https://doi.org/10.4081/reumatismo.2023.1566

Acute severe gouty arthritis secondary to isotretinoin toxicity in a young male: a case report

Vol. 75 No. 3 (2023)
Submitted: 11 February 2023
Accepted: 3 August 2023
Published: 18 September 2023
Gout, arthritis, isotretinoin toxicity, acne, adverse effects
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Authors

D.S. Meena
dsmims14@gmail.com
Department of Internal Medicine, All India Institute of Medical Sciences, Jodhpur, India.
D. Kumar
Department of Internal Medicine, All India Institute of Medical Sciences, Jodhpur, India.
G.K. Bohra
Department of Internal Medicine, All India Institute of Medical Sciences, Jodhpur, India.

Acute gouty arthritis is a recognized complication of hyperuricemia and one of the most common forms of inflammatory arthritis in adults. Drug-induced hyperuricemia is increasingly prevalent in clinical practice. Diuretics, antitubercular medications, and immunosuppressants are the common drugs associated with hyperuricemia. Oral isotretinoin is the drug of choice for different forms of severe acne and is rarely associated with hyperuricemia. We present the case of a 30-year-old male with severe acne vulgaris who was prescribed isotretinoin and later presented with acute gout. The patient developed hyperuricemia and swelling of the right first metatarsophalangeal joint within two months of isotretinoin commencement. There was a second episode of similar joint swelling three months later, parallel to the isotretinoin rechallenge. The dose of isotretinoin was reduced with the addition of febuxostat. The patient did not develop further episodes and remained symptom-free without urate-lowering therapy.

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How to Cite

Meena, D., Kumar, D., & Bohra, G. (2023). Acute severe gouty arthritis secondary to isotretinoin toxicity in a young male: a case report. Reumatismo, 75(3). https://doi.org/10.4081/reumatismo.2023.1566
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