MicroRNAs in autoimmune rheumatic diseases

  • M. Galeazzi U.O.C. Reumatologia, Dipartimento Medicina Clinica e Scienze Immunologiche, Università di Siena, Italy.
  • E. Balistreri U.O.C. Reumatologia, Dipartimento Medicina Clinica e Scienze Immunologiche, Università di Siena, Italy.
  • C. Giannitti U.O.C. Reumatologia, Dipartimento Medicina Clinica e Scienze Immunologiche, Università di Siena, Italy.
  • G.D. Sebastiani | gsebastiani@scamilloforlanini.rm.it UOC Reumatologia - Azienda Ospedaliera San Camillo-Forlanini, Roma, Italy.

Abstract

The etiology of autoimmune diseases remains largely unknown. In recent years, besides genetic factors, several studies proposed that the epigenome may hold the key to a better understanding of autoimmunity initiation and perpetuation. More specifically epigenetic regulatory mechanisms comprise DNA methylation, a variety of histone modifications, and microRNA (miRNA) activity, all of which act upon gene and protein expression levels. In particular it is well known that epigenetic mechanisms are important for controlling the pattern of gene expression during development, the cell cycle, and the response to biological or environmental changes. In the present review a description of the most frequent epigenetic deregulations, in particular the role of miRNA, in rheumatic autoimmune disorders will be analyzed.

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Published
2012-03-16
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Issue
Section
Reviews
Keywords:
autoimmune disease, epigenetics, microRNAs
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How to Cite
Galeazzi, M., Balistreri, E., Giannitti, C., & Sebastiani, G. (2012). MicroRNAs in autoimmune rheumatic diseases. Reumatismo, 64(1), 7-17. https://doi.org/10.4081/reumatismo.2012.7