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PO:07:097 | CGRP and CALCRL localization supports the role of fibroblast-like synoviocytes in rheumatoid arthritis pain pathways Giada La Spina1, Cristina Garufi2, Mattia Caliste2, Martina Leopizzi3, Valeria Di Maio3, Cristiano Alessandri2, Fabrizio Conti2, Francesca Romana Spinelli2 | 1Sapienza University of Rome, Dipartimento di Medicina Molecolare, Roma, Italy; 2Sapienza University of Rome, Dipartimento di Scienze Cliniche Internistiche, Anestesiologiche e Cardiovascolari, Roma, Italy; 3Sapienza University of Rome, Dipartimento di Scienze e Biotecnologie Medico-Chirurgiche, Roma, Italy
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PO:37:263 | First non invasive visualization of vasculitis in the retinal arteries by high resolution optical coherence tomography in a patient with giant cell arteritis Ruggiero Mascolo1, Chiara Facoetti1, Claudia Nardi2, Stefano Erba2, Martina Martelli1, Gabriella Marinaro1, Giulia Dieguez1, Giacomo Iacomelli1, Chiara Carollo1, Michel Chevallard3, Bruno Lucchino3, Mariaeva Romano3, Andrea Locatelli3, Donatella Ventura3, Giovanna Randisi3, Giuliana La Paglia3, Alessandra Mutti3, Alessandro Invernizzi2, Stefano De Angelis2, Giovanni Staurenghi2, Antonio Brucato4, Enrico Tombetti4. | 1Dipartimento di Medicina Interna, ASST Fatebenefratelli-Sacco, Università degli studi di Milano, Milano, Italy; 2U.O. Oftalmologia, ASST Fatebenefratelli-Sacco, Università degli studi di Milano, Milano, Italy; 3U.O. Reumatologia, ASST Fatebenefratelli-Sacco, Università degli studi di Milano, Milano, Italy; 4Dipartimento di scienze cliniche e biomediche, ASST Fatebenefratelli-Sacco, Università degli studi di Milano, Milano, Italy.
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PO:35:222 | Distinctive Features of Localized Vasculitis of the Gastrointestinal Tract Compared to Takayasu Arteritis: Insights from a Multicenter Cohort Study Vittorio Dibenedetto1|2|3, Alessandro Tomelleri1|2, Corrado Campochiaro1|2, Elena Baldissera1|2, Luca Moroni1|2, Padoan Roberto4, Marco Matucci-Cerinic1|2|3, Lorenzo Dagna1|2|3 | 1Unit of Immunology, Rheumatology, Allergy and Rare Diseases UNIRAR, IRCCS San Raffaele Hospital Milan, Italy; 2Inflammation, Fibrosis and Ageing Intitiative INFLAGE, IRCCS San Raffaele Hospital Milan, Italy; 3Vita-Salute San Raffaele University, Milan, Italy Milan, Italy; 4University Hospital of Padova, Department of Internal Medicine and Rheumatology Padova, Italy
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CO:12:5 | Aortic inflammation and aneurysm risk in giant cell arteritis: a multicenter imaging study Caterina Ricordi1, Chiara Marvisi1, Konstanze V. Guggenberger2, Rudolf A. Werner3, Pamela Mancuso8, Giulia Besutti4, Sebastian E. Serfling5, Roberto Farì4, Matthias Frohlich6, Rexhep Durmo7, Michael Gernert6, Lucia Spaggiari4, Annibale Versari7, Paolo Giorgi Rossi8, Pierpaolo Pattacini4, Marc Schmalzing6, Carlo Salvarani1, Thorsten Bley9, Francesco Muratore1. | 1Rheumatology Unit, AUSL IRCCS di Reggio Emilia and Università di Modena e Reggio Emilia, Italy; 2Department of Diagnostic and Interventional Neuroradiology, University Hospital Wuerzburg, Germany; 3Department of Nuclear Medicine, University of Frankfurt, Germany; 4Department of Radiology, AUSL IRCCS di Reggio Emilia, Italy; 5Department of Nuclear Medicine, University Hospital Wuerzburg, Germany; 6Rheumatology and Clinical Immunology, Department of Internal Medicine II, University Hospital Wuerzburg, Germany; 7Nuclear Medicine Unit, AUSL IRCCS di Reggio Emilia, Italy; 8Epidemiology Unit, AUSL-IRCCS di Reggio Emilia, Italy; 9Department of Diagnostic and Interventional Radiology, University Hospital Wuerzburg, Germany
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PO:36:253 | Lifestyle and Behçet's syndrome: a preliminary study on gender differences Pietro Leccese1, Angela Anna Padula1, Nancy Lascaro1, Salvatore D'Angelo1, Maria Carmela Padula1 | 1UOC Reumatologia AOR San Carlo, Potenza, Italy
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PO:22:033 | Unraveling VEXAS syndrome: when skin manifestations and monoclonal gammopathy precede hematological myeloid alterations Laura Di Centa1, Simone Longhino1, Valeria Manfrè1, Stefania Sacco1, Luca Quartuccio1 | 1ASST Papa Giovanni XXIII, Bergamo, Italy
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PO:01:007 | Modulation of cellular senescence in psoriatic arthritis: exploring the potential impact of b/tsDMARDs treatment on telomere length, mtDNA copy number, and oxidative damage Eneida Cela1, Giada De Benedittis2, Arianna D'Antonio1, Andrea Latini3, Chiara Morgante2, Cinzia Cicacci3, Paola Conigliaro1, Mauro Fatica1, Giulia Mori1, Giuseppe Novelli2, Paola Borgiani2, Maria Sole Chimenti1. | 1Rheumatology, Allergology and Clinical Immunology, Department of System Medicine, University of Rome Tor Vergata, Rome, Italy; 2Department of Biomedicine and Prevention, Section of Genetics, University of Rome Tor Vergata, Rome, Italy; 3UniCamillus Saint Camillus International University of Health Sciences, Rome, Italy.
