Clinical significance of fluoroscopic patterns specific for the mitotic spindle in patients with reumatic diseases

  • P. Grypiotis | office@pagepress.org
  • A. Ruffatti
  • M. Tonello
  • C. Winzler
  • C. Radu
  • S. Zampieri
  • M. Favaro
  • A. Calligaro
  • S. Todesco

Abstract

Objective: we proposed to determine the clinical significance of anti-NuMA and anti-HsEg5 antibodies in a group of patients affected with rheumatic diseases. Materials and methods: indirect immunofluorescence on HEp-2000 cells at serum dilution of 1:40 was used to examin 26 sera which had previously showed a “mitotic spindle” fluoroscopic pattern type during laboratory routine. Results: 21 sera (80,7%) were identified with NuMA and 5 (19,3%) with HsEg5 patterns alone or associated with other ANA patterns. However only patients with isolated positiveness and that is 15 with NuMA and 4 with HsEg5 stainings were included in this study. Of the NuMA positive patients 5 were affected with arthropathies associated to different forms of thyroiditis, 2 with seronegative arthritis, 2 with antiphospholipid syndrome, 1 with systemic lupus erythematosus (SLE), 1 with rheumatoid arthritis, 1 with sicca syndrome, 1 with undifferentiated connective tissue disease, 1 with Mycoplasma pneumaniae infection and 1 with retinal thrombosis. Of the HsEg5 positive patients 3 were affected with SLE and 1 with seronegative arthritis. Conclusions: NuMA does not prevail in any defined rheumatic disease, while HsEg5 staining were more frequent (75%) in patients affected with SLE all of whom showing high antibody titres.

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How to Cite
Grypiotis, P., Ruffatti, A., Tonello, M., Winzler, C., Radu, C., Zampieri, S., Favaro, M., Calligaro, A., & Todesco, S. (1). Clinical significance of fluoroscopic patterns specific for the mitotic spindle in patients with reumatic diseases. Reumatismo, 54(3), 232-237. https://doi.org/10.4081/reumatismo.2002.232

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