Citrullination: the loss of tolerance and development of autoimmunity in rheumatoid arthritis

Abstract

Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by synovial inflammation and pannus formation, which can lead to severe destruction of cartilage and bone. Several self proteins have been suggested to be disease-driving autoantigens. Moreover the presence of autoantibodies to citrullinated proteins in sera of patients with RA enhances the strength of this hypothesis. Proteins are encoded by a limited number of genes in our genome. Post-translational modifications such as phosphorylation, glycosylation and citrullination can increase the morphological and the functional diversity of the proteome.

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How to Cite
Alivernini, S., Fedele, A., Cuoghi, I., Tolusso, B., & Ferraccioli, G. (1). Citrullination: the loss of tolerance and development of autoimmunity in rheumatoid arthritis. Reumatismo, 60(2), 85-94. https://doi.org/10.4081/reumatismo.2008.85

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