis

L. Bogliolo, G. Crepaldi, R. Caporali

88-98

05-06-2012

https://doi.org/10.4081/reumatismo.2012.88

1557

PDF: 1347
Disease activity assessment for juvenile idiopathic arthritis in transitional care

F. La Torre, C. Coppola, M.G. Anelli, F. Cacciapaglia, G. Lopalco, F. Cardinale, F. Iannone

24-06-2024

https://doi.org/10.4081/reumatismo.2024.1638

2016

PDF: 916
PO:13:189 | Greater impact of psoriatic arthritis in females: is this mediated primarily by disease activity? Roberta Masnata¹, Valentina Boni¹, Giusy Peluso¹, Giulia Calabrese¹, Enrico De Lorenzis¹, Gerlando Natalello¹, Maria Antonietta D'Agostino¹, Augusta Ortolan¹. | ¹UOC Reumatologia e Immunologia Clinica- Fondazione Policlinico Agostino Gemelli IRCCS-Università Cattolica Sacro Cuore, Roma, Italy.

Società Italiana di Reumatologia

25-11-2025

https://doi.org/10.4081/reumatismo.2025.2030

143
PO:03:044 | Impact of Inflammatory Bowel Disease on Clinical Phenotype and Treatment Response in Patients with Psoriatic Arthritis Maria Morrone¹, Maria Giannotta¹, Vincenzo Venerito¹, Greta Giulia Dipietrangelo¹, Stefano Stano¹, Florenzo Iannone¹, Giuseppe Lopalco¹ | ¹Department of Precision and Regenerative Medicine and Ionian Area DiMePRe-J University of Bari, Bari, Italy

Società Italiana di Reumatologia

18-03-2026

https://doi.org/10.4081/reumatismo.2025.2294

27
Sjögren’s syndrome and mean platelet volume

M. E. Tezcan, Ş. Demir, M. Sargın, M. Aliustaoğlu, B. Göker

33-34

30-06-2015

https://doi.org/10.4081/reumatismo.2015.752

1431

PDF: 1188
Biomarkers, imaging and disease activity indices in patients with early axial spondyloarthritis: the Italian arm of the SpondyloArthritis-Caught-Early (SPACE) Study

M. Lorenzin, A. Ortolan, S. Vio, M. Favero, F. Oliviero, M. Zaninotto, C. Cosma, C. Lacognata, L. Punzi, R. Ramonda

65-74

03-08-2017

https://doi.org/10.4081/reumatismo.2017.977

2050

PDF: 1418
Urinary CXCL10: a marker of nephritis in lupus patients

M. A. Marie, R. E. Abu Khalil, H. M. Habib

292-297

17-03-2014

https://doi.org/10.4081/reumatismo.2013.719

3272

PDF: 1794
Is CDAI comparable to DAS 28 and SDAI regarding inter-observer agreement and correlation to MHAQ in Egyptian RA patients?

K. El-Hadidi, S.M. Gamal, S. Saad, N.Y. Elsaid

203-208

28-01-2020

https://doi.org/10.4081/reumatismo.2019.1222

2154

PDF: 953
Spine and sacroiliac joints on magnetic resonance imaging in patients with early axial spondyloarthritis: prevalence of lesions and association with clinical and disease activity indices from the Italian group of the SPACE study

M. Lorenzin, A. Ortolan, P. Frallonardo, S. Vio, C. Lacognata, F. Oliviero, L. Punzi, R. Ramonda

72-82

09-09-2016

https://doi.org/10.4081/reumatismo.2016.885

3217

PDF: 1885
Measurement of serum interferon alpha in Egyptian patients with systemic lupus erythematosus and evaluation of its effect on disease activity: a case-control study

A. Fayed, M.M. El Menyawi, M. Ghanema, O. Shaker, R. Elgohary

145-153

19-11-2020

https://doi.org/10.4081/reumatismo.2020.1308

1273

PDF: 765
Therapeutic strategies in severe neuropsychiatric systemic lupus erythematosus: experience from a tertiary referral centre