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PO:37:266 | Long-term manifestation of graft-versus-host disease presenting as a vasculitic-like syndrome: a rare case report Camilla Mazzanti1, Gianluca Santoboni1, Claudio Angrisani1, Massimiliano De Simone1, Giuliana Marciani1, Alessandra Fiorentini1 | 1Ospedale Santa Rosa Viterbo, Italy
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PO:02:027 | Fast food, slow damage: ultra-processed foods, Western diet and inflammatory arthritis. A systematic scoping review Gianluca Poncina1, Federica Gardin2, Giacomo Cozzi1, Laura Scagnellato1, Mariagrazia Lorenzin1, Stefano Rizzetto1, Caterina Robusto1, Francesca Oliviero1, Valérie Tikhonoff2, Roberta Ramonda1. | 1Rheumatology Unit, Department of Medicine-DIMED, University - Padova University Hospital, Padova, Italy; 2Department of Medicine-DIMED, University - Padova University Hospital, Padova, Italy.
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PO:31:167 | Increased M2 pro-fibrotic marker expression in circulating monocytes and cultured monocyte-derived macrophages in systemic sclerosis patients with progressive interstitial lung disease Vanessa Smith1|2, Stefano Soldano3, Rosanna Campitiello3|5, Emanuele Gotelli3|4, Paola Montagna3, Elvis Hysa3|5, Tamara Vojinovic3|4, Carmen Pizzorni3|4, Sabrina Paolino3|4, Alberto Sulli3|4, Maurizio Cutolo3|4. | 1Department of Internal Medicine and Department of Rheumatology, Ghent University Hospital, Ghent, Belgium; 2Unit for Molecular Immunology and Inflammation, VIB Inflammation Research Centre, Ghent, Belgium; 3Laboratory of Experimental Rheumatology and Academic Division of Clinical Rheumatology, Department of Internal Medicine, Genova, Italy; 4IRCCS Ospedale Policlinico San Martino, Genova, Italy; 5Department of Experimental Medicine DIMES, University of Genova, Genova, Italy.
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PO:11:172 | Not all vasculitis look the same: a difficult diagnosis Marta Arese1|2, Miriam Perino1|2, Sofia Aliprandi1|2, Antonella Murgo2, Maria Gerosa1|2, Roberto Felice Caporali1|2 | 1UOC Reumatologia AOR San Carlo, Potenza; 2Reumatologia Clinica, ASST Gaetano Pini-CTO, Milano, Italy
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S02:6 | Monocyte-Driven Inflammation and Inflammasome Activation in ANCA-Positive EGPA: Evidence of Persistent Immune Activation During Remission Chiara Baggio1, Luca Iorio1, Carlotta Boscaro2|3, Federica Davanzo1, Marta Tonello1, Mattia Albiero4, Andrea Doria1, Paolo Sfriso1, Roberto Padoan1, Francesca Oliviero1 | 1Rheumatology Unit, Department of Medicine, University of Padova, Italy; 2Department of Medicine, University of Padova, Italy; 3Veneto Institute of Molecular Medicine, Laboratory of Experimental Diabetology, Italy; 4Department of Surgery, Oncology, and Gastroenterology, University of Padova, Italy
