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S02:6 | Monocyte-Driven Inflammation and Inflammasome Activation in ANCA-Positive EGPA: Evidence of Persistent Immune Activation During Remission Chiara Baggio1, Luca Iorio1, Carlotta Boscaro2|3, Federica Davanzo1, Marta Tonello1, Mattia Albiero4, Andrea Doria1, Paolo Sfriso1, Roberto Padoan1, Francesca Oliviero1 | 1Rheumatology Unit, Department of Medicine, University of Padova, Italy; 2Department of Medicine, University of Padova, Italy; 3Veneto Institute of Molecular Medicine, Laboratory of Experimental Diabetology, Italy; 4Department of Surgery, Oncology, and Gastroenterology, University of Padova, Italy
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PO:35:227 | Long-term renal and survival outcomes in microscopic polyangiitis: data from an observational monocentric cohort Roberta Prevedello1, Federica Davanzo1, Luca Iorio1, Eleonora Fiorin1, Marta Codirenzi1, Roberto Padoan1, Andrea Doria1. | 1Unità di Reumatologia, Dipartimento di Medicina DIMED, Università degli Studi di Padova, Padova, Italy.
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PO:37:268 | Antineutrophil cytoplasmic antibodies-associated vasculitis mimicking giant cell arteritis: a diagnostic dilemma Bruno Biasi1, Elena Vanni1, Marco De Pinto2, Giulia Cassone2, Dilia Giuggioli1|2. | 1Rheumatology Unit, School of Medicine, University of Modena and Reggio Emilia, Modena, Modena, Italy; 2Rheumatology Unit, Azienda Ospedaliera-Universitaria Policlinico di Modena, Modena, Italy, Modena, Italy.
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PO:37:258 | Neutrophil and eosinophil extracellular traps in eosinophilic granulomatosis with polyangiitis: phenotype-based characterization and response to mepolizumab Michele Moretti1, Francesco Ferro2, Francesco Pisani1, Elisa Ferrigno1, Gaetano La Rocca1, Federica Di Cianni3, Rosaria Talarico2, Marta Mosca1, Chiara Baldini1, Ilaria Puxeddu1. | 1University of Pisa - Department of Clinical and Experimental Medicine, Pisa, Italy; 2Azienda Ospedaliero Universitaria Pisana - Rheumatology Unit, Pisa, Italy; 3University of Siena, Siena, Italy.
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PO:35:234 | Sustained Vasculitis Quiescence and CS Reduction with Mepolizumab 100 mg Francesca Mascia1, Angelo Fassio2, Marco Zurlo1, Davide Chesini3, Francesco Pollastri2, Giovanni Adami2, Davide Gatti4, Maurizio Rossini4, Matteo Maule5, Gianentrico Senna1, Marco Caminati1 | 1University of Verona - Allergology and Clinical Immunology Verona, Italy; 2Policlinico G. B. Rossi - Rheumatology Verona, Italy; 3University of Verona - Faculty of Medicine and Surgery Verona, Italy; 4University of Verona - Rheumatology Verona, Italy; 5Policlinico G. B. Rossi - Allergology and Clinical Immunology Verona, Italy
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PO:37:269 | Intensive therapeutic plasma exchange in life-threatening ANCA-associated vasculitis Davide Bertelle, Riccardo Bixio, Francesco Pollastri, Maurizio Rossini, Angelo Fassio, Alessandro Giollo | Unità di Reumatologia, Dipartimento di Medicina Clinica e Sperimentale, Università di Pisa
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PO:37:267 | Mimickers of polyarteritis nodosa: a case of segmental arteriolar mediolysis Filippo Santoro1, Caterina Vacchi2, Giulia Cassone2, Maria Grazia Malandra1, Dilia Giuggioli1|2 | 1UOSD Reumatologia, Ospedale San Camillo De Lellis, Rieti; 2UOC Igiene e Sanità Pubblica, ASL Rieti; 3Direzione Sanitaria, ASL Rieti, Italy
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PO:36:238 | Clinical, functional, and radiological similarities between interstitial lung disease–anti–myeloperoxidase and idiopathic pulmonary fibrosis Enrico Colombo1, Jessica Gozzi2, Paolo Francia3, Giulia Cervi2, Marilena Frigato1, Martina Garuti2, Francesca Bartoli1, Irene Gavioli1, Caterina Cerbone2, Massimiliano Beccaria2, Maria Teresa Costantino1 | 1SC Allergologia, Immunologia Clinica e Reumatologia, ASST Mantova; 2SC Pneumologia, ASST Mantova; 3SC Radiologia, ASST Mantova, Italy
