Prevalence and clinical significance of cathepsin G antibodies in systemic sclerosis

  • P. Grypiotis |
  • A. Ruffatti
  • F. Cozzi
  • R.A. Sinico
  • M. Tonello
  • A. Radice
  • M. Favaro
  • S. Todesco


Objectives: To evaluate the prevalence and clinical significance of cathepsin G antibodies in patients affected with systemic sclerosis (SSc, scleroderma). Methods: 115 patients affected by SSc, 55 (47,8%) with diffuse scleroderma (dSSc) and 60 (52,2%) with limited scleroderma (lSSc), were tested for cathepsin G antibodies by ELISA method. Moreover these sera were evaluated by indirect immunofluorescence (IIF) on ethanol and formalin fixed human neutrophils. Results: By means of the ELISA method 16 (13,9%) patients were found to be sera positive for anti-cathepsin G, 2 (12.5%) of which showed a perinuclear fluorescence pattern (P-ANCA) and 4 (25%) an atypical ANCA staining, while 10 (62,5%) were negative on IIF. The IIF on scleroderma sera revealed 5 (4,3%) P-ANCA and 18 (15,7%) atypical ANCA patterns. The anti-cathepsin G antibodies significantly prevailed in scleroderma sera (p=0.02) when their frequency was compared with that of healthy controls; while they were not significantly associated to any clinical or serological features of SSc patients. Conclusions: The anti-cathepsin G antibodies were significantly frequent in scleroderma sera; however, no clinical correlations were found. Thus, the significance of their presence in SSc still needs to be clarified.



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How to Cite
Grypiotis, P., Ruffatti, A., Cozzi, F., Sinico, R., Tonello, M., Radice, A., Favaro, M., & Todesco, S. (1). Prevalence and clinical significance of cathepsin G antibodies in systemic sclerosis. Reumatismo, 55(4), 256-262.

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