Psoriatic arthritis: genetics and pathogenesis

  • A. Cauli Policlinico of the University of Cagliari, Italy.
  • A. Mathieu | mathieu@medicina.unica.it Policlinico of the University of Cagliari, Italy.

Abstract

Psoriatic arthritis is a complex disease affecting primarily peripheral and axial joints and entheses together with the skin. The pathogenesis is characterized by a genetic background and by inflammatory mechanisms which may be triggered by environmental factors. Several susceptibility genes have been investigated; they include HLA genes, genes within the HLA region and genes outside the HLA region. T cells, including the recently described subset Th17, are thought to play an important role in the acute and chronic phases of the disease. Some of these findings allowed novel therapeutic interventions or opened new promising approaches in treatment. The most relevant data of the literature are summarized and discussed.

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Author Biographies

A. Cauli, Policlinico of the University of Cagliari
Rheumatology Unit, Department of Medical Sciences
A. Mathieu, Policlinico of the University of Cagliari

Department of Medical Sciences, Rheumatology Unit

Published
2012-06-05
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Section
Reviews
Keywords:
Psoriatic arthritis, genetics, pathogenesis, susceptibility, Th17, synovium, skin, enthesis
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How to Cite
Cauli, A., & Mathieu, A. (2012). Psoriatic arthritis: genetics and pathogenesis. Reumatismo, 64(2), 71-78. https://doi.org/10.4081/reumatismo.2012.71