TY - JOUR AU - Koh, K.T. AU - Teh, C.L. AU - Cheah, C.K. AU - Ling, G.R. AU - Yong, M.C. AU - Hong, H.C. AU - Gun, S.C. PY - 2016/09/09 Y2 - 2024/03/29 TI - Real-world experiences of folic acid supplementation (5 versus 30 mg/week) with methotrexate in rheumatoid arthritis patients: a comparison study JF - Reumatismo JA - Reumatismo VL - 68 IS - 2 SE - Articles DO - 10.4081/reumatismo.2016.872 UR - https://www.reumatismo.org/reuma/article/view/872 SP - 90-96 AB - The objective of this study was to compare the tolerability of methotrexate in two different regimes of folic acid (FA) supplementation in rheumatoid arthritis (RA). We performed a multicenter, cross-sectional observational cohort study on 240 RA patients with 120 patients each in 5 mg of FA weekly and 30 mg of FA weekly supplementation. There were no significant differences for side effects (14.2 versus 22.5%, P=0.523) and discontinuation of methotrexate (3.6 versus 13.3%, P=0.085). RA patients given 5 mg of FA weekly supplementation had a lower disease activity score 28 compared to 30 mg of FA weekly supplementation [3.44 (1.10) versus 3.85 (1.40), P=0.014]. FA supplementation of 5 mg per week and 30 mg per week was associated with similar tolerability of methotrexate in RA patients. ER -