Original Articles Open access

Oxidative stress may be a contributing factor in fibromyalgia patients’ pain mechanisms

Authors

Published
18 September 2023
Section
Original Articles
DOI
10.4081/reumatismo.2023.1550

Abstract

Objective. The pathophysiology of fibromyalgia (FM), a continuously painful syndrome with no known origin, has been related to mitochondrial dysfunction, oxidative stress, and inflammation. Recent studies have shown that FM may be associated with an oxidative balance disorder. The objective of this study was to measure the levels of oxidative stress in FM patients and try to understand the association between FM and free radicals.

Methods. This study was performed on 100 volunteers admitted to the University of Health Sciences, Sultan 2, Abdulhamid Han Health Application and Research Center Physical Therapy and Rehabilitation Clinic, including 50 healthy controls and 50 patients with FM. To analyze oxidative stress biomarkers, total oxidant status (TOS) and total antioxidant status (TAS) levels were measured. Total thiol (TT) and native thiol (NT) concentrations were measured to determine the relationship between thiol groups. Disulfide (DIS) and oxidative stress index (OSI) were calculated with mathematical formulas.

Results. While TOS and OSI levels were statistically higher in FM patients, TAS levels were significantly lower compared to the healthy control group (p<0.001). In comparison to the healthy control group, FM patients had considerably decreased TT and NT levels. DIS levels were significantly higher in FM patients than in controls (p<0.001).

Conclusions. Reactive oxygen species have several negative impacts on the human body. As a result of the measurements we analyzed, the relationship between FM and oxidative stress should be studied in terms of disease progression and may help improve the treatment process.