A. Bortoluzzi, M. Padovan, I. Farina, E. Galuppi, F. De Leonardis, M. Govoni

350-359

20-12-2012

https://doi.org/10.4081/reumatismo.2012.350

3336

PDF: 2757
The use of rituximab in idiopathic inflammatory myopathies: description of a monocentric cohort and review of the literature

S. Barsotti, E. Cioffi, A. Tripoli, A. Tavoni, A. d’Ascanio, M. Mosca, R. Neri

78-84

06-07-2018

https://doi.org/10.4081/reumatismo.2018.1011

2858

PDF: 1472
Pain in rheumatoid arthritis: a critical review

P. Sarzi-Puttini, F. Salaffi, M. Di Franco, L. Bazzichi, G. Cassisi, R. Casale, M. Cazzola, S. Stisi, M. Battellino, F. Atzeni

18-27

06-06-2014

https://doi.org/10.4081/reumatismo.2014.760

6649

PDF: 3745
Possible interplay between interleukin-15 and interleukin-17 into the pathogenesis of idiopathic inflammatory myopathies

A. Notarnicola, G. Lapadula, D. Natuzzi, F. Iannone

215-223

06-11-2014

https://doi.org/10.4081/reumatismo.2014.746

2041

PDF: 1280
PO:07:111 | Worsening of patient-reported outcomes is an early predictor of disease flare in patients with rheumatoid arthritis in course of treatment with conventional synthetic disease modifying anti-rheumatic drugs Ludovico De Stefano^1|2, Federica Sabatelli^1|2, Clelia Zampaglione^1|2, Blerina Xoxi², Antonio Manzo^1|2, Carlomaurizio Montecucco^1|2, Serena Bugatti^1|2. | ¹Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy; ²Division of Rheumatology, IRCCS Policlinico San Matteo Foundation, Pavia, Italy.

Società Italiana di Reumatologia

25-11-2025

https://doi.org/10.4081/reumatismo.2025.2022

135
Anti-dsDNA negative and anti-Ro positive lupus nephritis: a report of a rare case

D. Jain, H.K. Aggarwal, V. Kaverappa, S. Dhayia, P. Jain, S. Yadav

302-306

17-03-2014

https://doi.org/10.4081/reumatismo.2013.706

5231

PDF: 1415
CO:01:4 | Identify predictors of relapse in idiopathic inflammatory myopathies: insights from an international cohort Cristina Bochicchio^1|2, Maria Rosa Pellico^1|2, Claudia Iannone^1|2, Lekshmi Minikumari Rahulan³, Marco Fornaro⁴, Ilaria Cavazzana⁵, Edoardo Conticini⁶, Musataka Musataka⁷, Akira Yoshida⁷, Silvia Cavalli^1|2, Silvia Grazzini⁶, Giulio Fraticelli⁸, Alessia Gatti⁵, Giulio Lopinto⁴, Paolo Semeraro⁵, Veronica Batani⁸, Thomas Patric Sheeran⁹, Florenzo Iannone⁴, Giacomo De Luca⁸, Roberto Caporali^1|2, Latika Gupta^9|10|11, Nicoletta Del Papa². | ¹Department of Clinical Sciences and Community Health, University of Milano; ²Department of Rheumatology and Medical Sciences, ASST Gaetano Pini-CTO Institute, Milano, Italy; ³Rheumatology "Sanjay Gandhi" Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India; ⁴Unit of Rheumatology, Department of Precision and Regenerative Medicine, Area Jonica, University of Bari; ⁵Rheumatology and Clinical Immunology Unit, ASST Spedali Civili di Brescia; ⁶Rheumatology Unit, Department of Medicine, Surgery and Neurosciences, University of Siena, Italy; ⁷Department of Allergy and Rheumatology Nippon Medical School Graduate School of Medicine, Tokyo, Japan; ⁸Unit of Immunology, Rheumatology, Allergy and Rare Diseases, IRCCS San Raffaele Hospital, Milano, Italy; ⁹Department of Rheumatology, Royal Wolverhampton Hospitals NHS Trust, Wolverhampton, UK; ¹⁰Francis Crick Institute, London, UK; ¹¹School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, UK

