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CO:03:3 | Contribution of mitochondrial DNA to the onset and maintenance of inflammation in Systemic Sclerosis patients Martina Orlandi1, Giorgia Sinigaglia2, Amelia Spinella1, Isabella Martusciello2, Marco De Pinto1, Giorgia Roveta1, Luca Keller1, Marcello Pinti2, Dilia Giuggioli1 | 1Dipartimento di scienze mediche e chirurgiche dei bambini e degli adulti, Università di Modena e Reggio Emilia, Italy; 2Università degli Studi di Modena e Reggio Emilia, Italy
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PO:09:134 | The impact of intra-articular hyaluronic acid injections on osteoarthritis synovitis: a study on synovial tissue of total knee arthroplasty patients Orazio De Lucia1, Laura Giudice1|2, Carolina Artusi1, Luca Ingrao1|2, Giorgia Trignani1|2, Matteo Ferrito1, Andrea Amati1|2, Marta Arese1|2, Camilla Riboldi1|2, Isabella Scotti1, Antonella Murgo1, Ennio Giulio Favalli1|2, Antonina Parafioriti3, Elisabetta Armiraglio3, Andrea Di Bernardo3, Filippo Calanna4, Chiara Fossati4, Pietro Simone Randelli4|5, Roberto Felice Caporali1|2 | 1Dipartimento di Reumatologia e Scienze Mediche,ʁSST Centro Specialistico Ortopedico Traumatologico Gaetano Pini-CTO, Milano; 2Dipartimento di Scienze Cliniche e di Comunità, Università degli Studi di Milano; 3UOC Anatomia Patologica, ASST Centro Specialistico Ortopedico Traumatologico Gaetano Pini-CTO, Milano; 4UOC 1° Clinica Ortopedica, ASST Centro Specialistico Ortopedico Traumatologico Gaetano Pini-CTO, Milano; 5Università degli Studi di Milano, Dipartimento di Scienze Biomediche per la Salute, Milano, Italy
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PO:12:177 | Systemic inflammation and QTc interval prolongation in new-onset polymyalgia rheumatica: the effect of corticosteroid therapy Anna Colangelo1, Riccardo Accioli2, Viola Salvini2, Francesco Tromby1, Giulia Cruciani1, Martina Nicchi1, Biancamaria Pianese1, Francesca Lalli1, Anna Cantore2, Caterina Antonini1, Decoroso Verrengia2, Andrea Castellucci1, Giacomo Cafaro1, Carlo Perricone1, Roberto Gerli1, Pietro Enea Lazzerini2, Elena Bartoloni1 | 1SC Reumatologia. Università di Perugia, Italy; 2Dipartimento di Scienze Mediche, Università di Siena, Italy
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PO:06:094 | Exploring the relationship between inflammation and collagen deposition in synovial tissue and clinical outcomes in active arthritis: insights from a monocentric pilot study Dario Bruno1, Barbara Tolusso1, Daniela Renna1, Mohamed Hegazi2, Fabio Pasqualini2, Marta Caprioli1, Giacomo Maria Guidelli1, Tommaso Hubert3, Nicoletta Luciano1|3, Marzia Monferini3, Natasa Isailovic3, Fabio Grizzi2|3, Salvatorelorenzo Renne3, Costantino Pitzalis1|3|4, Elisa Gremese1|3. | 1Rheumatology and Clinical Immunology, IRCCS Humanitas Research Hospital, Rozzano (MI); 2Department of Immunology and Inflammation, IRCCS Humanitas Research Hospital, Milano; 3Department of Biomedical Sciences, Humanitas University, Rozzano (MI), Italy; 4Centre for Experimental Medicine and Rheumatology, Queen Mary University of London, London, UK
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CO:08:1 | Aquaporin-4 downregulation in dysphagic idiopathic inflammatory myopathies: association with Type 2 fiber damage and inflammation Marco Fornaro1, Margherita Giannini2, Dario D'Abbicco3, Maria Luisa Fiorella4, Antonio Frigeri5, Francesco Girolamo6, Florenzo Iannone1. | 1Unit of Rheumatology, Department of Precision and Regenerative Medicine and Ionian Area, Bari, Italy; 2Physiologie et Explorations Fonctionnelles Musculaires, University Hospital of Strasbourg, Strasburgo, France; 3Institute of General Surgery G Marinaccio, Department of Precision and Regenerative Medicine and Ionian Area, Bari; 4Unit of Otolaryngology, Department of Translational Biomedicine and Neuroscience DiBraiN, Bari; 5Unit of Human Physiology, Department of Translational Biomedicine and Neuroscience DiBraiN, Bari; 6Unit of Human Anatomy and Histology, Department of Translational Biomedicine and Neuroscience DiBraiN, Bari, Italy
