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• 

  Short story of antirheumatic therapy.VIII. The immunodepressants

  G. Pasero, P. Marson

  44-54

  19-03-2012

  https://doi.org/10.4081/reumatismo.2012.44

  1728

  PDF: 1534
• 

  Real-world experiences of folic acid supplementation (5 versus 30 mg/week) with methotrexate in rheumatoid arthritis patients: a comparison study

  K.T. Koh, C.L. Teh, C.K. Cheah, G.R. Ling, M.C. Yong, H.C. Hong, S.C. Gun

  90-96

  09-09-2016

  https://doi.org/10.4081/reumatismo.2016.872

  2811

  PDF: 1498
• 

  Systematic review of 2008-2012 literature and update of recommendations for the use of methotrexate in rheumatic diseases, with a focus on rheumatoid arthritis

  M. Todoerti, W. Maglione, E. Bernero, A. Bortoluzzi, M. Colaci, E. Galuppi, S. Paolino, R. Talarico, M. Cutolo, C. Ferri, F. Trotta, S. Bombardieri, C.M. Montecucco, L. Sinigaglia

  207-218

  18-12-2013

  https://doi.org/10.4081/reumatismo.2013.207

  4856

  PDF: 2692
• 

  The impact on disability of initial treatment with methotrexate in patients with rheumatoid arthritis: results from the MARI study

  M. Manara, L. Arcarese, G. Bianchi, V. Corbelli, O. Epis, R. Laurenti, A. Migliore, M. Muratore, A. Roncaglione, M. Rossini, M. Savo, L. Sinigaglia

  188-194

  31-12-2016

  https://doi.org/10.4081/reumatismo.2016.903

  2160

  PDF: 1033

• Biologic therapy with anti-TNFa in rheumathoid atrhritis

  G. Ferraccioli

  17-21

  https://doi.org/10.4081/reumatismo.2005.4s.17

  859

  PDF: 734

• Methotrexate in the treatment of peripheral arthritis in ulcerative colitis

  R. Peluso, M. Atteno, S. Iervolino, V. Bruner, F. Caso, L. Costa, M. Raimodo, M. Lofrano, F. Manguso, R. Scarpa

  15-20

  https://doi.org/10.4081/reumatismo.2009.15

  1421

  PDF: 1036
• 

  Update on treatment of polymyalgia rheumatica

  D. Camellino, C. Dejaco

  59-66

  27-03-2018

  https://doi.org/10.4081/reumatismo.2018.1062

  6208

  PDF: 3526
• 

  Possible relationship between certolizumab pegol and arrhythmias: report of two cases

  R. Talotta, F. Atzeni, A. Batticciotto, D. Ventura, P. Sarzi-Puttini

  104-108

  09-09-2016

  https://doi.org/10.4081/reumatismo.2016.869

  1906

  PDF: 1098

• CONVENTIONAL THERAPIES FOR PSORIASIS

  A. Rebora

  77-80

  https://doi.org/10.4081/reumatismo.2007.1s.77

  1002

  PDF: 972
• 

  Granulomatosis with polyangiitis in Tunisia

  I. Ben Ghorbel, N. Belfeki, N. Baouendi, T. Ben Salem, M.H. Houman

  23-29

  22-05-2017

  https://doi.org/10.4081/reumatismo.2017.935

  1866

  PDF: 836

• PO:08:124 | An exploratory analysis of risk factors for methotrexate-associated osteopathy: a retrospective study Federico Aldegheri¹, Francesca Ruzzon¹, Matteo Appoloni¹, Maurizio Rossini¹, Giovanni Adami¹, Davide Gatti¹, Ombretta Viapiana¹, Angelo Fassio¹ | ¹Università di Verona, Italy

  Società Italiana di Reumatologia

  18-03-2026

  https://doi.org/10.4081/reumatismo.2025.2308

  23

• Safety of methotrexate in rheumatoid arthritis: a retrospective cohort study in clinical practice

  G. La Montagna, R. Tirri, R. Vitiello, D. Malesci, R. Buono, G. Mennillo, G. Valentini

  261-267

  https://doi.org/10.4081/reumatismo.2006.261

  1396

  PDF: 784
• 

  A false occult hepatitis B virus infection developed in a patient with psoriatic arthritis under infliximab and methotrexate therapy

