‘ASIA’ - Autoimmune/inflammatory syndrome induced by adjuvants: even and odd

  • C. Perricone | carlo.perricone@gmail.com Reumatologia, Dipartimento di Medicina Interna e Specialità Mediche, Sapienza Università di Roma, Italy.
  • C. Alessandri Reumatologia, Dipartimento di Medicina Interna e Specialità Mediche, Sapienza Università di Roma, Italy.
  • G. Valesini Reumatologia, Dipartimento di Medicina Interna e Specialità Mediche, Sapienza Università di Roma, Italy.

Abstract

Recently, Shoenfeld and Agmon-Levin described a potential new syndrome, namely ASIA - autoimmune/inflammatory syndrome induced by adjuvants, that comprises four medical conditions: siliconosis, the Gulf war syndrome, the macrophagic myofasciitis syndrome and post-vaccination phenomena, characterized by hyperactive immune responses accompanied by a similar complex of signs and symptoms. Most relevantly, these conditions share a linkage represented by adjuvants. This common soil may possibly induce autoimmune or auto-inflammatory diseases in humans as it was demonstrated in different animal models. Reconsidering under a unified umbrella this apparently detached condition is not only intriguing, but also provocative, and may help in unraveling novel pathogenetic mechanisms, preventive measures, and therapeutic targets.

Dimensions

Altmetric

PlumX Metrics

Downloads

Download data is not yet available.
Info
Issue
Section
Editorials
Keywords:
Autoimmunity, adjuvant, vaccine, silicone.
Statistics
  • Abstract views: 2031

  • PDF: 1050
How to Cite
Perricone, C., Alessandri, C., & Valesini, G. (1). ‘ASIA’ - Autoimmune/inflammatory syndrome induced by adjuvants: even and odd. Reumatismo, 63(2), 63-66. https://doi.org/10.4081/reumatismo.2011.63