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• CO:10:1 | High-grade synovitis and histological pathotype distribution in patients with advanced osteoarthritis undergoing joint replacement: a more inflammatory disease than we thought? Jacopo Ciaffi¹, Lorenzo Bianchi¹, Luana Mancarella², Federica Pignatti², Veronica Brusi², Lucia Lisi², Simona Neri², Elisa Assirelli², Alberto Righi³, Marco Gambarotti³, Francesco Ursini¹. | ¹SSD Medicina e Reumatologia, IRCCS Istituto Ortopedico Rizzoli, Alma Mater Studiorum Università di Bologna; ²SSD Medicina e Reumatologia, IRCCS Istituto Ortopedico Rizzoli, Bologna; ³SSD di Anatomia e Istologia Patologica, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy

  Società Italiana di Reumatologia

  25-11-2025

  https://doi.org/10.4081/reumatismo.2025.1990

  146

• CO:10:3 | Clinical response to JAK inhibitors or non-TNFi-targeted biologicals according to synovial tissue characteristics in patients with difficult-to-treat rheumatoid arthritis Mariangela Salvato¹, Alessandro Giollo¹, Francesca Frizzera¹, Kiren Khalid¹, Lorenzo Di Luozzo¹, Maria Capita¹, Marianna Tamussin¹, Carlo Garaffoni², Marny Fedrigo³, Annalisa Angelini³, Ettore Silvagni², Andrea Doria¹. | ¹Rheumatology Unit, Department of Medicine - DIMED, University of Padova; ²Rheumatology Unit, Department of Medical Sciences, University of Ferrara and Azienda Ospedaliero-Universitaria S. Anna; ³Cardiovascular Pathology, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, Italy

  Società Italiana di Reumatologia

  25-11-2025

  https://doi.org/10.4081/reumatismo.2025.1992

  161

• CO:07:5 | Enhanced fibroblast signatures in females with early rheumatoid arthritis highlights a potential basis for poorer treatment outcomes Benedetta Monosi¹, James Perera², Alessandra Nerviani^2|3, Maria Sole Chimenti¹, Felice Rivellese^2|3, Costantino Pitzalis^2|3|4. | ¹Rheumatology, Allergology and Clinical Immunology, Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy; ²Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Queen Mary University of London, London, UK; ³Barts Health NHS Trust and Barts Biomedical Research Centre, National Institute for Health and Care Research, London, UK; ⁴Department of Biomedical Sciences Humanitas University and IRCCS Humanitas Research Hospital, Milano, Italy

  Società Italiana di Reumatologia

  25-11-2025

  https://doi.org/10.4081/reumatismo.2025.1980

  180

• PO:07:098 | Reasons for treatment failure and their synovial correlate among patients with difficult-to-treat rheumatoid arthritis Alessandro Giollo¹, Mariangela Salvato¹, Francesca Frizzera¹, Kiren Khalid¹, Lorenzo Di Luozzo¹, Carlo Garaffoni², Maria Capita², Marianna Tamussin², Giovanni Lanza², Marny Fedrigo³, Annalisa Angelini³, Roberta Ramonda¹, Ettore Silvagni², Andrea Doria¹ | ¹UOC Reumatologia Padova, Italy; ²UOC Reumatologia Ferrara, Italy; ³UOC Patologia cardiovascolare Padova, Italy; ⁴UOC Anatomia Patologica Ferrara, Italy

  Società Italiana di Reumatologia

  18-03-2026

  https://doi.org/10.4081/reumatismo.2025.2304

  23