  A. Notarnicola, F. Iannone, G. Lopalco, M. Covelli, G. Lapadula

  298-301

  17-03-2014

  https://doi.org/10.4081/reumatismo.2013.727

  2586

  PDF: 1170

• Methylenetetrahydrofolate reductase polymorphisms in methotrexate treatment of rheumatoid arthritis patients. Review of the literature and personal experience

  M. Taraborelli, L. Andreoli, S. Archetti, M. Ferrari, R. Cattaneo, A. Tincani

  98-106

  https://doi.org/10.4081/reumatismo.2009.98

  1331

  PDF: 1266

• PO:07:101 | Efficacy and safety of methotrexate in a cohort of patients affected by early-onset rheumatoid arthritis: a monocentric real-life study Carlo Cauli¹, Martina Favretti², Giulio Dolcini², Vincenzo Ferraro¹, Cristina Iannuccelli³, Fabrizio Conti¹, Manuela Di Franco¹ | ¹UOC Reumatologia, Dipartimento di scienze cliniche internistiche anestesiologiche e cardiovascolari, Sapienza, Roma; ²Dipartimento di Medicina Molecolare, La Sapienza, Roma; ³UOC Reumatologia, AOU Policlinico Umberto I, La Sapienza, Roma, Italy

  Società Italiana di Reumatologia

  25-11-2025

  https://doi.org/10.4081/reumatismo.2025.2138

  147

• PO:10:155 | Etanercept-induced lupus in a patient with rheumatoid arthritis: diagnostic challenges and multidisciplinary therapeutic approach Camilla Riboldi^1|2, Claudia Iannone^1|2, Maria Gerosa^1|2, Roberto Felice Caporali^1|2 | ¹ASST G. Pini-CTO, U.O.C. di Clinica Reumatologica, Milano; ²Dipartimento di Scienze Cliniche e di Comunità, Università degli Studi di Milano, Italy

  Società Italiana di Reumatologia

  25-11-2025

  https://doi.org/10.4081/reumatismo.2025.2149

  136
• 

  Successful treatment of refractory adult onset Still’s disease with rituximab

  N. Belfeki, M. Smiti Khanfir, F. Said, A. Hamzaoui, T. Ben Salem, I. Ben Ghorbel, M. Lamloum, M.H. Houman

  159-162

  16-12-2016

  https://doi.org/10.4081/reumatismo.2016.888

  2867

  PDF: 1362

• Treatment of Wegener’s granulomatosis

  V. Riccieri, G. Valesini

  69-76

  https://doi.org/10.4081/reumatismo.2004.69

  1453

  PDF: 5302
• 

  Association between red cell distribution width and response to methotrexate in rheumatoid arthritis

  M. Bellan, D. Soddu, E. Zecca, A. Croce, R. Bonometti, R. Pedrazzoli, D. Sola, C. Rigamonti, L.M. Castello, G.C. Avanzi, M. Pirisi, P.P. Sainaghi

  16-20

  10-04-2020

  https://doi.org/10.4081/reumatismo.2020.1243

  2034

  PDF: 877
• 

  A short history of anti-rheumatic therapy - VI. Rheumatoid arthritis drugs

  G. Pasero, P. Marson

  111-123

  https://doi.org/10.4081/reumatismo.2011.111

  2599

  PDF: 1927

• PO:18:271 | Managing concomitant sle and psoriasis: the role of anifrolumab in a clinical case Angela Carenza¹, Liliana Dinoia², Sergio De Gioia², Federica Gatti¹, Teresa Caferri¹, Lucia Cristiana Colaprico¹, Angelica Napoletano¹, Giuseppe Lopalco¹, Florenzo Iannone¹. | ¹Rheumatology Unit, University of Bari, Department of Precision and Regenerative Medicine, Jonian area ^DiMePRe-J, Bari, Italy; ²Azienda Sanitaria Locale di Taranto, presidio ospedaliero SS. Annunziata, Unità Operativa di Reumatologia, Taranto, Italy.

