Successful treatment of refractory adult onset Still’s disease with rituximab

Submitted: 29 April 2016
Accepted: 3 August 2016
Published: 16 December 2016
Abstract Views: 1941
PDF: 1128
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Authors

Adult-onset Still’s disease (AOSD) is an uncommon inflammatory condition of unknown origin. In chronic disease, joint involvement is often predominant and erosions are noted in one third of patients. Therapeutic strategies derive from observational data. Corticosteroids are usually the first-line treatment. With inadequate response to corticosteroids, methotrexate appears the best choice to control disease activity and allow for tapering of steroid use. For refractory disease, biological therapy seems the most promising. We report here the case of a 38-year-old female patient with AOSD refractory to cytotoxic agents, treated by rituximab infusion therapy with favorable outcome.

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N. Belfeki, Department of Internal Medicine, University Hospital of La Rabta, Tunis
Department of Internal Medicine. University hospital of la Rabta, Tunis, Tunisia
M. Smiti Khanfir, Department of Internal Medicine, University Hospital of La Rabta, Tunis
Department of Internal Medicine. University hospital of la Rabta, Tunis, Tunisia
F. Said, Department of Internal Medicine, University Hospital of La Rabta, Tunis
Department of Internal Medicine. University hospital of la Rabta, Tunis, Tunisia
A. Hamzaoui, Department of Internal Medicine, University Hospital of La Rabta, Tunis
Department of Internal Medicine. University hospital of la Rabta, Tunis, Tunisia
T. Ben Salem, Department of Internal Medicine, University Hospital of La Rabta, Tunis
Department of Internal Medicine. University hospital of la Rabta, Tunis, Tunisia
I. Ben Ghorbel, Department of Internal Medicine, University Hospital of La Rabta, Tunis
Department of Internal Medicine. University hospital of la Rabta, Tunis, Tunisia
M.H. Houman, Department of Internal Medicine, University Hospital of La Rabta, Tunis
Department of Internal Medicine. University hospital of la Rabta, Tunis, Tunisia

How to Cite

Belfeki, N., Smiti Khanfir, M., Said, F., Hamzaoui, A., Ben Salem, T., Ben Ghorbel, I., … Houman, M. (2016). Successful treatment of refractory adult onset Still’s disease with rituximab. Reumatismo, 68(3), 159–162. https://doi.org/10.4081/reumatismo.2016.888