TY - JOUR AU - Pasero, G. AU - Marson, P. PY - 2010/09/30 Y2 - 2024/03/29 TI - A short history of anti-rheumatic therapy. III. Non steroidal anti-inflammatory drugs JF - Reumatismo JA - Reumatismo VL - 62 IS - 3 SE - Survey/Comments DO - 10.4081/reumatismo.2010.225 UR - https://www.reumatismo.org/reuma/article/view/reumatismo.2010.225 SP - 225-232 AB - The chemical advances of the 20th century led to the synthesis of non steroidal anti-inflammatory drugs (NSAIDs), beginning from phenylbutazone and indomethacin and continuing with other new drugs, including ibuprofen, diclofenac, naproxen, piroxicam and, more recently, the highly selective COX-2 inhibitors (coxibs). This progress derived from the discovery of the mechanism of action of these drugs: the inhibition of synthesis of prostaglandins due to the cycloxigenase enzyme system, according to the experimental contributions of John R. Vane. ER -