Real-world experiences of folic acid supplementation (5 versus 30 mg/week) with methotrexate in rheumatoid arthritis patients: a comparison study

  • K.T. Koh Department of Medicine, Miri Hospital, Sarawak, Malaysia.
  • C.L. Teh | tehchenglay@yahoo.com Department of Medicine, Unit of Rheumatology, Sarawak General Hospital, Sarawak, Malaysia.
  • C.K. Cheah Department of Medicine, Tuanku Ja’afar Hospital, Seremban, NS, Malaysia.
  • G.R. Ling Department of Medicine, Unit of Rheumatology, Sarawak General Hospital, Sarawak, Malaysia.
  • M.C. Yong Department of Medicine, Unit of Rheumatology, Sarawak General Hospital, Sarawak, Malaysia.
  • H.C. Hong Department of Medicine, Tuanku Ja’afar Hospital, Seremban, NS, Malaysia.
  • S.C. Gun Department of Medicine, Tuanku Ja’afar Hospital, Seremban, NS, Malaysia.

Abstract

The objective of this study was to compare the tolerability of methotrexate in two different regimes of folic acid (FA) supplementation in rheumatoid arthritis (RA). We performed a multicenter, cross-sectional observational cohort study on 240 RA patients with 120 patients each in 5 mg of FA weekly and 30 mg of FA weekly supplementation. There were no significant differences for side effects (14.2 versus 22.5%, P=0.523) and discontinuation of methotrexate (3.6 versus 13.3%, P=0.085). RA patients given 5 mg of FA weekly supplementation had a lower disease activity score 28 compared to 30 mg of FA weekly supplementation [3.44 (1.10) versus 3.85 (1.40), P=0.014]. FA supplementation of 5 mg per week and 30 mg per week was associated with similar tolerability of methotrexate in RA patients.

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Published
2016-09-09
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Articles
Keywords:
Folic acid, methotrexate, rheumatoid arthritis, disease activity score 28, treatment regimes.
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How to Cite
Koh, K., Teh, C., Cheah, C., Ling, G., Yong, M., Hong, H., & Gun, S. (2016). Real-world experiences of folic acid supplementation (5 versus 30 mg/week) with methotrexate in rheumatoid arthritis patients: a comparison study. Reumatismo, 68(2), 90-96. https://doi.org/10.4081/reumatismo.2016.872