Therapeutic gene transfer for rheumatoid arthritis
AbstractRheumatoid arthritis (RA) is a common and severe disease. Its prevalence in adults is about 0.5%. It not only causes joint pain and severe disability but also increases mortality. RA is an inflammatory autoimmune disease whose the inciting stimulus is unknown, but the cascade of immunological and inflammatory reactions has been elucidated. These reactions produce inflammatory synovitis promptly followed by irreversible joint and bone destruction (1). Available treatments for RA fail to provide long-lasting control of the symptoms or disease progression. The beneficial effects of conventional second-line therapy are incomplete and usually short-lived, despite the progress brought by the introduction of methotrexate in the 1980s....
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