Predictors of thickened carotid intima media thickness among well controlled lupus nephritis patients in a Malaysian tertiary centre

Submitted: 11 March 2012
Accepted: 18 July 2012
Published: 20 December 2012
Abstract Views: 2040
PDF: 843
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Authors

Objectives. To investigate the prevalence of thickened carotid intima media thickness (CIMT) and its associated risk factors in patients with lupus nephritis (LN) who were in remission. Methods. This was a cross sectional study in which consecutive LN patients who were in remission and attending our Nephrology/SLE Clinic were included. Their demographic profile, traditional cardiovascular risk factors and treatment medications were evaluated by clinical interview and review of medical records. Carotid intima media thickness (CIMT) was measured using B Mode carotid ultrasonography. CIMT was considered to be abnormally thickened if it exceeded the 75th percentile matched for age-and sex-matched normal controls. The associated factors for thickened CIMT were examined. Results. A total of 39 patients with a mean remission duration of 29±24.3 months and on a mean prednisolone dose of 9.10±7.83 mg daily completed the study. Six patients (15.4%) had thickened CIMT. On univariate analysis, male gender, patient age, older age at diagnosis, higher serum CRP levels, greater proteinuria and higher mean cumulative azathioprine dose were associated with thickened CIMT (P<0.05). Lower mean cumulative doses of cyclosporine A (CyA) and mycophenolic acid (MPA) (P<0.05) each were associated with thickened CIMT. Using regression analysis, the associated factors of CIMT were older age at diagnosis and proteinuria. Conclusions. Lupus factors particularly age at diagnosis and proteinuria were the associated factors of thickened CIMT. Larger prospective trials are indicated to confirm our findings.

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S.S. Shaharir, Universiti Kebangsaan Malaysia Medical Centre

Clinical Specialist,

Department of Internal Medicine

M.S. Mohamed Said, Universiti Sains Islam Malaysia
Consultant Rheumatologist
N.CT. Kong, Universiti Kebangsaan Malaysia Medical Centre
COnsultant Nephrologist

How to Cite

Shaharir, S., Mohamed Said, M., & Kong, N. (2012). Predictors of thickened carotid intima media thickness among well controlled lupus nephritis patients in a Malaysian tertiary centre. Reumatismo, 64(6), 341–349. https://doi.org/10.4081/reumatismo.2012.341

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