Società Italiana di Reumatologia

25-11-2025

https://doi.org/10.4081/reumatismo.2025.1964

186
PO:35:224 | Capturing What BVAS Misses: Patient-Reported Outcomes Reflect Disease Activity and Burden in EGPA Marta Codirenzi¹, Federica Davanzo¹, Luca Iorio¹, Eleonora Fiorin¹, Roberta Prevedello¹, Roberto Padoan¹, Andrea Doria¹ | ¹Unità di reumatologia, dipartimento di medicina DIMED,Università degli studi di Padova, Italy

Società Italiana di Reumatologia

18-03-2026

https://doi.org/10.4081/reumatismo.2025.2384

11
PASSing to the patient side: early achieving of an acceptable symptom state in patients with rheumatoid arthritis treated with Janus kinase inhibitors

Cristina Garufi, Silvia Mancuso, Fulvia Ceccarelli, Letizia Caruso, Cristiano Alessandri, Manuela Di Franco, Roberta Priori, Valeria Riccieri, Rossana Scrivo, Simona Truglia, Fabrizio Conti, Francesca Romana Spinelli

05-11-2024

https://doi.org/10.4081/reumatismo.2024.1725

2658

PDF: 394
PO:15:209 | Attainment of remission or lupus low disease activity state in single center Lupus Clinic Paola Tedoldi^1|2, Silvia Ebe Lucia Della Pina^1|2, Claudia Barison^1|2, Chiara Orlandi^1|2, Cecilia Nalli¹, Micaela Fredi², Ilaria Cavazzana^1|2, Franco Franceschini^1|2 | ¹Rheumatology and Clinical Immunology Unit- ERN ReCONNET, ASST Spedali Civili of Brescia Brescia, Italy; ²Department of Clinical and Experimental Sciences, University of Brescia Brescia, Italy

Società Italiana di Reumatologia

18-03-2026

https://doi.org/10.4081/reumatismo.2025.2325

27
Association of positive psychological variables with disease activity, functional disability and erythrocyte sedimentation rate in patients with rheumatoid arthritis: a preliminary study

K.C. Meléndez-Monreal, A.J.L. Brambila-Tapia, V. González-Díaz, S. Cerpa-Cruz, S.R. Gutiérrez-Ureña, M.d.C. Yeo-Ayala, R. Robles-García, G.E. Martínez-Bonilla

21-03-2023

https://doi.org/10.4081/reumatismo.2022.1507

1075

PDF: 561

Supplementary file: 131
PO:03:037 | The Impact of Peripheral Joint Involvement, Pain, and Inflammatory Bowel Diseases on Drug Persistence in Axial Psoriatic Arthritis Giuseppe Lopalco¹, Sergio Del Vescovo¹, Maria Sole Chimenti², Giuliana Guggino³, Serena Guiducci⁴, Eleonora Celletti⁵, Alberto Cauli⁶, Luca Cantarini⁷, Valentino Paci⁸, Eneida Cela², Lidia La Barbera³, Gemma Lepri⁴, Myriam Di Penta⁵, Alberto Floris⁶, Alice Agostinelli⁸, Vincenzo Venerito¹, Michele Maria Luchetti⁸, Florenzo Iannone¹ | ¹Rheumatology Unit, Department of Precision and Regenerative Medicine and Ionian Area, Bari, Italy; ²Reumatology, Allergology and Clinical Immunology University of Rome Tor Vergata, Roma, Italy; ³Department of Health Promotion Sciences, Maternal and Infant Care, Internal Medicine and Medical Specialties, Palermo, Italy; ⁴Divisions of Internal Medicine and Rheumatology AOUC, Department of Experimental and Clinical Medicine, Firenze, Italy; ⁵Rheumatology Unit, SS. Annunziata Hospital of Chieti, G. D'Annunzio, Chieti, Italy; ⁶Department of Medical Science and Public Health, Cagliari, Italy; ⁷Policlinico Le Scotte, Siena, Italy; ⁸Clinical Medicine, Dipartimento di Scienze Cliniche e Molecolari, Università Politecnica delle Marche, Ancona, Italy

