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PO:35:226 | Red flags raising suspicion of Eosinophilic Granulomatosis with Polyangiitis (EGPA): results from the European EGPAware Delphi study Gabriele Brembilla1, Bernhard Hellmich2|3, Apostolos Bossios4|5, Chistian Domingo-Ribas6|7, Giacomo Emmi8, Cristina Ponte9|10, Maria Roser Solans-Laque11, Íñigo Jesus Rúa-Figueroa12, Augusto Vaglio13, Dimitrios Vassilopoulos14, Konstantina Kallinikou15, Benjamin Terrier16 | 1GSK Verona, Italy; 2Medius Klinik Kirchheim Kirchheim unter Teck Germany; 3Teaching Hospital of the University of Tübingen Tübingen Germany; 4Karolinska University Hospital Stockholm, Sweden; 5Karolinska Institutet Solna, Sweden; 6Parc Taulí University Hospital. Parc Taulí Research and Innovation Institute I3PT-CERCA Barcelona Spain; 7Department of Medicine, Universitat Autònoma de Barcelona UAB Barcelona Spain; 8University of Trieste, UNITS, Trieste, Italy; 9Santa Maria Hospital Lisbon, Portugal; 10Lisbon Academic Medical Center Lisbon, Portugal; 11Vall d'Hebron University Hospital Barcelona Spain; 12Gran Canaria Doctor Negrín Hospital Las Palmas de Gran Canaria Spain; 13University of Florence Florence, Italy; 14National and Kapodistrian University of Athens School of Medicine Athens, Greece; 15GSK Athens, Greece; 16Cochin Hospital Paris, France
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PO:06:094 | Exploring the relationship between inflammation and collagen deposition in synovial tissue and clinical outcomes in active arthritis: insights from a monocentric pilot study Dario Bruno1, Barbara Tolusso1, Daniela Renna1, Mohamed Hegazi2, Fabio Pasqualini2, Marta Caprioli1, Giacomo Maria Guidelli1, Tommaso Hubert3, Nicoletta Luciano1|3, Marzia Monferini3, Natasa Isailovic3, Fabio Grizzi2|3, Salvatorelorenzo Renne3, Costantino Pitzalis1|3|4, Elisa Gremese1|3. | 1Rheumatology and Clinical Immunology, IRCCS Humanitas Research Hospital, Rozzano (MI); 2Department of Immunology and Inflammation, IRCCS Humanitas Research Hospital, Milano; 3Department of Biomedical Sciences, Humanitas University, Rozzano (MI), Italy; 4Centre for Experimental Medicine and Rheumatology, Queen Mary University of London, London, UK
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PO:36:244 | Early diagnosis in eosinophilic granulomatosis with polyangiitis: a multidisciplinary approach Federico Giuseppe Lazzaro1, Elena Chiaradia2, Chiara Lombardi2, Flavia Leone1, Massimo Nucci2, Roberta Masnata2, Flora Niedda2, Maria Rita Gigante1, Pietro Rubortone1, Silvia Laura Bosello1|2, Maria Antonietta D'Agostino1|2, Augusta Ortolan1|2. | 1Divisione di Reumatologia ed Immunologia Clinica, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy; 2Università Cattolica del Sacro Cuore, Roma, Italy.
