Vitamin D and rheumatic diseases

  • M. Rossini | maurizio.rossini@univr.it Rheumatology Unit, University of Verona, Italy.
  • D. Gatti Rheumatology Unit, University of Verona, Italy.
  • O. Viapiana Rheumatology Unit, University of Verona, Italy.
  • C. Caimmi Rheumatology Unit, University of Verona, Italy.
  • L. Idolazzi Rheumatology Unit, University of Verona, Italy.
  • E. Fracassi Rheumatology Unit, University of Verona, Italy.
  • S. Adami Rheumatology Unit, University of Verona, Italy.

Abstract

Vitamin D has some well-known effects on calcium, phosphate and bone metabolism, but it has recently shown to have many other effects, which may potentially be relevant to patients with extra-skeletal rheumatic diseases. Such effects may be justified by: 1) the presence of the vitamin D receptors also on extra-osseous cells, such as cartilage cells, sinoviocytes, muscle cells; 2) the proven role of vitamin D in the control of the transcription of genes involved in rheumatic diseases; 3) the evidence that vitamin D has multiple endocrine effects not only on calcium homeostasis; 4) the activation of vitamin D not only in the kidneys, but also in monocyte-macrophage and lymphocytic cell lines and in some epithelial cells with additional intracrine and paracrine effects. Vitamin D deficiency has been reported in numerous metabolic, degenerative, inflammatory and autoimmune rheumatic diseases. In some cases this association was also related to the risk of developing a rheumatic disease or the degree of disease activity. However there is no conclusive evidence of the efficacy of a preventive or therapeutic strategy based on vitamin D supplementation in extra-skeletal rheumatic diseases. This review aims to provide an overview of the latest evidence concerning the relationship between vitamin D and the most relevant rheumatic diseases.

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Published
2014-07-28
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Section
Reviews
Keywords:
Vitamin D, Rheumatic diseases.
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How to Cite
Rossini, M., Gatti, D., Viapiana, O., Caimmi, C., Idolazzi, L., Fracassi, E., & Adami, S. (2014). Vitamin D and rheumatic diseases. Reumatismo, 66(2), 153-170. https://doi.org/10.4081/reumatismo.2014.788

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