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PO:01:014 | Differential inflammatory responses of CD14+ and CD14– synoviocytes in psoriatic arthritis: implications for pathogenesis and targeted therapies Monia Maccaferri1, Monica Montanari2, Francesco Zambianchi3|4, Carlo Salvarani1|5, Elisa Pignatti1|4 | 1Dipartimento CHIMOMO; 2Dipartimento di Scienze e Vita; 3Dipartimento SMECHIMAI Università di Modena e Reggio Emilia; 4Azienda Ospedaliero Universitaria di Modena; 5Struttura Complessa di Reumatologia, Azienda Unità Sanitaria Locale di Reggio Emilia-IRCCS, Italy
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CO:07:3 | Does articular and entheseal structural damage drive pain and patient-driven reported outcomes in difficult-to-treat psoriatic arthrtis patients? Results from a cross-sectional study Fabio Massimo Perrotta1, Alen Zabotti2, Mauro Fatica1, Nicola Cabas2, Andrea Guiotto2, Nicoletta Franzolini3, Giovanni Striani2, Maria De Martino4, Cristina De Nicola5, Miriam Isola4, Andrea Di Matteo6, Gabriele De Marco6, Denis McGonagle6, Ennio Lubrano1, Luca Quartuccio4. | 1Università degli studi del Molise, Campobasso; 2University Hospital Santa Maria della Misericordia, Udine; 3Presidio Ospedaliero S. Antonio, San Daniele del Friuli (UD); 4University of Udine; 5Epidemiology Unit, Italian Society for Rheumatology, Milano, Italy; 6University of Leeds, Leeds, UK
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CO:10:1 | High-grade synovitis and histological pathotype distribution in patients with advanced osteoarthritis undergoing joint replacement: a more inflammatory disease than we thought? Jacopo Ciaffi1, Lorenzo Bianchi1, Luana Mancarella2, Federica Pignatti2, Veronica Brusi2, Lucia Lisi2, Simona Neri2, Elisa Assirelli2, Alberto Righi3, Marco Gambarotti3, Francesco Ursini1. | 1SSD Medicina e Reumatologia, IRCCS Istituto Ortopedico Rizzoli, Alma Mater Studiorum Università di Bologna; 2SSD Medicina e Reumatologia, IRCCS Istituto Ortopedico Rizzoli, Bologna; 3SSD di Anatomia e Istologia Patologica, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy
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PO:20:012 | Inflammatory markers and nutritional status in patients with osteoporotic fractures: preliminary analysis of a pilot study Domenico Birra1, Manuela Maione2, Carolina Bologna1, Carmela Pierce2, Paolo Tirelli1, Gianluigi Cuomo1, Carolina Sepe2, Pasquale Madonna1, Claudio De Luca1, Federica Coretti2, Vincenzo Nuzzo1 | 1S.C. Reumatologia, ASST Grande Ospedale Metropolitano Niguarda, Milano, Italy; 2U.O.S.D. Malattie Endocrine del ricambio e della nutrizione - P. O. Ospedale del Mare - Asl Napoli 1 centro, Napoli, Italy
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PO:37:257 | Giant cell arteritis debuting with aortic involvement: the importance of integrated diagnostics in fever of unknown origin Alessandro Gratton1, Giovanni Striani1, Luisa Occhipinti1, Stefania Sacco1, Enrico Pegolo2, Luca Quartuccio1 | 1Rheumatology Clinic and 2 Institute of Anatomical Pathology, Department of Laboratory Medicine, University of Udine, Hospital “Santa Maria della Misericordia”, Udine, Italy
