TY - JOUR AU - Hosseinzadeh, A. AU - Soukhtehzari, S. AU - Ghaedi, M. AU - Mansouri, R. PY - 2016/12/31 Y2 - 2024/03/29 TI - Metabolism plays the key roles in Th cells differentiation JF - Reumatismo JA - Reumatismo VL - 68 IS - 4 SE - Reviews DO - 10.4081/reumatismo.2016.919 UR - https://www.reumatismo.org/reuma/article/view/919 SP - 176-182 AB - The increasing rate of autoimmunity in recent decades cannot be related to only genetic instabilities and disorders. Diet can directly influence our health. Studies have shown that there is a relationship between nutritional elements and alteration in the immune system. Among immune cells, the function of T lymphocyte is important in directing immune response. T CD4+ cells lead other immune cells to respond to pathogens by secreting cytokines. HIV+ patients, who have largely lost their T CD4+ cells, are susceptible to opportunistic infections, which do not normally affect healthy people. It seems that the metabolism of T cells is critical for their differentiation and their consequent functions. After activation, T cells need to undergo clonal expansion, which is a high energy- consuming process. Studies have shown that specific metabolites deprivation or their excess supply affects T CD4+cells subsets differentiation. Abnormal induction of subsets of T CD4+ cells causes some autoimmunity reactions and hyper-sensitivity as well, which may result from imbalance of diet uptake. In this mini-review, we describe the findings about fatty acids, glucose, amino acids, and vitamins, which are effective in determining the fates of T CD4+ cells. These findings may help us uncover the role of diet in autoimmune diseases. ER -