  Società Italiana di Reumatologia

  25-11-2025

  https://doi.org/10.4081/reumatismo.2025.2047

  149

• PO:31:173 | Methotrexate monotherapy in early systemic sclerosis: a real-life monocentric Italian experience Claudia Iannone^1|2, Ilaria Magi^1|2, Antonina Minniti², Giuseppe Armentaro², Silvia Cavalli^1|2, Manuel Sette^1|2, Laura Giudice^1|2, Maria Rosa Pellico^1|2, Cristina Bochicchio^1|2, Roberto Felice Caporali^1|2, Nicoletta Del Papa^1|2. | ¹Dipartimento di Scienze Cliniche e di Comunità, Università degli Studi di Milano, Milano, Italy; ²Dipartimento di Reumatologia e Scienze Mediche, ASST G. Pini-CTO, Milano, Italy.

  Società Italiana di Reumatologia

  25-11-2025

  https://doi.org/10.4081/reumatismo.2025.2074

  132

• PO:37:267 | Mimickers of polyarteritis nodosa: a case of segmental arteriolar mediolysis Filippo Santoro¹, Caterina Vacchi², Giulia Cassone², Maria Grazia Malandra¹, Dilia Giuggioli^1|2 | ¹UOSD Reumatologia, Ospedale San Camillo De Lellis, Rieti; ²UOC Igiene e Sanità Pubblica, ASL Rieti; ³Direzione Sanitaria, ASL Rieti, Italy

  Società Italiana di Reumatologia

  25-11-2025

  https://doi.org/10.4081/reumatismo.2025.2221

  160
• 

  The role of klotho in systemic sclerosis

  R. Talotta, S. Bongiovanni, T. Letizia, F. Rigamonti, F. Atzeni, M. Benucci, T. Vago, P. Sarzi-Puttini

  156-163

  21-12-2017

  https://doi.org/10.4081/reumatismo.2017.987

  2004

  PDF: 1093

• Italian consensus on the recommendations about the use of methotrexate for the treatment of rheumatic diseases with a focus on rheumatoid arthritis: results from the “3E initiative”

  F. De Leonardis, S. Aliverini, E. Bonacci, A.M. Buono, S. Bombardieri, G.F. Ferraccioli, C. Montecucco, L. Sinigaglia, F. Trotta, G. Valentini

  34-45

  https://doi.org/10.4081/reumatismo.2010.34

  2299

  PDF: 2385

• PO:05:069 | Risankizumab efficacy in peripheral and axial involvement: monocentric experience Roberta Foti¹, Ylenia Dal Bosco¹, Giorgio Amato¹, Elisa Visalli¹, Francesco De Lucia¹, Gabriella Paolí¹, Rosario Foti¹. | ¹UOSD Reumatologia AOU Policlinico G. Rodolico-S. Marco, Catania, Italy.

  Società Italiana di Reumatologia

  25-11-2025

  https://doi.org/10.4081/reumatismo.2025.2012

  133
• 

  Jaccoud’s arthropathy, an unusual manifestation of idiopathic retroperitoneal fibrosis: rapid improvement of symptoms after tocilizumab treatment

  M. Benucci, A. Damiani, F. Li Gobbi, V. Grossi, M. Infantino, A. Arena, M. Manfredi

  88-91

  03-08-2017

  https://doi.org/10.4081/reumatismo.2017.968

  2380

  PDF: 1113

• Correlation between radiographic, echographic and MRI changes and rheumatoid arthritis progression

  M.A. Cimmino, M. Parodi, E. Silvestri, G. Garlaschi

  28-40

  https://doi.org/10.4081/reumatismo.2004.1s.28

  1133

  PDF: 3005

• PO:19:283 | Hospitalization profile and complications in patients with adult-onset Still’s disease: results from a retrospective study of 74 cases Chiara Calabrese¹, Alessandro Tomelleri^1|2, Corrado Campochiaro^1|2, Nicola Farina², Elena Baldissera², Marco Matucci-Cerinic^1|2, Lorenzo Dagna^1|2 | ¹Libera Università Vita-Salute San Raffaele, Milano; ²Unità di Immunologia, Allergologia e malattie rare, IRCCS San Raffaele, Milano, Italy

  Società Italiana di Reumatologia

  25-11-2025

  https://doi.org/10.4081/reumatismo.2025.2172

  130

• Case report: AREB in a patient with rheumatoid arthritis treated with methotrexate and infliximab

  Giuseppe D'Alessandro, Maria Rosaria Bianco, Spiridon Politis, Celestino Ferrandina, Giuseppe Rossi, Emanuele Altomare

