https://doi.org/10.4081/reumatismo.2021.1431

Biclonal gammopathy of undetermined significance in a patient with systemic lupus erythematosus and antiphospholipid syndrome

Vol. 73 No. 4 (2021)
Published: February 7 2022
Biclonal gammopathy, SLE, APS, neoplastic disease, amyloidosis, infection.
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Authors

V. Bruzzese
https://orcid.org/0000-0001-7342-6350
U.O.C. Internal Medicine and Rheumatology, ASL Roma 1, Hospital S. Spirito-Nuovo Regina Margherita, Rome, Italy.
P. Scolieri
palma.scolieri@gmail.com
https://orcid.org/0000-0002-2055-7282
U.O.C. Internal Medicine and Rheumatology, ASL Roma 1, Hospital S. Spirito-Nuovo Regina Margherita, Rome, Italy.
J. Pepe
Department of Clinical, Internal, Anesthesiology and Cardiovascular Sciences, La Sapienza University, Rome, Italy.

The case of a patient suffering from systemic lupus erythematosus with associated antiphospholipid antibody syndrome is described. In this patient, on protein electrophoresis, two monoclonal immunoglobulin G λ and k peaks were seen, defining a condition of biclonal gammopathy of undetermined significance (BGUS). This condition is extremely rare, especially in chronic inflammatory rheumatic diseases. The criteria of a BGUS are defined. We also underline how this condition can be the expression of a concomitant unrecognized cancer, a possible amyloidosis or an infectious process.

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Biclonal gammopathy of undetermined significance in a patient with systemic lupus erythematosus and antiphospholipid syndrome. (2022). Reumatismo, 73(4). https://doi.org/10.4081/reumatismo.2021.1431
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