Secondary hemophagocytic lymphohistiocytosis possibly induced by interferon beta-1a therapy.

  • C. Cosso | claudio.cosso86@gmail.com Clinica Reumatologica, Dipartimento di Medicina Interna, Università di Genova, Italy.
  • R. Cosso Divisione di Medicina Generale, Ospedale A. Gallino, Genova, Italy.
  • M.A. Cimmino Clinica Reumatologica, Dipartimento di Medicina Interna, Università di Genova, Italy.

Abstract

A 57-year old woman with a history of multiple sclerosis, treated with interferon beta-1a in the last 5 months, was referred for hyperpyrexia (>40°C) that persisted for 15 days. At admission, there was elevation of transaminases, anemia (hemoglobin 8.9 g/dL), thrombocytopenia (platelet 135,000/mm3), and hypofibrinogenemia (fibrinogen 1.26 g/L). C-reactive protein was 10.7 mg/dL, lactate dehydrogenase 1270 U/L and ferritin 2380 ng/ mL, with hepatosplenomegaly and linfoadenomegaly. Hemophagocytic lymphohistiocytosis induced by direct stimulation of macrophages by interferon (IFN) was suspected. IFN was withdrawn as only measure and onemonth later signs and symptoms disappeared, with complete normalization of laboratory examinations.

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Published
2013-12-18
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Issue
Section
Case Reports
Keywords:
Interferon, Hemophagocytosis, Macrophage activation syndrome, Hemophagocytic lymphohistiocytosis, Multiple sclerosis.
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How to Cite
Cosso, C., Cosso, R., & Cimmino, M. (2013). Secondary hemophagocytic lymphohistiocytosis possibly induced by interferon beta-1a therapy. Reumatismo, 65(5), 253-255. https://doi.org/10.4081/reumatismo.2013.253