TY - JOUR AU - Valesini, G. PY - 2005/12/30 Y2 - 2024/03/29 TI - Are there differences among anti-TNFa biological drugs? JF - Reumatismo JA - Reumatismo VL - 57 IS - s4 SE - Articles DO - 10.4081/reumatismo.2005.4s.1 UR - https://www.reumatismo.org/reuma/article/view/reumatismo.2005.4s.1 SP - 1-2 AB - Objective: To provide an analysis and a guide tool in using TNFa-antagonists in the current clinical practice. Methods: Review of the literature on the differences among the three TNFa-antagonists in terms of molecular structure, mechanism of action, pharmacokinetics, effects on the immune and neuroendocrine systems, and therapeutic indications. Results and conclusions: Unfortunately, results of direct comparison studies are lacking. One could obviate this problem by performing statistical-mathematical extrapolations, but there are very few and very small-sized published experimental evidences. ER -