Intra-articular therapy with tumor necrosis factor-α antagonists: an update

  • S. Bello | s.bello1@virgilio.it Rheumatology Unit, Policlinico Hospital, University of Bari, Italy.
  • C. Bonali Rheumatology Unit, Policlinico Hospital, University of Bari, Italy.
  • L. Serafino Rheumatology Unit, Policlinico Hospital, University of Bari, .
  • C. Rotondo Rheumatology Unit, Policlinico Hospital, University of Bari, .
  • N. Terlizzi Rheumatology Unit, Policlinico Hospital, University of Bari, .
  • G. Lapadula Rheumatology Unit, Policlinico Hospital, University of Bari, Italy.

Abstract

The aim of the study was to review from the present literature the intra-articular (IA) use of the TNF-blocking drugs. A total of 28 papers about this topic were found through a search in PubMed; the first publication’s date was July 2003. These studies include a total of 214 patients affected by 12 different joint diseases that reported a total of 1046 intra-articular therapies carried out in 10 different joint sites. Infliximab and etanercept were the most widely used medications. The safety of this treatment clearly emerges from our analysis, while more difficult was the evaluation of its efficacy. Nevertheless we deduced an ideal patient profile that may better respond to the IA anti-TNF treatment.

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Author Biography

S. Bello, Rheumatology Unit, Policlinico Hospital, University of Bari
Già borsista,attualmente collaboratore esterno con finalità di ricerca,presso ambulatorio dedicato alle terapie biologiche,
Published
2014-03-14
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Section
Reviews
Keywords:
intra-articular therapy, sieronegative spondyloarthritis, anti-TNF agents, refractory monoarthritis.
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How to Cite
Bello, S., Bonali, C., Serafino, L., Rotondo, C., Terlizzi, N., & Lapadula, G. (2014). Intra-articular therapy with tumor necrosis factor-α antagonists: an update. Reumatismo, 65(6), 257-263. https://doi.org/10.4081/reumatismo.2013.721