TY - JOUR AU - Chessa, E. AU - Piga, M. AU - Floris, A. AU - Mathieu, A. AU - Cauli, A. PY - 2017/12/21 Y2 - 2024/03/28 TI - Demyelinating syndrome in SLE: review of different disease subtypes and report of a case series JF - Reumatismo JA - Reumatismo VL - 69 IS - 4 SE - Articles DO - 10.4081/reumatismo.2017.1007 UR - https://www.reumatismo.org/reuma/article/view/1007 SP - 175-183 AB - Demyelinating syndrome (DS) is a rare manifestation of systemic lupus erythematosus (SLE) (1%) with high clinical heterogeneity and potentially severe prognosis. It can represent a diagnostic and therapeutic challenge for clinicians. A recent study described 5 different patterns of demyelinating disease presentation, characterised by specific clinical, laboratory and brain and spine magnetic resonance imaging abnormalities: 1) neuromyelitis optica; 2) neuromyelitis optica spectrum disorders; 3) DS prevalently involving the brain; 4) DS prevalently involving the brainstem; 5) clinically isolated syndrome. In this review we briefly discuss typical characteristics of each DS presentation in SLE and we describe 5 illustrative clinical cases, one for each subset of DS, considering both diagnostic and therapeutic options. ER -