Leptin: regulatory role in bone metabolism and in flogosis
AbstractLeptin is a peptidic molecule synthesized almost exclusively by adipocytes, that regulates appetite and energy expenditure at the hypothalamic level. In the last few years, further actions have been attributed to this molecule, as modulating the immune response and affecting the bone metabolism. We have reviewed if leptin contributes to the metabolic changes leading to cachexia and to the regulation of flogosis, paying attention to the pathogenetic mechanisms of cronic arthritis. Besides, considering the relationship between body mass index (BMI) e bone mineral density (BMD) and the protective role of the obesity towards osteoporosis, we have analysed the role of leptin on the bone metabolism
- Abstract views: 788
- PDF: 2581
Copyright (c) 1970 G. De Marchi, G.D. Ferraccioli
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.