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PO:36:242 | Bilateral central retinal artery occlusion as the first manifestation of eosinophilic granulomatosis with polyangiitis during benralizumab therapy Benedetta Fazzi1, Elena Treppo1, Lucia Finocchio2, Maria Pillon1, Luca Quartuccio1 | 1Clinica di Reumatologia, Dipartimento di Medicina, Presidio Ospedaliero Universitario Santa Maria della Misericordia, Udine; 2SOC Oculistica, Presidio Ospedaliero Universitario Santa Maria della Misericordia, ASUFC, Udine, Italy
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CO:12:2 | Circulating cell signatures of disease activity in ANCA-associated vasculitis using automated hematologic profiling analysis with Sysmex XN-9000®: preliminary results from a monocentric cohort Federica Davanzo1, Luca Iorio1, Veronica Davanzo2, Michela Pelloso2, Eleonora Fiorin1, Roberta Prevedello1, Francesca Tosato2, Martina Montagnana3, Roberto Padoan1, Andrea Doria1 | 1Rheumatology Unit, Department of Medicine DIMED, University of Padua Padova, Italy; 2Laboratory Medicine Unit, Biomedical Sciences Department-DSB, University of Padua Padova, Italy; 3Department of Medicine DIMED, University of Padua Padova, Italy
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S02:5 | Combined anti-IL-5/IL-5r and dupilumab therapy in eosinophilic granulomatosis with polyangiitis: a European retrospective study Miriam Guerini1, Pavel Novikov2, Roberto Padoan3, Georgina Espigol Frigolé4, Jan Willem Cohen Tervaert5, Vincent Grobost6, Laurent Guilleminault7, Jan Walter Schroeder8, Bernhard Hellmich9, Joana Martins Martinho10, Camillo Ribi11, Matthieu Groh12, Benjamin Terrier13. | 1IRCCS Policlinico S. Matteo, University of Pavia, Pavia, Italy; 2Sechenov University, Moscow, Russia; 3University of Padova, Padova, Italy; 4Hospital Clinic, University of Barcelona, Barcelona, Spain; 5University of Alberta, Edmonton, Canada; 6CHU Estaing Clermont-Ferrand France; 7Toulouse University Toulouse France; 8ASST Grande Ospedale Metropolitano Niguarda, Milano, Italy; 9Medius Kliniken Kirchheim-Teck Germany; 10ULS Santa Maria, Lisbon, Portugal; 11Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland; 12Hopital Foch, Suresnes, France; 13Service de Medecine interne, Hopital Cochin, AP-HP, Paris, France.
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PO:36:250 | Eosinophilic granulomatosis with polyangiitis associated to Alpha-1 Antitrypsin Deficiency: a land still unexplored Maria Grazia Malandra1, Vacchi Caterina1, Santoro Filippo1, Cassone Giulia1, Martina Orlandi1, Stefania Cerri1, Dilia Giuggioli1 | 1Università di Modena - Reggio Emilia, S.C. Reumatologia Azienda Ospedaliera Universitaria Policlinico di Modena Modena, Italy; 2S.C. Reumatologia Azienda Ospedaliera Universitaria Policlinico di Modena Modena, Italy; 3Università di Modena e Reggio Emilia, S.C. Reumatologia Azienda Ospedaliera Universitaria Policlinico di Modena Modena, Italy; 4S.C. Reumatologia Azienda Ospedaliera Universitaria Policlinico di Modena Modena, Italy; 5Università di Modena e Reggio Emilia, S.C. Reumatologia Azienda Ospedaliera Universitaria Policlinico di Modena Modena, Italy; 6Università di Modena e Reggio Emilia, S.C. Reumatologia Azienda Ospedaliera Universitaria Policlinico di Modena Modena, Italy; 7Università di Modena e Reggio Emilia, S.C. Reumatologia Azienda Ospedaliera Universitaria Policlinico di Modena Modena, Italy
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PO:35:220 | IgG anti-pentraxin 3 autoantibodies distinguish eosinophilic granulomatosis with polyangiitis from severe eosinophilic asthma and chronic rhinosinusitis with nasal polyps Eleonora Fiorin1, Anna Ghirardello1, Federica Davanzo1, Luca Iorio1, Marta Codirenzi1, Roberta Prevedello1, Roberto Padoan1, Andrea Doria1. | 1Università di Padova, Dipartimento di Medicina DIMED, UOC di Reumatologia, Padova, Italy.
