Metabolism of crystals within the joint

  • F. Oliviero University of Padova, Italy.
  • A. Scanu University of Padova, Italy.
  • L. Punzi | punzireu@unipd.it University of Padova, Italy.

Abstract

Monosodium urate (MSU), calcium pyrophosphate dihydrate (CPPD) and basic calcium phosphate (BCP) crystals deposit in joints and surrounding tissues causing acute inflammation and chronic cartilage damage. A number of endogenous substances and physicochemical conditions affect their precipitation, growth and even dissolution, regulating their metabolism and inflammatory activity. We review how MSU and calcium crystals form within the joints and the various factor which regulate their formation.

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Author Biographies

F. Oliviero, University of Padova
Rheumatology Unit, Department of Clinical and Experimental Medicine
A. Scanu, University of Padova
Rheumatology Unit, Department of Clinical and Experimental Medicine
L. Punzi, University of Padova
Rheumatology Unit, Department of Clinical and Experimental Medicine
Keywords:
monosodium urate, pyrophosphate, basic calcium phosphate, crystals, metabolism
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How to Cite
Oliviero, F., Scanu, A., & Punzi, L. (1). Metabolism of crystals within the joint. Reumatismo, 63(4), 221-229. https://doi.org/10.4081/reumatismo.2011.221