Società Italiana di Reumatologia

18-03-2026

https://doi.org/10.4081/reumatismo.2025.2292

12
Successful treatment of refractory adult onset Still’s disease with rituximab

N. Belfeki, M. Smiti Khanfir, F. Said, A. Hamzaoui, T. Ben Salem, I. Ben Ghorbel, M. Lamloum, M.H. Houman

159-162

16-12-2016

https://doi.org/10.4081/reumatismo.2016.888

2864

PDF: 1360
The association between serum prolactin levels and interleukin-6 and systemic lupus erythematosus activity

W.A. Wan Asyraf, M.S. Mohd Shahrir, W. Asrul, A.W. Norasyikin, O. Hanita, W.Y. Kong, M.T. Azmi

241-250

20-12-2018

https://doi.org/10.4081/reumatismo.2018.1075

1843

PDF: 1142
PO:15:224 | Measuring disease activity in Systemic Lupus Erythematosus patients: SLE-DAS usefulness in real-life setting Valeria Moretti, Fulvia Ceccarelli, Claudia Ciancarella, Cristina Garufi, Alessandra Ida Celia, Silvia Mancuso, Angelica Gattamelata, Simona Truglia, Francesca Romana Spinelli, Cristiano Alessandri, Fabrizio Conti | La sapienza Università di Roma, Italy

Società Italiana di Reumatologia

18-03-2026

https://doi.org/10.4081/reumatismo.2025.2330

8
CO:05:1 | Predicting one-year disease activity in systemic lupus erythematosus using machine learning and explainable AI Pier Giacomo Cerasuolo¹, Augusta Ortolan¹, Livia Lilli², Laura Antenucci², Carlotta Maschiocchi², Jacopo Lenkowicz², Lucia Lanzo¹, Luca Petricca¹, Maria Rita Gigante¹, Vivianaantonella Pacucci¹, Pierluigi Rizzuti¹, Rebecca Ventura¹, Silvia Piunno¹, Cesare Gavotti¹, Marco Gorini³, Gabriella Castellino³, Alfredo Cesario², Stefano Patarnello², Silvia Laura Bosello¹, Maria Antonietta D'Agostino¹. | ¹UOC di Reumatologia ed Immunologia Clinica, Fondazione Policlinico A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Roma; ²Gemelli Generator, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma; ³AstraZeneca Italy, MIND, Milano, Italy

Società Italiana di Reumatologia

25-11-2025

https://doi.org/10.4081/reumatismo.2025.1970

180
Pregnancy in patients affected by axial-spondyloarthritis: a narrative review of disease activity and obstetric outcomes

M. Filippini, G. Fontana, P. Bizioli, F. Crisafulli, R. Orabona, S. Zatti, F. Franceschini, A. Tincani

11-09-2024

https://doi.org/10.4081/reumatismo.2024.1697

1678

PDF: 684
PO:04:056 | Willingness of patients with psoriatic arthritis to participate in pharmacological and nutritional clinical trials: a cross-sectional study Miriam Perino^1|2, Francesca Ingegnoli^1|2, Luca Ingrao^1|2, Debora Piredu^1|2, Antonio Varvaro^1|2, Camilla Riboldi^1|2, Gilberto Cincinelli², Francesca Desiati², Martina Biggioggero², Orazio De Lucia², Silvia Casari², Maria Manara², Ennio Giulio Favalli^1|2, Roberto Caporali^1|2 | ¹Università degli Studi di Milano, Dipartimento di Scienze Cliniche e di Comunità, Milano; ²ASST G. Pini-CTO, UOC di Clinica Reumatologica, Milano, Italy