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CO:08:1 | Aquaporin-4 downregulation in dysphagic idiopathic inflammatory myopathies: association with Type 2 fiber damage and inflammation Marco Fornaro1, Margherita Giannini2, Dario D'Abbicco3, Maria Luisa Fiorella4, Antonio Frigeri5, Francesco Girolamo6, Florenzo Iannone1. | 1Unit of Rheumatology, Department of Precision and Regenerative Medicine and Ionian Area, Bari, Italy; 2Physiologie et Explorations Fonctionnelles Musculaires, University Hospital of Strasbourg, Strasburgo, France; 3Institute of General Surgery G Marinaccio, Department of Precision and Regenerative Medicine and Ionian Area, Bari; 4Unit of Otolaryngology, Department of Translational Biomedicine and Neuroscience DiBraiN, Bari; 5Unit of Human Physiology, Department of Translational Biomedicine and Neuroscience DiBraiN, Bari; 6Unit of Human Anatomy and Histology, Department of Translational Biomedicine and Neuroscience DiBraiN, Bari, Italy
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PO:20:003 | Romosozumab effect on neutrophil-to-lymphocyte ratio in post-menopausal women at high risk of fracture Giorgia Scagliosi1, Mariana Diaz Lopez1, Martina Teoni1, Francesco Pollastri1, Anna Piccinelli1, Camilla Benini1, Valeria Messina1, Emma Pasetto1, Davide Gatti1, Ombretta Viapiana1, Maurizio Rossini1, Giovanni Adami1. | 1Università di Verona, Dipartimento di Medicina, Verona, Italy; 2Università di Verona, Dipartimento di Medicina, Verona, Italy; 3Università di Verona, Dipartimento di Medicina, Verona, Italy; 4Università di Verona, Dipartimento di Medicina, Verona, Italy; 5Università di Verona, Dipartimento di Medicina, Verona, Italy; 6Università di Verona, Dipartimento di Medicina, Verona, Italy; 7Università di Verona, Dipartimento di Medicina, Verona, Italy; 8Università di Verona, Dipartimento di Medicina, Verona, Italy; 9Università di Verona, Dipartimento di Medicina, Verona, Italy; 10Università di Verona, Dipartimento di Medicina, Verona, Italy; 11Università di Verona, Dipartimento di Medicina, Verona, Italy; 12Università di Verona, Dipartimento di Medicina, Verona, Italy.
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PO:31:167 | Increased M2 pro-fibrotic marker expression in circulating monocytes and cultured monocyte-derived macrophages in systemic sclerosis patients with progressive interstitial lung disease Vanessa Smith1|2, Stefano Soldano3, Rosanna Campitiello3|5, Emanuele Gotelli3|4, Paola Montagna3, Elvis Hysa3|5, Tamara Vojinovic3|4, Carmen Pizzorni3|4, Sabrina Paolino3|4, Alberto Sulli3|4, Maurizio Cutolo3|4. | 1Department of Internal Medicine and Department of Rheumatology, Ghent University Hospital, Ghent, Belgium; 2Unit for Molecular Immunology and Inflammation, VIB Inflammation Research Centre, Ghent, Belgium; 3Laboratory of Experimental Rheumatology and Academic Division of Clinical Rheumatology, Department of Internal Medicine, Genova, Italy; 4IRCCS Ospedale Policlinico San Martino, Genova, Italy; 5Department of Experimental Medicine DIMES, University of Genova, Genova, Italy.
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PO:07:098 | Reasons for treatment failure and their synovial correlate among patients with difficult-to-treat rheumatoid arthritis Alessandro Giollo1, Mariangela Salvato1, Francesca Frizzera1, Kiren Khalid1, Lorenzo Di Luozzo1, Carlo Garaffoni2, Maria Capita2, Marianna Tamussin2, Giovanni Lanza2, Marny Fedrigo3, Annalisa Angelini3, Roberta Ramonda1, Ettore Silvagni2, Andrea Doria1 | 1UOC Reumatologia Padova, Italy; 2UOC Reumatologia Ferrara, Italy; 3UOC Patologia cardiovascolare Padova, Italy; 4UOC Anatomia Patologica Ferrara, Italy
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PO:22:038 | Recurrent Pneumonias and Persistent Inflammation in VEXAS Syndrome: The Role of BAL in Differential Diagnosis Francesco Ghellere1, Bernardo D'Onofrio1, Maria Chiara Ditto1, Salvatore Panaro1, Francesca Piccione1|2, Giacomo Tanti1, Enrico Fusaro1, Simone Parisi1 | 1SC Reumatologia, Città della Salute e della Scienza Torino, Italy; 2Fondazione Ricerca Molinette Torino, Italy
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PO:36:246 | Early real-world outcomes with benralizumab in eosinophilic granulomatosis with polyangiitis: a monocentric retrospective Richard Borrelli1, Stefania Nicola1, Federica Corradi1, Iuliana Badiu1, Marzia Boem1, Valentina Marmora1, Simone Negrini1, Luisa Brussino1. | 1SCDU Immunologia e Allergologia, AO Mauriziano, Dipartimento di Scienze Mediche, Università degli Studi di Torino, Torino, Italy.
