Sjogren’s syndrome: apoptosis by anti-SSA and anti-SSB antibodies

Abstract Views: 1173
PDF: 1098
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Authors

The pathogenesis of the Sjogren’s Syndrome (SjS) has not yet been completely defined. However, the cell-mediated immunity plays an important role and the apoptosis of the ductal and acinar epithelial cells is responsible of the glandular tissue damage, through the cytotoxic T-cells, particularly of the CD4+ subpopulation, by the release of proteases (such as perforin and granzyme B) and by the interaction of the Fas Ligand (FasL; CD95L) of the T-lymphocytes, with the Fas (Apo-1; CD95) of the epithelial cells. The apoptotic death of the epithelial cells is the autocrine Fas/FasL interaction also. The anti-SSA and anti-SSB antibodies are the immunological markers of the Sjogren’s syndrome, but it is not yet understood if they have pathogenetic implications....

Dimensions

Altmetric

PlumX Metrics

Downloads

Download data is not yet available.

Citations

How to Cite

Scagliusi, P., D’Amore, M., D’Amore, S., & Scagliusi, A. (2006). Sjogren’s syndrome: apoptosis by anti-SSA and anti-SSB antibodies. Reumatismo, 58(2), 165–166. https://doi.org/10.4081/reumatismo.2006.165