  59-61

  https://doi.org/10.4081/reumatismo.2006.59

  1033

  PDF: 967

• The treatment of recurrent uveitis with TNFα inhibitors

  P.C.F. Falappone, F. Iannone, C. Scioscia, V. Grattagliano, M. Covelli, G. Lapadula

  185-189

  https://doi.org/10.4081/reumatismo.2004.185

  1907

  PDF: 2513
• 

  Psoriatic arthritis: treatment strategies using anti-inflammatory drugs and classical DMARDs

  E. Lubrano, R. Scarpa

  107-112

  05-06-2012

  https://doi.org/10.4081/reumatismo.2012.107

  1545

  PDF: 1365

• PO:18:264 | Anifrolumab in Systemic Lupus Erythematosus: Bridging Clinical Trial Data with Real-World Evidence Giulia Cassone², Filippo Santoro¹, Caterina Vacchi², Dilia Giuggioli², Chiara Cabassi¹ | ¹UOC Reumatologia, AOU Policlinico di Modena, Università degli studi di Modena e Reggio Emilia Modena e Reggio Emilia, Italy; ²UOC Reumatologia, AOU Policlinico di Modena Modena, Italy

  Società Italiana di Reumatologia

  18-03-2026

  https://doi.org/10.4081/reumatismo.2025.2337

  55

• Long-term survival of methotrexate in psoriatic arthritis

  M. Ricci, G. De Marco, F. Desiati, D. Mazzocchi, L. Rotunno, N. Battafarano, A. Marchesoni

  125-131

  https://doi.org/10.4081/reumatismo.2009.125

  1443

  PDF: 975

• PO:17:253 | Unveiling the gap: a multicenter study on factors driving patient-physician discrepancies in assessing disease activity in systemic lupus erythematosus Giorgia Ingrid Gozzoli¹, Micaela Fredi¹, Federica Bonaso¹, Silvia Ebe Lucia Della Pina¹, Claudia Barison¹, Irene Lorenzini⁴, Raffaele Pericotti⁴, Anna Mattiuzzo⁴, Marcelo Neto², Sofia Azevedo³, Cláudia Oliveira³, Cesare Tomasi⁴, Luís Sousa Inês², Franco Franceschini¹. | ¹Rheumatology and Clinical Immunology Unit, ASST Spedali Civili of Brescia, Brescia, Italy; ²Rheumatology Department, Centro Hospitalar Universitário de Coimbra - ULS Coimbra, Coimbra, Portugal; ³Rheumatology  Department, ULS Aveiro, Aveiro, Portugal; ⁴Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.

  Società Italiana di Reumatologia

  25-11-2025

  https://doi.org/10.4081/reumatismo.2025.2046

  140

• Long-term evaluation of infliximab in the treatment of persistently active juvenile idiopathic arthritis refractory to conventional therapy

  G. De Marco, V. Gerloni, I. Pontikaki, A. Lurati, B. Teruzzi, A. Salmaso, E. Valcamonica, M. Gattinara, F. Fantini

  50-56

  https://doi.org/10.4081/reumatismo.2007.50

  1272

  PDF: 875

• PO:07:111 | Worsening of patient-reported outcomes is an early predictor of disease flare in patients with rheumatoid arthritis in course of treatment with conventional synthetic disease modifying anti-rheumatic drugs Ludovico De Stefano^1|2, Federica Sabatelli^1|2, Clelia Zampaglione^1|2, Blerina Xoxi², Antonio Manzo^1|2, Carlomaurizio Montecucco^1|2, Serena Bugatti^1|2. | ¹Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy; ²Division of Rheumatology, IRCCS Policlinico San Matteo Foundation, Pavia, Italy.