Keywords

References

  1. Neumeister MW, Neumeister EL. Fibromyalgia. Clin Plast Surg 2020; 47: 203-13. DOI: https://doi.org/10.1016/j.cps.2019.12.007
  2. Araújo FM, Melo DeSantana J. Physical therapy modalities for treating fibromyalgia. F1000Res 2019; 8: F1000 Faculty Rev-2030. DOI: https://doi.org/10.12688/f1000research.17176.1
  3. Kia S, Choy E. Update on treatment guideline in fibromyalgia syndrome with focus on pharmacology. Biomedicines 2017; 5: 20. DOI: https://doi.org/10.3390/biomedicines5020020
  4. McBeth J, Jones K. Epidemiology of chronic musculoskeletal pain. Best Pract Res Clin Rheumatol 2007; 21: 403-25. DOI: https://doi.org/10.1016/j.berh.2007.03.003
  5. Clauw DJ. Fibromyalgia: a clinical review. JAMA 2014; 311: 1547-55. DOI: https://doi.org/10.1001/jama.2014.3266
  6. Phillips K, Clauw DJ. Central pain mechanisms in the rheumatic diseases: future directions. Arthritis Rheum 2013; 65: 291-302. DOI: https://doi.org/10.1002/art.37739
  7. Wolfe F. Fibromyalgianess. Arthritis Rheum 2009; 61: 715-6. DOI: https://doi.org/10.1002/art.24553
  8. Wolfe F, Häuser W, Hassett AL, Katz RS, Walitt BT. The development of fibromyalgia - I: examination of rates and predictors in patients with rheumatoid arthritis (RA). Pain 2011; 152: 291-9. DOI: https://doi.org/10.1016/j.pain.2010.09.027
  9. Cordero MD, Cano-García FJ, Alcocer-Gómez E, De Miguel M, Sánchez-Alcázar JA. Oxidative stress correlates with headache symptoms in fibromyalgia: coenzyme Q10 effect on clinical ımprovement. PLoS One 2012; 7: e35677. DOI: https://doi.org/10.1371/journal.pone.0035677
  10. Ward JPT. From physiological redox signalling to oxidant stress. Adv Exp Med Biol 2017; 967: 335-42. DOI: https://doi.org/10.1007/978-3-319-63245-2_21
  11. Wang ZQ, Porreca F, Cuzzocrea S, Galen K, Lightfoot R, Masini E, et al. A newly ıdentified role for superoxide in ınflammatory pain. J Pharmacol Exp Ther 2004; 309: 869-78. DOI: https://doi.org/10.1124/jpet.103.064154
  12. Chung CP, Titova D, Oeser A, Randels M, Avalos I, Milne GL, et al. Oxidative stress in fibromyalgia and its relationship to symptoms. Clin Rheumatol 2009; 28: 435-8. DOI: https://doi.org/10.1007/s10067-008-1072-0
  13. Wolfe F, Häuser W. Fibromyalgia diagnosis and diagnostic criteria. Ann Med 2011; 43: 495-502. DOI: https://doi.org/10.3109/07853890.2011.595734
  14. Wolfe F, Walitt BT, Rasker JJ, Katz RS, Häuser W. The use of polysymptomatic distress categories in the evaluation of fibromyalgia (FM) and FM severity. J Rheumatol 2015; 42: 1494-501. DOI: https://doi.org/10.3899/jrheum.141519
  15. Littlejohn GO, Guymer EK. In clinical practice, the term “central sensitivity score” ıs more useful than the term “polysymptomatic distress scale”: comment on the editorial by Wolfe. Arthritis Rheumatol 2015; 67: 2553. DOI: https://doi.org/10.1002/art.39213
  16. Wolfe F. New American college of rheumatology criteria for fibromyalgia: a twenty-year journey. Arthritis Care Res 2010; 62: 583-4. DOI: https://doi.org/10.1002/acr.20156
  17. Siracusa R, Di Paola R, Cuzzocrea S, Impellizzeri D. Fibromyalgia: pathogenesis, mechanisms, diagnosis and treatment options update. Int J Mol Sci 2021; 22: 3891. DOI: https://doi.org/10.3390/ijms22083891
  18. Staud R. Biology and therapy of fibromyalgia: pain in fibromyalgia syndrome. Arthritis Res Ther 2006; 8: 208. DOI: https://doi.org/10.1186/ar1950
  19. Hendrix J, Nijs J, Ickmans K, Godderis L, Ghosh M, Polli A. The ınterplay between oxidative stress, exercise, and pain in health and disease: potential role of autonomic regulation and epigenetic mechanisms. Antioxidants 2020; 9: 1166. DOI: https://doi.org/10.3390/antiox9111166
  20. Ito F, Sono Y, Ito T. Measurement and clinical significance of lipid peroxidation as a biomarker of oxidative stress: oxidative stress in diabetes, atherosclerosis, and chronic ınflammation. Antioxidants 2019; 8: 72. DOI: https://doi.org/10.3390/antiox8030072
  21. Brieger K, Schiavone S, Miller Jr, Krause KH. Reactive oxygen species: from health to disease. Swiss Med Wkly 2012; 142: w13659. DOI: https://doi.org/10.4414/smw.2012.13659
  22. Singh A, Kukreti R, Saso L, Kukreti S. Oxidative stress: a key modulator in neurodegenerative diseases. Molecules 2019; 24: 1583. DOI: https://doi.org/10.3390/molecules24081583
  23. Erel O. A new automated colorimetric method for measuring total oxidant status. Clin Biochem 2005; 38: 1103-11. DOI: https://doi.org/10.1016/j.clinbiochem.2005.08.008
  24. Szarka A, Lőrincz T, Hajdinák P. Friend or foe: the relativity of (anti)oxidative agents and pathways. Int J Mol Sci 2022; 23: 5188. DOI: https://doi.org/10.3390/ijms23095188
  25. Bagis S, Tamer L, Sahin G, Bilgin R, Guler H, Ercan B, et al. Free radicals and antioxidants in primary fibromyalgia: an oxidative stress disorder? Rheumatol Int 2005; 25: 188-90. DOI: https://doi.org/10.1007/s00296-003-0427-8
  26. Çetinkaya FN, Koçak FA, Kurt EE, Güçlü K, Tuncay F, Şaş S, et al. The effects of balneotherapy on oxidant/antioxidant status in patients with fibromyalgia: an observational study. Arch Rheumatol 2020; 35: 506-14. DOI: https://doi.org/10.46497/ArchRheumatol.2020.7857
  27. Karatas G, Gunduz R, Haskul I, Ustun B, Neselioglu S, Karatas F, et al. Dynamic thiol and disulphide homoeostasis in fibromyalgia. Arch Med Sci 2020; 16: 597-602. DOI: https://doi.org/10.5114/aoms.2019.87052
  28. La Rubia M, Rus A, Molina F, Del Moral ML. Is fibromyalgia-related oxidative stress implicated in the decline of physical and mental health status? Clin Exp Rheumatol 2013; 31: S121-7.
  29. Tuzcu A, Baykara RA, Alışık M, Omma A, Acet GK, Dogan E, et al. Alteration of thiol-disulfide homeostasis in fibromyalgia syndrome. Acta Medica 2019; 62: 12-8. DOI: https://doi.org/10.14712/18059694.2019.40
  30. Bazzini P, Wermuth CG. Substituent groups. In: Wermuth CG (ed). The practice of medicinal chemistry. Amsterdam, The Netherlands: Elsevier; 2008. pp. 319-57. DOI: https://doi.org/10.1016/B978-0-12-417205-0.00013-4
  31. Basbaum AI, Bautista DM, Scherrer G, Julius D. Cellular and molecular mechanisms of pain. Cell 2009; 139: 267-84. DOI: https://doi.org/10.1016/j.cell.2009.09.028
  32. Cortright DN, Krause JE, Broom DC. TRP channels and pain. Biochim Biophys Acta 2007; 1772: 978-88. DOI: https://doi.org/10.1016/j.bbadis.2007.03.003

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