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PO:11:172 | Not all vasculitis look the same: a difficult diagnosis Marta Arese1|2, Miriam Perino1|2, Sofia Aliprandi1|2, Antonella Murgo2, Maria Gerosa1|2, Roberto Felice Caporali1|2 | 1UOC Reumatologia AOR San Carlo, Potenza; 2Reumatologia Clinica, ASST Gaetano Pini-CTO, Milano, Italy
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PO:36:251 | Rheumatoid factor predicts vasculitis relapse in eosinophilic granulomatosis with polyangiitis: a machine learning approach Luca Iorio1, Federica Davanzo1, Giulia Lorenzoni2, Eleonora Fiorin1, Marta Codirenzi1, Roberta Prevedello1, Debora Campaniello1, Dario Gregori2, Roberto Padoan1, Andrea Doria1. | 1Rheumatology Unit, DIMED, University of Padova, Padova, Italy; 2Unit of Biostatistics, Epidemiology and Public Health, DCTV, University of Padova, Padova, Italy.
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PO:35:226 | Red flags raising suspicion of Eosinophilic Granulomatosis with Polyangiitis (EGPA): results from the European EGPAware Delphi study Gabriele Brembilla1, Bernhard Hellmich2|3, Apostolos Bossios4|5, Chistian Domingo-Ribas6|7, Giacomo Emmi8, Cristina Ponte9|10, Maria Roser Solans-Laque11, Íñigo Jesus Rúa-Figueroa12, Augusto Vaglio13, Dimitrios Vassilopoulos14, Konstantina Kallinikou15, Benjamin Terrier16 | 1GSK Verona, Italy; 2Medius Klinik Kirchheim Kirchheim unter Teck Germany; 3Teaching Hospital of the University of Tübingen Tübingen Germany; 4Karolinska University Hospital Stockholm, Sweden; 5Karolinska Institutet Solna, Sweden; 6Parc Taulí University Hospital. Parc Taulí Research and Innovation Institute I3PT-CERCA Barcelona Spain; 7Department of Medicine, Universitat Autònoma de Barcelona UAB Barcelona Spain; 8University of Trieste, UNITS, Trieste, Italy; 9Santa Maria Hospital Lisbon, Portugal; 10Lisbon Academic Medical Center Lisbon, Portugal; 11Vall d'Hebron University Hospital Barcelona Spain; 12Gran Canaria Doctor Negrín Hospital Las Palmas de Gran Canaria Spain; 13University of Florence Florence, Italy; 14National and Kapodistrian University of Athens School of Medicine Athens, Greece; 15GSK Athens, Greece; 16Cochin Hospital Paris, France
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PO:37:270 | Efficacy of iloprost as a therapy for skin ulcers in cryofibrinogenemia and cryoglobulinemia: a complex case in a fragile patient Luca Keller Sarmiento1, Amelia Spinella2, Marco De Pinto2, Giorgia Roveta1, Dilia Giuggioli1|2. | 1Università degli Studi di Modena e Reggio Emilia, Modena, Italy; 2Unità di Reumatologia del Policlinico di Modena, Modena, Italy.
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PO:11:162 | DRESS syndrome: a case treated with mepolizumab Alessandro Belotti Masserini1, Stefania Bertocchi1, Eleonora Bruschi1, Silvia Breda1, Valeria Rossi1, Elide Lupi1, Tania Ubiali1, Fabrizio Angeli1, Massimiliano Limonta1 | 1ASST Papa Giovanni XXIII, Bergamo, Italy
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