  Società Italiana di Reumatologia

  25-11-2025

  https://doi.org/10.4081/reumatismo.2025.2022

  136

• PO:17:259 | Anifrolumab: a new management of SLE Giorgia Montozzi¹, Chiara Cocco¹, Ramona Santangeli¹, Lucia Gamba¹, Paola Fioretti¹, Letizia Curina¹, Chiara Guidoni¹, Edoardo Cipolletta³, Gianluca Moroncini² | ¹Scuola di Specializzazione in Medicina Interna, Università Politecnica delle Marche Ancona, Italy; ²Department of Clinical and Molecular Sciences, Università Politecnica delle Marche Ancona, Italy; ³Rheumatology Unit, Department of Clinical and Molecular Sciences , Università Politecnica delle Marche Ancona, Italy

  Società Italiana di Reumatologia

  18-03-2026

  https://doi.org/10.4081/reumatismo.2025.2336

  38

• Switching between TNFα antagonists in rheumatoid arthritis: personal experience and review of the literature

  R. Scrivo, F. Conti, F.R. Spinelli, S. Truglia, L. Magrini, M. Di Franco, F. Ceccarelli, G. Valesini

  107-117

  https://doi.org/10.4081/reumatismo.2009.107

  2056

  PDF: 1238

• PO:17:252 | The choice between belimumab and anifrolumab: analysis of a monocentric cohort Fabio Congiu¹, Elisabetta Chessa², Giulia Rizzo¹, Elena Ragusa¹, Marta Paola Pireddu¹, Alessandra Oliva¹, Marianna Salis¹, Mattia Congia², Maria Maddalena Angioni¹, Micaela Rita Naitza¹, Alberto Floris², Alberto Cauli^1|2, Matteo Piga^1|2 | ¹AOU e Università degli studi di Cagliari; ²SC Reumatologia PO Duilio Casula, Cagliari, Italy

  Società Italiana di Reumatologia

  25-11-2025

  https://doi.org/10.4081/reumatismo.2025.2167

  144

• Psoriatic arthritis: epidemiological and clinical aspects in a cohort of 1.306 italian patients

  C. Cervini, G. Leardini, A. Mathieu, L. Punzi, R. Scarpa

  283-290

  https://doi.org/10.4081/reumatismo.2005.283

  1939

  PDF: 2124

• PO:30:153 | Long-term outcomes of JIA-associated uveitis: a systematic review and meta-analysis Laura Scagnellato¹, Giacomo Cozzi¹, Matteo Molfese¹, Mariagrazia Lorenzin¹, Jamie Alexander King¹, Gianluca Poncina¹, Stefano Rizzetto¹, Roberta Ramonda¹ | ¹UOC Reumatologia, Dipartimento di Medicina dei Sistemi DIMED, Ospedale Università di Padova, Italy

  Società Italiana di Reumatologia

  18-03-2026

  https://doi.org/10.4081/reumatismo.2025.2363

  37

• Retention rate of abatacept in rheumatoid arthritis patients in a real-life setting: results from a monocentric cohort

  E. Molteni, C. Pirone, F. Ceccarelli, C. Castellani, C. Alessandri, M. Di Franco, V. Riccieri, F.R. Spinelli, R. Priori, R. Scrivo, F. Conti

  24-06-2024

  https://doi.org/10.4081/reumatismo.2024.1608

  2032

  PDF: 698

• Anakinra, a recombinant human IL-1 receptor antagonist, in clinical practice. Outcome in 60 patients with severe rheumatoid arthritis

  C. Botsios, P. Sfriso, A. Furlan, P. Ostuni, M. Biscaro, U. Fiocco, S. Todesco, L. Punzi

  32-37

  https://doi.org/10.4081/reumatismo.2007.32

  1884

  PDF: 835

• PO:33:190 | Travel distance to tertiary healthcare reflects disease severity and medication access in systemic sclerosis patients: insights from the Italian systemic sclerosis progression investigation registry of the Italian Society of Rheumatology Camilla Teresa Magnanimi¹, Enrico De Lorenzis¹, Gerlando Natalello¹, Fabio Cacciapaglia², Rossella De Angelis³, Edoardo Cipolletta³, Maria Antonietta D'Agostino¹, Veronica Cudullo⁴, Giacomo De Luca⁵, Dilia Giuggioli⁶, Francesca Ingegnoli⁷, Valeria Riccieri⁸, Lorenzo Dagna⁵, Fiorenzo Iannone⁹, Clodoveo Ferri⁶, Marco Matucci Cerinic⁵, Silvia Laura Bosello¹. | ¹Division of Rheumatology and Clinical Immunology, Catholic University of the Sacred Heart, Fondazione Policlinico Univer, Roma, Italy; ²Department of Medicine and Surgery, LUM University Giuseppe De Gennaro Casamassima e Rheumatology Service Miulli Ge, Bari, Italy; ³Rheumatology Unit - Department of Clinical and Molecular Sciences, Polytechnic University of Marche, Ancona, Italy; ⁴Department of Rheumatology, Policlinico San Matteo, Pavia, Italy; ⁵Unit of Immunology, Rheumatology, Allergy and Rare Diseases ^UnIRAR, IRCCS San Raffaele Scientific Institute, Vita-Salu, Milano, Italy; ⁶Rheumatology Unit, School of Medicine, University of Modena and Reggio Emilia, Modena, Italy; ⁷Division of Clinical Rheumatology, ASST Pini, Dept. of Clinical Sciences e Community Health, Research Center for Adult a, Milano, Italy; ⁸Department of Rheumatology, La Sapienza University of Rome, Roma, Italy; ⁹Rheumatology Unit, Department of Precision and Regenerative Medicine and Ionian Area, University of Bari, Bari, Italy.