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PO:03:035 | Biomarkers of Gut Epithelial Damage, Microbial Translocation, and Innate Immune Activation Characterize Patients with Axial Psoriatic Arthritis from Psoriasis Patients: Soluble Biomarker Analysis Insights from the ATTRACT Study Giulia Marchionni1, Valentino Paci1, Silvia Svegliati1, Raffaella Sordillo1, Federico Fiorini1, Melania Giannoni1, Anna Campanati1, Raissa Di Zio1, Devis Benfaremo1, Giuseppe Lopalco2, Florenzo Iannone2, Ennio Lubrano3, Alberto Cauli4, Gianluca Moroncini1, Dennis Poddubnyy5, Fabian Proft6, Michele M Luchetti Gentiloni1 | 1Marche Polytechnic University and Azienda Ospedaliero-Universitaria delle Marche, Ancona, Italy; 2University of Bari, Bari, Italy; 3Molise University, Campobasso, Italy; 4University of Cagliari, Azienda Ospedaliero Universitaria di Cagliari, Monserrato, Italy; 5University of Toronto, Toronto, Canada; 6Charité-Universitätsmedizin, Berlino, Germany
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PO:28:128 | Rheumatic fever: an atypical case Giovanni Italiano1, Melania Coscia1, Arianna Monteforte1 | 1AORN S. Anna e S. Sebastiano Caserta, Italy
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PO:33:201 | Metabolic and functional state of circulating platelets in patients with systemic sclerosis Annalisa Villa1, Simona Truglia1, Francesca Maiorca2, Annamaria Sabetta2, Ludovica Lombardi2, Silvia D'Orso2, Lucia Stefanini2, Fabrizio Conti1, Marcella Visentini2, Valeria Riccieri1 | 1Dipartimento di Scienze Cliniche, Internistiche, Anestesiologiche e Cardiovascolari, Università degli Studi di Roma La Sapienza; 2Dipartimento di Medicina Traslazionale e di Precisione, Università degli Studi di Roma La Sapienza
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PO:15:212 | Anifrolumab induces a rapid improvement in joint inflammation in Systemic Lupus Erythematosus patients: an ultrasonographic study Valeria Moretti, Fulvia Ceccarelli, Claudia Ciancarella, Valerio Fiorilli, Francesca Romana Spinelli, Fabrizio Conti | Sapienza Università di Roma, Italy
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CO:05:3 | Radiomics and machine learning for differentiating rheumatoid arthritis-associated interstitial lung disease and idiopathic pulmonary fibrosis with usual interstitial pneumonia pattern Vincenzo Venerito1, Chiara Nani2, Andreina Manfredi3, Marco Fornaro1, Giuseppe Lopalco1, Florenzo Iannone1, Cecilia Burattini2, Marco Sebastiani4. | 1Rheumatology Unit, University of Bari; 2Respiratory Unit, Guglielmo da Saliceto Civil Hospital, Piacenza; 3Rheumatology Unit, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia; 4Rheumatology Unit, AUSL Piacenza, University of Parma, Italy
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PO:06:092 | Early achievement of remission confers better outcomes than low disease activity in both seropositive and seronegative patients with new-onset rheumatoid arthritis Clelia Zampaglione1|2, Ludovico De Stefano1|2, Federica Sabatelli1|2, Alessio D'Isanto1|2, Blerina Xoxi1|2, Antonio Manzo1|2, Carlomaurizio Montecucco1|2, Serena Bugatti1|2. | 1Department of Internal Medicine and Therapeutics, University of Pavia, Pavia; 2Division of Rheumatology, IRCCS Policlinico San Matteo Foundation, Pavia, Italy.
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PO:36:246 | Early real-world outcomes with benralizumab in eosinophilic granulomatosis with polyangiitis: a monocentric retrospective Richard Borrelli1, Stefania Nicola1, Federica Corradi1, Iuliana Badiu1, Marzia Boem1, Valentina Marmora1, Simone Negrini1, Luisa Brussino1. | 1SCDU Immunologia e Allergologia, AO Mauriziano, Dipartimento di Scienze Mediche, Università degli Studi di Torino, Torino, Italy.
