Histopathology of the synovial tissue: perspectives for biomarker development in chronic inflammatory arthritides

  • A. Manzo | antonio.manzo@unipv.it Rheumatology and Translational Immunology Research Laboratories (LaRIT), Division of Rheumatology, IRCCS Policlinico San Matteo Foundation/University of Pavia, Italy.
  • S. Bugatti Rheumatology and Translational Immunology Research Laboratories (LaRIT), Division of Rheumatology, IRCCS Policlinico San Matteo Foundation/University of Pavia, Italy.
  • R. Caporali Rheumatology and Translational Immunology Research Laboratories (LaRIT), Division of Rheumatology, IRCCS Policlinico San Matteo Foundation/University of Pavia, Italy.
  • C. Montecucco Rheumatology and Translational Immunology Research Laboratories (LaRIT), Division of Rheumatology, IRCCS Policlinico San Matteo Foundation/University of Pavia, Italy.

Abstract

The histopathological and molecular analysis of the synovial tissue has contributed to fundamental advances in our comprehension of arthritis pathogenesis and of the mechanisms of action of currently available treatments. On the other hand, its exploitation in clinical practice for diagnostic or prognostic purposes as well as for the prediction of treatment response to specific disease-modifying anti-rheumatic drugs is still limited. In this review, we present an overview of recent advances in the field of synovial tissue research with specific reference to the methods for synovial tissue collection, approaches to synovial tissue analysis and current perspectives for the exploitation of synovial tissue-derived biomarkers in chronic inflammatory arthritides.

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Published
2018-10-03
Keywords:
Synovitis, Arthritis, Histopathology.
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How to Cite
Manzo, A., Bugatti, S., Caporali, R., & Montecucco, C. (2018). Histopathology of the synovial tissue: perspectives for biomarker development in chronic inflammatory arthritides. Reumatismo, 70(3), 121-132. https://doi.org/10.4081/reumatismo.2018.1057

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