  Società Italiana di Reumatologia

  25-11-2025

  https://doi.org/10.4081/reumatismo.2025.2081

  146

• Idiopathic hypereosinophilic syndrome associated with rheumatoid arthritis A case report

  D. Bonanno, R. Fedele, P. Minciullo, P. Quattrocchi, B. Ferlazzo

  181-183

  https://doi.org/10.4081/reumatismo.2003.181

  2140

• PO:10:150 | A case of pulmonary hypertension in Whipple's disease Alba Chiara Pozzi^1|2, Giulia Fontana^1|2, Francesca Crisafulli^1|2, Guarino Daniele³, Monica Salvi³, Massimiliano Palazzini³, Francesco Biagi^4|5, Ilaria Cavazzana^1|2, Franco Franceschini^1|2, Micol Frassi¹. | ¹Rheumatology and Clinical Immunology Unit ERN-ReCONNECT, ASST Spedali Civili, Brescia, Italy; ²Department of Clinical Experimental Sciences, University of Brescia, Brescia; ³IRCCS Azienda Ospedaliero-Universitaria di Bologna, University of Bologna, Cardiology Unit, DIMEC, Bologna; ⁴University of Pavia, Department of Internal Medicine and Therapeutics, Pavia; ⁵Istituti Clinici Scientifici Maugeri IRCCS, Gastroenterology Unit of Pavia Institute, Pavia, Italy.

  Società Italiana di Reumatologia

  25-11-2025

  https://doi.org/10.4081/reumatismo.2025.2026

  130

• PO:08:119 | Infusional Advantage: Rituximab’s Role in Enhancing Adherence in Multimorbid Rheumatoid Arthritis Marco Capodiferro¹, Daniele Domanico¹, Angelica Napoletano¹, Giulia Righetti², Patrizia Suppressa², Vincenzo Venerito¹, Giuseppe Lopalco¹, Florenzo Iannone¹, Fabio Cacciapaglia^1|2 | ¹Rheumatology Unit, Department of Precision and Regenerative Medicine and Jonian Area DiMePRe-J University of Bari, Italy; ²Department of Medicine and Surgery, Miulli General Hospital Acquaviva delle Fonti - LUM University Casamassima Bari Acquaviva delle Fonti, Bari, Italy

  Società Italiana di Reumatologia

  18-03-2026

  https://doi.org/10.4081/reumatismo.2025.2307

  13

• PO:37:260 | Mepolizumab in the treatment of patients with eosinophilic granulomatosis with polyangiitis: real-life experience from a single-center cohort Eleonora Bruschi¹, Fabrizio Angeli¹, Alessandro Belotti Masserini¹, Stefania Bertocchi¹, Silvia Breda¹, Elide Lupi¹, Valeria Rossi¹, Tania Ubiali¹, Massimiliano Limonta¹ | ¹ASST Papa Giovanni XXIII Bergamo Italy

  Società Italiana di Reumatologia

  25-11-2025

  https://doi.org/10.4081/reumatismo.2025.2220

  139

• IL-1Ra (recombinant human IL-1 receptor antagonist) in the treatment of rheumatoid arthritis: the efficacy

  U. Fiocco, M. Vezzù, L. Cozzi, S. Todesco

  62-73

  https://doi.org/10.4081/reumatismo.2004.1s.62

  1483

  PDF: 2000