Società Italiana di Reumatologia

25-11-2025

https://doi.org/10.4081/reumatismo.2025.2131

129
PO:15:208 | Impact of disease control on organ damage accrual in patients with systemic lupus erythematosus with and extra-renal flares: a 12-month single-center longitudinal study Giorgia Capozzo¹, Marco Oliva¹, Giancarlo Cascarano¹, Chiara Cardelli¹, Dina Zucchi¹, Chiara Stagnaro², Viola Signorini², Elena Elefante², Chiara Tani¹, Marta Mosca¹. | ¹Università di Pisa, Dipartimento di Medicina Clinica e Sperimentale, Pisa, Italy; ²Azienda Ospedaliero Universitaria Pisana, U.O. Reumatologia, Pisa, Italy.

Società Italiana di Reumatologia

25-11-2025

https://doi.org/10.4081/reumatismo.2025.2037

140
CO:10:6 | Impact of pregnancy on organ damage in systemic lupus erythematosus: a prospective multicenter study Giancarlo Cascarano¹, Greta Hulej², Dina Zucchi¹, Antonia Calligaro², Elena Elefante¹, Luca Iaccarino², Sabrina Gori¹, Margherita Zen², Chiara Tani¹, Andrea Doria², Marta Mosca¹. | ¹Università degli Studi di Pisa; ²Università degli Studi di Padova, Italy

Società Italiana di Reumatologia

25-11-2025

https://doi.org/10.4081/reumatismo.2025.1995

131
PO:02:023 | Monocentric analysis of systemic glucocorticoids in PsA: the art of balancing prescriptive appropriateness and risk factor management Chiara Crotti^{1 2}, Gilberto Cincinelli¹, Giorgia Trignani¹³, Luca Ingrao¹³, Miriam Perino¹³, Roberto Caporali¹³ | ¹Dipartimento di Reumatologia e Scienze Mediche - UOC Clinica Reumatologica, ASST Pini-CTO, Milano; ²Dipartimento di Reumatologia e Scienze Mediche - UOC Osteoporosi e Malattie Metaboliche dell Osso - ASST Pini-CTO, Milano; ³Dipartimento di Scienze Cliniche e di Comunità - Università degli Studi di Milano, Italy

Società Italiana di Reumatologia

25-11-2025

https://doi.org/10.4081/reumatismo.2025.2125

160
Real-world experiences of folic acid supplementation (5 versus 30 mg/week) with methotrexate in rheumatoid arthritis patients: a comparison study

K.T. Koh, C.L. Teh, C.K. Cheah, G.R. Ling, M.C. Yong, H.C. Hong, S.C. Gun

90-96

09-09-2016

https://doi.org/10.4081/reumatismo.2016.872

2810

PDF: 1496
The signal transducer and activator of transcription factors lodge in immunopathogenesis of rheumatoid arthritis

F. Zare, M. Dehghan-Manshadi, A. Mirshafiey

127-137

23-05-2016

https://doi.org/10.4081/reumatismo.2015.851

2892

PDF: 1318
Evolution in the use of musculoskeletal ultrasonography in a Rheumatology Unit over 14 years

S. Gil Barato, E. de Miguel Mendieta, E. Martin-Mola

8-12

30-06-2015

https://doi.org/10.4081/reumatismo.2015.792

1667

PDF: 1007
Implication and utility of DAS-28 squeeze in rheumatoid arthritis: an Indian experience

H. Singh, V.S. Tanwar, A. Kalra, A. Saini, S. Arora, N. Govil

13-09-2022

https://doi.org/10.4081/reumatismo.2022.1501

1872

PDF: 978
Neutrophil-lymphocyte ratio, pain perception, and disease activity score may serve as important predictive markers for sustained remission in rheumatoid arthritis

S. Chandrashekara, A. Rajendran, A. Bai Jaganath, R. Krishnamurthy

109-115

09-02-2016

https://doi.org/10.4081/reumatismo.2015.838

3411

PDF: 1578

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