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PO:21:021 | The eyes tell the story: a clinical case of Rosah syndrome Nicolò Sabbion1, Sofia Vitale1, Claudia Balicchia1, Barbara Troise1, Francesca Mascia1, Eleonora Bassanello2, Jacopo Croce2, Federica Maiolini2, Filippo Mazzi2, Elisa Tinazzi2, Francesca Bosello1, Simonetta Friso1, Lucia De Franceschi1 | 1Università degli Studi di Verona; 2Azienda Ospedaliera Universitaria Integrata, Verona, Italy
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PO:01:011 | Achievement of Remission Defined by Absence of Objective Signs of Inflammation Versus ASDAS ID in Patients with Active Axial Spondyloarthritis Treated with Bimekizumab: 52-Week Results from Two Phase 3 Studies Lianne S Gensler1, Helena Marzo-Ortega2, Vanessa Taieb3, Diana Voiniciuc4, Alexander Marten5, George Stojan6, Mindy Kim6, Paolo Marsico7, Martin Rudwaleit8 | 1Department of Medicine/Rheumatology, University of California San Francisco, USA; 2NIHR Leeds Biomedical Research Centre, University of Leeds Leeds, United Kingdom; 3UCB Colombes, France; 4UCB Slough, United Kingdom; 5UCB Monheim am Rhein Germany; 6UCB Atlanta, USA; 7UCB Milan, Italy; 8University of Bielefeld, Klinikum Bielefeld Bielefeld Germany
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PO:05:069 | Risankizumab efficacy in peripheral and axial involvement: monocentric experience Roberta Foti1, Ylenia Dal Bosco1, Giorgio Amato1, Elisa Visalli1, Francesco De Lucia1, Gabriella Paolí1, Rosario Foti1. | 1UOSD Reumatologia AOU Policlinico G. Rodolico-S. Marco, Catania, Italy.
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PO:26:095 | Educational online webinars of European Reference Network on rare and complex connective tissue and musculoskeletal diseases for patients, caregivers and healthcare professionals: six years' experience Emanuele Gotelli1|2, Rosanna Campitiello1|3, Eric Hachulla4|5|6, Vanessa Smith7|8|9, Joao Eurico Fonseca10|11, Tadej Avcin12|13, Gabriele Simonini14|15, Silvia Aguilera16, Lisa Matthews17, Charissa Frank18, Wiebke Lautré19, Monica Testoni20, Diana Marinello20, Rosaria Talarico20, Marta Mosca20, Maurizio Cutolo1|2. | 1Department of Internal Medicine and Specialties, University of Genova, Genova, Italy; 2IRCCS Ospedale Policlinico San Martino, Genova, Italy; 3Department of Experimental Medicine DIMES, University of Genova, Genova, Italy; 4Institute for Translational Research in Inflammation INFINITE, Université de Lille, Lille, France; 5INSERM, Lille, France; 6Centre de référence des maladies autoimmunes systemiques rares du Nord et Nord-Ouest de France CeRAINO, Lille, France; 7Department of Internal Medicine, University of Ghent, Ghent University Hospital, Ghent, Belgium; 8Department of Rheumatology, University of Ghent, Ghent University Hospital, Ghent, Belgium; 9Unit for Molecular Immunology and Inflammation, Flemish Institute for Biotechnology, Inflammation Research Center, Ghent, Belgium; 10Centro Hospitalar Universitário Lisboa Norte EPE, Serviço de Reumatologia e Doenças Ósseas Metabólicas Lisboa Portugal; 11Universidade de Lisboa, Unidade de Investigação em Reumatologia, Instituto de Medicina Molecular João Lobo Antunes Lisboa Portugal; 12University Children Hospital, University Medical Center Ljubljana, Ljubljana, Slovenia; 13University of Ljubljana, Department of Paediatrics, Ljubljana, Slovenia; 14University of Florence, NEUROFARBA Department, Firenze, Italy; 15Meyer Children Hospital IRCCS, Rheumatology Unit, Firenze, Italy; 16Spanish Association for Antiphospholipid Syndrome, Elche, Spain; 17Relapsing Polychondritis Awareness and Support, Worcester, United Kingdom; 18Flemish Association for Hereditary Connective Tissue Disorders, Koersel, Belgium; 19CHU Bordeaux Pellegrin, Centre de Références Maladies Auto-Immunes Systémiques Rares, Bordeaux, France; 20Azienda Ospedaliero Universitaria Pisana, Pisa, Italy.
