IgA deficiency evidence after anti-TNF-α treatment in a psoriatic arthritis patient: case report

  • S. Iervolino University of Naples Federico II, Italy.
  • M. Lofrano University of Naples Federico II, Italy.
  • M.N.D. Di Minno University of Naples Federico II, Italy.
  • F. Foglia University Federico II of Naples, Italy.
  • R. Scarpa University of Naples Federico II, Italy.
  • R. Peluso | rosario.peluso2@unina.it University of Naples Federico II, Italy.

Abstract

It is known that the use of anti-TNF-α drugs is related to an increased incidence of infective diseases. This therapy can not be administered to patients having active infections and it has to be considered with caution in case of acquired or congenital immunodeficiency diseases. We report the case of a 28-years-old man affected by psoriatic arthritis; he developed some infections during treatment with TNF-α blockers. The infections were caused by a selective IgA deficiency, that was not evident before the anti-TNF-α blockers administration and disappeared after withdrawing the biological therapy. This case-report draws our attention to the possibility of cases of subclinical immunodeficiency, unknown by the patients, but important in the prognosis and in the therapeutic approach to these diseases. Therefore, it is important to evaluate carefully the immunologic status of patients during the pre-therapeutic screening for TNF-α blocking therapy.

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Author Biographies

S. Iervolino, University of Naples Federico II
Department of Clinical and Experimental Medicine
M. Lofrano, University of Naples Federico II
Department of Clinical and Experimental Medicine
M.N.D. Di Minno, University of Naples Federico II
Department of Clinical and Experimental Medicine
F. Foglia, University Federico II of Naples
Department of Clinical and Experimental Medicine
R. Scarpa, University of Naples Federico II
Department of Clinical and Experimental Medicine
R. Peluso, University of Naples Federico II
Departmento of Clincal and Experimental Medicine
Published
2012-03-19
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Issue
Section
Case Reports
Keywords:
IgA deficiency, TNF-α blocking therapy, psoriatic arthritis, infective diseases
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How to Cite
Iervolino, S., Lofrano, M., Di Minno, M., Foglia, F., Scarpa, R., & Peluso, R. (2012). IgA deficiency evidence after anti-TNF-α treatment in a psoriatic arthritis patient: case report. Reumatismo, 64(1), 40-43. https://doi.org/10.4081/reumatismo.2012.40