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• S02:5 | Combined anti-IL-5/IL-5r and dupilumab therapy in eosinophilic granulomatosis with polyangiitis: a European retrospective study Miriam Guerini¹, Pavel Novikov², Roberto Padoan³, Georgina Espigol Frigolé⁴, Jan Willem Cohen Tervaert⁵, Vincent Grobost⁶, Laurent Guilleminault⁷, Jan Walter Schroeder⁸, Bernhard Hellmich⁹, Joana Martins Martinho¹⁰, Camillo Ribi¹¹, Matthieu Groh¹², Benjamin Terrier¹³. | ¹IRCCS Policlinico S. Matteo, University of Pavia, Pavia, Italy; ²Sechenov University, Moscow, Russia; ³University of Padova, Padova, Italy; ⁴Hospital Clinic, University of Barcelona, Barcelona, Spain; ⁵University of Alberta, Edmonton, Canada; ⁶CHU Estaing Clermont-Ferrand France; ⁷Toulouse University Toulouse France; ⁸ASST Grande Ospedale Metropolitano Niguarda, Milano, Italy; ⁹Medius Kliniken Kirchheim-Teck Germany; ¹⁰ULS Santa Maria, Lisbon, Portugal; ¹¹Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland; ¹²Hopital Foch, Suresnes, France; ¹³Service de Medecine interne, Hopital Cochin, AP-HP, Paris, France.

  Società Italiana di Reumatologia

  26-11-2025

  https://doi.org/10.4081/reumatismo.2025.2101

  133

• PO:35:219 | Real-world effectiveness of mepolizumab on gastrointestinal involvement in eosinophilic granulomatosis with polyangiitis and hypereosinophilic syndrome: a multicentre retrospective study Alessia Gatti¹, Francesca Regola¹, Giulia Fontana¹, Mario Addrea Piga², Gianluca Moroncini², Palma Carlucci³, Angelo Vacca³, Paolo Delvino⁴, Enrico Heffler⁵, Emanuele Nappi⁵, Jakub Moll⁶, Laura Losappio⁶, Jan Schroeder⁶, Federica Davanzo⁷, Roberto Padoan⁷, Edoardo Conticini⁸, Paolo Cameli⁸, Greta Pacini⁹, Alvise Berti⁹, Lorenzo Vrola¹⁰, Paola Tomietto¹⁰, Luca Quartuccio¹¹, Jan Willem Cohen Tervaert¹², Sabrina Arnold¹³, Peter Lamprecht¹³, Florence Roufosse¹⁴, Ilaria Cavazzana¹, Franco Franceschini¹, Giacomo Emmi¹⁵, Paola Toniati¹. | ¹Rheumatology and Clinical Immunology Unit, ERN ReCONNET, ASST Spedali Civili of Brescia and University of Brescia, Italy, Brescia, Italy; ²Università Politecnica delle Marche and Azienda Ospedaliero Universitaria delle Marche, Ancona, Italy, Ancona, Italy; ³Section of Internal Medicine 'Guido Baccelli', DiMePRe-J, University of Bari 'Aldo Moro', Bari, Italy, Bari, Italy; ⁴Rheumatology Unit, IRCCS San Gerardo dei Tintori, Monza, Italy Monza Italy; ⁵Department of Biomedical Sciences, Humanitas University and Personalized Medicine, Asthma and Allergy IRCCS Humanitas, Milano, Italy; ⁶Division of Allergy and Clinical Immunology, ASST GOM Niguarda, Milan, Italy, Milano, Italy; ⁷Rheumatology Unit, Department of Medicine DIMED, University of Padua, Padova, Italy, Padova, Italy; ⁸University of Siena, Siena, Italy, Siena, Italy; ⁹Santa Chiara Hospital and University of Trento, Unit of Rheumatology, Trento, Italy Trento Italy; ¹⁰UCO Medicina Clinica, ASUGI, Cattinara Teaching Hospital, Trieste, Italy, Trieste, Italy; ¹¹Division of Rheumatology, Department of Medicine ^DMED, University of Udine, Udine, Italy, Udine, Italy; ¹²University of Alberta, Edmonton, Alberta, Canada and Maastricht University, Maastricht, The Netherlands Maastricht The Netherlands; ¹³Department of Rheumatology and Clinical Immunology, University of Lübeck, Lübeck, Germany Lubeck Germany; ¹⁴Department of Internal Medicine, Hôpital Universitaire de Bruxelles - Erasme, Université Libre de Bruxelles, Belgium Brussels Belgium; ¹⁵Clinical Medicine and Clinical Immunology and Rheumatology Unit Cattinara University Hospital and University of Trieste, Trieste, Italy.

  Società Italiana di Reumatologia

  26-11-2025

  https://doi.org/10.4081/reumatismo.2025.2086

  111