https://doi.org/10.4081/reumatismo.2018.1049

Histopathology of the skin in rheumatic diseases

Vol. 70 No. 3 (2018): Monographic issue on Histopathology in Rheumatic Diseases
Published: October 3 2018
Histopathology, cutaneous diseases, autoimmune diseases, skin.
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Authors

M.S. Chimenti
maria.sole.chimenti@uniroma2.it
Rheumatology, Allergology and Clinical Immunology, Department of Medicina dei Sistemi, University of Rome Tor Vergata, Rome, Italy.
A. Di Stefani
Institute of Dermatology, Catholic University of the Sacred Heart, Fondazione Policlinico Universitario A. Gemelli, Rome, Italy.
P. Conigliaro
Rheumatology, Allergology and Clinical Immunology, Department of Medicina dei Sistemi, University of Rome Tor Vergata, Rome, Italy.
A. Saggini
Department of Biomedicine and Prevention, Anatomic Pathology, University of Tor Vergata, Rome, Italy.
S. Urbani
Rheumatology, Allergology and Clinical Immunology, Department of Medicina dei Sistemi, University of Rome Tor Vergata, Rome, Italy.
A. Giunta
Dermatology, Department of Medicina dei Sistemi, University of Rome Tor Vergata, Rome, Italy.
M. Esposito
Dermatology, Department of Medicina dei Sistemi, University of Rome Tor Vergata, Rome, Italy.
L. Bianchi
Dermatology, Department of Medicina dei Sistemi, University of Rome Tor Vergata, Rome, Italy.
K. Peris
Institute of Dermatology, Catholic University of the Sacred Heart, Fondazione Policlinico Universitario A. Gemelli, Rome, Italy.
R. Perricone
Rheumatology, Allergology and Clinical Immunology, Department of Medicina dei Sistemi, University of Rome Tor Vergata, Rome, Italy.

Rheumatological systemic autoimmune diseases, such as connective tissue diseases, rheumatoid arthritis or spondyloarthritis, are characterized by the presence of joint involvement associated with extra-articular manifestations. Among them, cutaneous diseases are often the most relevant and representative clinical manifestation, as in psoriatic arthritis, scleroderma or systemic lupus erythematosus. In this context, it is useful for rheumatologists to understand better skin diseases and their histopathological features. Evaluation of skin biopsy specimens can be helpful not only to confirm the diagnosis in both classic and clinically atypical variants, but also to improve further our knowledge of the pathogenetic mechanisms and the close link between skin and articular diseases. In this review, we discuss the clinical features, diagnostic evaluation and the histopathological features of skin manifestation of the most relevant rheumatological autoimmune diseases.

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Histopathology of the skin in rheumatic diseases. (2018). Reumatismo, 70(3), 187-198. https://doi.org/10.4081/reumatismo.2018.1049

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