Case Reports
3 May 2022
Vol. 74 No. 1 (2022)
https://doi.org/10.4081/reumatismo.2022.1475

Erythema nodosum after COVID-19 vaccine

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Erythema nodosum, dermatology, vaccine, COVID-19, coronavirus.
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Authors

B. Maranini
beatrice.maranini@edu.unife.it
https://orcid.org/0000-0002-7313-3520
Rheumatology Unit, Department of Medical Sciences, University of Ferrara, Italy.
G. Ciancio
Rheumatology Unit, Department of Medical Sciences, University of Ferrara, Italy.
M. Corazza
Section of Dermatology, Department of Medical Sciences, University of Ferrara, Italy.
F. Ruffilli
Rheumatology Unit, Department of Medical Sciences, University of Ferrara, Italy.
G. Galoppini
https://orcid.org/0000-0003-1638-7310
Rheumatology Unit, Department of Medical Sciences, University of Ferrara, Italy.
M. Govoni
https://orcid.org/0000-0003-0499-5773
Rheumatology Unit, Department of Medical Sciences, University of Ferrara, Italy.

The current coronavirus disease 2019 (COVID-19) pandemic is a global challenge with strong medical and socioeconomic implications. Hopes have been placed in the development of various vaccines. As the vaccination campaign is in progress, adverse effects need to be monitored closely. Possible side effects range from minor events to more serious manifestations. In this article, we describe two cases of erythema nodosum (EN) after COVID-19 vaccination in two previously healthy female patients of 59 and 51 years, respectively. Most of the usual etiologies of EN were excluded by laboratory testing. EN was successfully treated with corticosteroids. Remarkably, in the first case, a relapse occurred 48 hours after the second dose of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine. In this case series, we describe two unusual occurrences of EN after vaccination with an mRNA COVID-19 vaccine and a viral vector vaccine, respectively, and we discuss the available related literature.

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Erythema nodosum after COVID-19 vaccine. (2022). Reumatismo, 74(1). https://doi.org/10.4081/reumatismo.2022.1475
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