https://doi.org/10.4081/reumatismo.2017.976

Mesenchimal stem cells: a possible role in the pathogenesis and treatment of spondyloarthritis

Vol. 69 No. 1 (2017)
Submitted: 8 February 2017
Accepted: 13 March 2017
Published: 22 May 2017
Spondyloarthritis, Mesenchimal stem cells, Pathogenesis, Treatment.
Abstract Views: 2350
PDF: 1428
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Authors

F.M. Perrotta
Department of Medicine and Health Sciences “Vincenzo Tiberio”, University of Molise, Campobasso, Italy.
G. Guerra
Department of Medicine and Health Sciences “Vincenzo Tiberio”, University of Molise, Campobasso, Italy.
A. De Socio
Department of Medicine and Health Sciences “Vincenzo Tiberio”, University of Molise, Campobasso, Italy.
S. Scriffignano
Department of Medicine and Health Sciences “Vincenzo Tiberio”, University of Molise, Campobasso, Italy.
E. Lubrano
enniolubrano@hotmail.com
Department of Medicine and Health Sciences “Vincenzo Tiberio”, University of Molise, Campobasso, Italy.
Spondyloarthritis (SpAs) are a group of chronic inflammatory diseases that affect joints and enthesis with a possible involvement of other districts such as skin, eye and bowel. In SpAs, the inflammatory process could lead to both erosive damage (as in peripheral joint involvement of psoriatic arthritis), or bone formation (as in ankylosing spondylitis) with a reduction in function and quality of life. Recently, Mesenchimal stem cells (MSCs) transplant was used in different diseases, including autoimmune and inflammatory diseases, with the aim of repairing tissue damage, exploiting their regenerative capacity. However, MSCs also proved to have an immune-modulatory capacity due to their interaction with the cells of the immune system. The aim of this brief paper was to review the possible pathogenic role and the new perspective of MSCs use in SpAs.

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F.M. Perrotta, Department of Medicine and Health Sciences “Vincenzo Tiberio”, University of Molise, Campobasso
Dipartimento di Medicina e Scienze della Salute, MD
G. Guerra, Department of Medicine and Health Sciences “Vincenzo Tiberio”, University of Molise, Campobasso
Dipartimento di Medicina e Scienze della Salute, MD, PhD
A. De Socio, Department of Medicine and Health Sciences “Vincenzo Tiberio”, University of Molise, Campobasso
Dipartimento di Medicina e Scienze della Salute, MD
E. Lubrano, Department of Medicine and Health Sciences “Vincenzo Tiberio”, University of Molise, Campobasso
Dipartimento di Medicina e Scienze della Salute, MD, PhD

How to Cite

Perrotta, F., Guerra, G., De Socio, A., Scriffignano, S., & Lubrano, E. (2017). Mesenchimal stem cells: a possible role in the pathogenesis and treatment of spondyloarthritis. Reumatismo, 69(1), 1–8. https://doi.org/10.4081/reumatismo.2017.976

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