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PO:33:201 | Metabolic and functional state of circulating platelets in patients with systemic sclerosis Annalisa Villa1, Simona Truglia1, Francesca Maiorca2, Annamaria Sabetta2, Ludovica Lombardi2, Silvia D'Orso2, Lucia Stefanini2, Fabrizio Conti1, Marcella Visentini2, Valeria Riccieri1 | 1Dipartimento di Scienze Cliniche, Internistiche, Anestesiologiche e Cardiovascolari, Università degli Studi di Roma La Sapienza; 2Dipartimento di Medicina Traslazionale e di Precisione, Università degli Studi di Roma La Sapienza
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From anatomy to therapy: the historical journey to cortisone
1859PDF: 34SUPPLEMENTARY MATERIAL: 97 -
PO:32:183 | Innovative use of integra dermal regeneration template on systemic sclerosis digital ulcers: a case report Elena Vanni1, Martina Orlandi1|2, Amelia Spinella2, Valentina Pinto3, Massimo Pinelli3, Dilia Giuggioli1|2 | 1Reumatologia, Università di Modena e Reggio Emilia; 2Reumatologia, Azienda Ospedaliero-Universitaria Policlinico di Modena; 3Chirurgia Plastica, Università di Modena e Reggio Emilia e Azienda Ospedaliero-Universitaria, Policlinico di Modena, Italy
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PO:10:153 | Isolated sarcoidosis of the parotid gland: a rare case of unilateral presentation Irene Carlino1, Giorgio Carlino2, Silvia Lombardo3, Luigi Gennari1 | 1Internal Medicine Unit, Department of Medicine Surgery and Neuroscience, University of Siena; 2ASL Lecce, Rheumatology Service DSS Casarano-Gallipoli-Gagliano del Capo, Gallipoli (LE); 3ASL Lecce, DSS Gagliano del Capo, Ugento (LE); Italy
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PO:13:188 | Menstrual alterations among women with rheumatoid arthritis: a comparative study across treatment modalities with focus on JAK inhibitors Angelica Napoletano1, Francesca Arezzo2, Marco Fornaro1, Giuseppe Lopalco1, Gennaro Cormio2, Vincenzo Venerito1, Florenzo Iannone1. | 1University of Bari, Rheumatology Unit Department of Precision and Regenerative Medicine, Jonica Area, Bari; 2Gynecologic Oncology, IRCCS Istituto Tumori Giovanni Paolo II, Bari, Italy.
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PO:33:195 | Evaluation of prevalence and role of anti-endothelin type a-receptor and anti-angiotensin ii type 1-receptor antibodies in a cohort of systemic sclerosis patients Clara Minerba1, Sara Ferrigno1, Antonella Grimaldi2, Noemi Aprile3, Daniela Costanza2, Laura Quarta2, Maria Rita Ricciardi2, Daniela Stasi3, Paola Conigliaro1, Alberto Bergamini1, Eugenio Quarta2, Maria Sole Chimenti1. | 1U.O.C. Reumatologia, Dipartimento di Medicina dei Sistemi, Università di, Roma, Tor Vergata, Roma, Italy; 2U.O.S.D. Reumatologia, P.O. Vito Fazzi Lecce Italy; 3U.O.C. Patologia clinica e Microbiologia, P.O. Vito Fazzi Lecce Italy.
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CO:07:5 | Enhanced fibroblast signatures in females with early rheumatoid arthritis highlights a potential basis for poorer treatment outcomes Benedetta Monosi1, James Perera2, Alessandra Nerviani2|3, Maria Sole Chimenti1, Felice Rivellese2|3, Costantino Pitzalis2|3|4. | 1Rheumatology, Allergology and Clinical Immunology, Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy; 2Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Queen Mary University of London, London, UK; 3Barts Health NHS Trust and Barts Biomedical Research Centre, National Institute for Health and Care Research, London, UK; 4Department of Biomedical Sciences Humanitas University and IRCCS Humanitas Research Hospital, Milano, Italy
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PO:37:258 | Neutrophil and eosinophil extracellular traps in eosinophilic granulomatosis with polyangiitis: phenotype-based characterization and response to mepolizumab Michele Moretti1, Francesco Ferro2, Francesco Pisani1, Elisa Ferrigno1, Gaetano La Rocca1, Federica Di Cianni3, Rosaria Talarico2, Marta Mosca1, Chiara Baldini1, Ilaria Puxeddu1. | 1University of Pisa - Department of Clinical and Experimental Medicine, Pisa, Italy; 2Azienda Ospedaliero Universitaria Pisana - Rheumatology Unit, Pisa, Italy; 3University of Siena, Siena, Italy.
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