Case Reports
Vol. 65 No. 3 (2013)
https://doi.org/10.4081/reumatismo.2013.131

A case of propylthiouracil-induced antineutrophilic cytoplasmic antibody-positive vasculitis successfully treated with radioactive iodine

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Received: 3 August 2012
Accepted: 11 June 2013
Published: 24 July 2013
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Propylthiouracil, Antineutrophilic cytoplasmic antibody (ANCA), Radioactive iodine.

Authors

C. Bes
cemalbes@hotmail.com
Department of Rheumatology, Bakırköy Dr. Sadi Konuk Training and Research Hospital, Türkiye.
O. Dikbaş
Department of Endocrinology and Metabolism, Faculty of Medicine, Abant Izzet Baysal University, Türkiye.
E. Keskin
Department of Internal Medicine, Bakırköy Dr. Sadi Konuk Training and Research Hospital, Türkiye.
Ö. Kaptanoğulları
Department of Nephrology, Bakırköy Dr. Sadi Konuk Training and Research Hospital, Türkiye.
M. Soy
Department of Rheumatology, Hisar Intercontinental Hospital, Türkiye.
Antineutrophilic cytoplasmic antibody (ANCA) associated vasculitis is one of the rare complications of propylthiouracil treatment. Having a variable clinical spectrum, it may be presented with both skin limited vasculitis and life-threatening systemic vasculitis. In this study, we present a case that developed ANCA-positive vasculitis with skin and kidney involvement (hematuria and proteinuria) six months after propylthiouracil treatment was initiated for toxic nodular goiter. Proteinuria recovered dramatically subsequent to radioactive iodine treatment following ceasing the drug.

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1.
A case of propylthiouracil-induced antineutrophilic cytoplasmic antibody-positive vasculitis successfully treated with radioactive iodine. Reumatismo [Internet]. 2013 Jul. 24 [cited 2026 Oct. 2];65(3):131-3. Available from: https://www.reumatismo.org/reuma/article/view/reumatismo.2013.131

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