https://doi.org/10.4081/reumatismo.2008.224

Relationship between delayed menarche and bone density in patients affected by juvenile

Vol. 60 No. 3 (2008)
Abstract Views: 949
PDF: 766
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Authors

A. Lurati
office@pagepress.org
R. Cimaz
M. Gattinara
V. Gerloni
B. Teruzzi
A. Salmaso
F. Fantini
Background: Puberty is an essential step in bone mass accrual. Growth failure and impairment of sexual maturation are frequent manifestations of chronic illnesses in the paediatric population, and chronic rheumatologic disorders such as juvenile idiopathic arthritis (JIA) are no exception to this. Methods: The aim of our study was to prospectively evaluate bone density in adolescents females with JIA, and to correlate the results with clinical variables, in particular with age at menarche. Lumbar spine (L2-L4) areal bone mineral density (aBMD) (assessed by Dual X-ray Absorbiometry, DXA) was monitored every 6-12 months in a group of 38 girls with JIA. The evaluated bone density accrual during the peripubertal time as well as absolute and relative (Z-score) aBMD in relationship with age at menarche, JIA subset, disease activity (as evaluated by ESR and Hgb), corticosteroid and methotrexate treatment (mean pro kg daily dose, cumulative dose) was assessed. Height, body mass index (BMI), bone mass content (BMC) values were also collected. Volumetric BMD (vBMD) evaluated with a geometric correction formula has been calculated and compared to aBMD. Results: Patients were divided into two groups: - group I included girls with menarche age within normal limits for italian standards; - group II included girls with delayed menarche. The BMD values and Z scores in group I were not significantly different to normal population. The BMD values and Z scores in group II were significantly decreased when compared to the normal population (p<0.001). With a multivariate analysis only age at menarche seemed independently related to peripubertal mineralization (p=0.025, r between -0.65 and -0.75). With a binary logistic analysis only disease activity (ESR and Hgb values) seems independently related to a menarche delay (1.24±0.4 for each mm/h). Conclusion: Our data show a critical role for disease activity in determination of a regular pubertal onset and an optimal bone density achievement.

Dimensions

Altmetric

PlumX Metrics

Downloads

Download data is not yet available.

Citations

Crossref
Scopus
Google Scholar
Europe PMC

How to Cite

Lurati, A., Cimaz, R., Gattinara, M., Gerloni, V., Teruzzi, B., Salmaso, A., & Fantini, F. (2008). Relationship between delayed menarche and bone density in patients affected by juvenile. Reumatismo, 60(3), 224–229. https://doi.org/10.4081/reumatismo.2008.224

Authors who publish with this journal agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.