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PO:07:098 | Reasons for treatment failure and their synovial correlate among patients with difficult-to-treat rheumatoid arthritis Alessandro Giollo1, Mariangela Salvato1, Francesca Frizzera1, Kiren Khalid1, Lorenzo Di Luozzo1, Carlo Garaffoni2, Maria Capita2, Marianna Tamussin2, Giovanni Lanza2, Marny Fedrigo3, Annalisa Angelini3, Roberta Ramonda1, Ettore Silvagni2, Andrea Doria1 | 1UOC Reumatologia Padova, Italy; 2UOC Reumatologia Ferrara, Italy; 3UOC Patologia cardiovascolare Padova, Italy; 4UOC Anatomia Patologica Ferrara, Italy
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PO:30:157 | Radiographic assessment of measurable osteoarticular damage in juvenile idiopathic arthritis (JIA) patients transitioning to adult care Serena Pastore4, Marta Klanmjsceck3, Andrea Guiotto1, Laura De Nardi5|6, Alessia Pin4, Lorenzo Cereser1|2, Andrea Taddio3|4, Luisa Occhipinti1, Luca Quartuccio1|2, Alberto Tommasini3|4, Alen Zabotti2 | 1Università degli Studi di Udine Udine, Italy; 2Ospedale Santa Maria della Misericordia Udine, Italy; 3Università degli Studi di Trieste Trieste, Italy; 4IRCCS Materno Infantile Burlo Garofolo Trieste, Italy; 5Università Tor Vergata Roma, Italy; 6Ospedale Pediatrico Bambino Gesù Roma, Italy
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PO:31:175 | Characterizing gastrointestinal involvement in systemic sclerosis: insights from the national systemic sclerosis progression investigation registry of the Italian Society of Rheumatology Francesco Bonomi1, Cosimo Bruni1|2, Silvia Laura Bosello3, Fabio Cacciapaglia4|5, Corrado Campochiaro6, Roberto Caporali7, Veronica Codullo8, Maria Antonietta D'Agostino3, Lorenzo Dagna6, Rossella De Angelis9, Giacomo De Luca6, Dilia Giuggioli10, Serena Guiducci1, Florenzo Iannone4, Francesca Ingegnoli7, Carlomaurizio Montecucco8, Valeria Riccieri11, Clodoveo Ferri10, Marco Matucci Cerinic6, Silvia Bellando Randone1. | 1Scleroderma Unit, Division of Rheumatology AOUC, and Department of Experimental and Clinical Medicine, Uni. of Florence, Firenze, Italy; 2Department of Rheumatology, University Hospital Zurich, University of Zurich Zurigo Switzerland; 3UOC of Rheumatology and Clinical Immunology, Catholic University of the Sacred Heart, Fondazione Policlinico A. Gemelli, Roma, Italy; 4Rheumatology Unit, Department of Emergency Surgery and Organ Transplantations, University of Bari, Bari, Italy; 5Rheumatology Service, F. Miulli General Hospital - Department of Medicine and Surgery, LUM 'G. De Gennaro', Casamassima, Italy; 6Unit of Immunology, Rheumatology, Allergy and Rare Diseases and Inflammation, fibrosis and ageing initiative, UniSR, Milano, Italy; 7Division of Clinical Rheumatology, ASST Pini and Università degli studi di Milano, Milano, Italy; 8Department of Rheumatology, Policlinico San Matteo, Pavia, Italy; 9Rheumatology Unit, Department of Clinical and Molecular Sciences, Polytechnic University of Marche, Ancona, Italy; 10Rheumatology Unit, School of Medicine, University of Modena and Reggio Emilia, Modena, Italy; 11Department of Rheumatology, Sapienza University of Rome, Roma, Italy.
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PO:02:022 | Bimekizumab Maintained Stringent Clinical Responses over 2 Years in Patients with Axial Spondyloarthritis: Results from Two Phase 3 Studies Fabian Proft1, Désirée Van Der Heijde2, Sergio Schwartzman3|4|5, Joerg Ermann6, Alexander Marten7, Ute Massow7, George Stojan8, Vanessa Taieb9, Diana Voiniciuc10, Astrid Van Tubergen11, Victoria Navarro-Compán12, Simone Angioni13, Xenofon Baraliakos14 | 1Charité-Universitätsmedizin Berlin; Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; 2Department of Rheumatology, Leiden University Medical Center Leiden, The Netherlands; 3Weill Cornell Medical Center New York, USA; 4New York Presbyterian Hospital New York, USA; 5Hospital for Special Surgery New York, USA; 6Division of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital and Harvard Medical School Boston, USA; 7UCB Monheim am Rhein Germany; 8UCB Atlanta, USA; 9UCB Colombes, France; 10UCB Slough, United Kingdom; 11Department of Medicine, Division of Rheumatology, Maastricht University Medical Center Maastricht, The Netherlands; 12Department of Rheumatology, La Paz University Hospital, IdiPaz Madrid, Spain; 13UCB Milan, Italy; 14Rheumazentrum Ruhrgebiet Herne, Ruhr-University Bochum, Germany
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CO:01:2 | BAG3 in systemic sclerosis: possible therapeutic target and biomarker for pulmonary fibrosis Claudia Iannone1|2, Margot De Marco3, Antonina Minniti1, Paola Manzo3, Angela D'Ardia3, Antonia Falco3, Liberato Marzullo3, Angela Rosato3, Maria Caterina Turco3, Roberto Caporali1|2, Nicoletta Del Papa1|2. | 1ASST G. Pini-CTO. UOC Clinica Reumatologica, Milano; 2Department of Clinical Sciences and Community Health, University of Milano; 3Department of Medicine, Surgery and Dentistry Schola Medica Salernitana, Baronissi (SA), Italy
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