Citrullination: the loss of tolerance and development of autoimmunity in rheumatoid arthritis
AbstractRheumatoid arthritis (RA) is a chronic inflammatory disease characterized by synovial inflammation and pannus formation, which can lead to severe destruction of cartilage and bone. Several self proteins have been suggested to be disease-driving autoantigens. Moreover the presence of autoantibodies to citrullinated proteins in sera of patients with RA enhances the strength of this hypothesis. Proteins are encoded by a limited number of genes in our genome. Post-translational modifications such as phosphorylation, glycosylation and citrullination can increase the morphological and the functional diversity of the proteome.
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Copyright (c) 1970 S. Alivernini, A.L. Fedele, I. Cuoghi, B. Tolusso, G. Ferraccioli
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