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PO:11:158 | Osteomyelitis of the jaw: a rare mimick of giant cell arteritis Laura Gigante1, Giovanni B. Canestrari1, Olga Addimanda1, Francesca Bergossi1, Angela Buffa1, Francesco Cianci1, Daniela Chiarini1, Niccolò Girolimetto1, Daniele Lini1, Luca Magnani1, Mirco Magnani1, Erika Meleddu1, Francesca Pignataro1, Sofia Testoni1, Alarico Ariani1, Rita Mulè1, Elisa Rossi1, Enrica Vandelli1, Gentiana Vukatana1, Antonella Gamberini1, Massimo Reta1 | 1UO interaziendale Medicina Interna ad Indirizzo Reumatologico - AUSL Bologna - AOSP Sant'Orsola Bologna, Italy
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PO:35:222 | Distinctive Features of Localized Vasculitis of the Gastrointestinal Tract Compared to Takayasu Arteritis: Insights from a Multicenter Cohort Study Vittorio Dibenedetto1|2|3, Alessandro Tomelleri1|2, Corrado Campochiaro1|2, Elena Baldissera1|2, Luca Moroni1|2, Padoan Roberto4, Marco Matucci-Cerinic1|2|3, Lorenzo Dagna1|2|3 | 1Unit of Immunology, Rheumatology, Allergy and Rare Diseases UNIRAR, IRCCS San Raffaele Hospital Milan, Italy; 2Inflammation, Fibrosis and Ageing Intitiative INFLAGE, IRCCS San Raffaele Hospital Milan, Italy; 3Vita-Salute San Raffaele University, Milan, Italy Milan, Italy; 4University Hospital of Padova, Department of Internal Medicine and Rheumatology Padova, Italy
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CO:12:5 | Aortic inflammation and aneurysm risk in giant cell arteritis: a multicenter imaging study Caterina Ricordi1, Chiara Marvisi1, Konstanze V. Guggenberger2, Rudolf A. Werner3, Pamela Mancuso8, Giulia Besutti4, Sebastian E. Serfling5, Roberto Farì4, Matthias Frohlich6, Rexhep Durmo7, Michael Gernert6, Lucia Spaggiari4, Annibale Versari7, Paolo Giorgi Rossi8, Pierpaolo Pattacini4, Marc Schmalzing6, Carlo Salvarani1, Thorsten Bley9, Francesco Muratore1. | 1Rheumatology Unit, AUSL IRCCS di Reggio Emilia and Università di Modena e Reggio Emilia, Italy; 2Department of Diagnostic and Interventional Neuroradiology, University Hospital Wuerzburg, Germany; 3Department of Nuclear Medicine, University of Frankfurt, Germany; 4Department of Radiology, AUSL IRCCS di Reggio Emilia, Italy; 5Department of Nuclear Medicine, University Hospital Wuerzburg, Germany; 6Rheumatology and Clinical Immunology, Department of Internal Medicine II, University Hospital Wuerzburg, Germany; 7Nuclear Medicine Unit, AUSL IRCCS di Reggio Emilia, Italy; 8Epidemiology Unit, AUSL-IRCCS di Reggio Emilia, Italy; 9Department of Diagnostic and Interventional Radiology, University Hospital Wuerzburg, Germany
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PO:36:253 | Lifestyle and Behçet's syndrome: a preliminary study on gender differences Pietro Leccese1, Angela Anna Padula1, Nancy Lascaro1, Salvatore D'Angelo1, Maria Carmela Padula1 | 1UOC Reumatologia AOR San Carlo, Potenza, Italy
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PO:22:033 | Unraveling VEXAS syndrome: when skin manifestations and monoclonal gammopathy precede hematological myeloid alterations Laura Di Centa1, Simone Longhino1, Valeria Manfrè1, Stefania Sacco1, Luca Quartuccio1 | 1ASST Papa Giovanni XXIII, Bergamo, Italy
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