Influence of TNF-α inhibition on oxidative stress of rheumatoid arthritis patients

  • F. Cacciapaglia | f.cacciapaglia@unicampus.it Internal Medicine Unit and Rheumatology Clinic, N. Melli Hospital, San Pietro Vernotico (BR), Italy.
  • M.G. Anelli Interdisciplinary Department of Medicine, Rheumatology Unit, Medical School, University of Bari, Italy.
  • D. Rizzo Morelli & Di Pierro Lab, Squinzano (LE), Italy.
  • E. Morelli Morelli & Di Pierro Lab, Squinzano (LE), Italy.
  • C. Scioscia Interdisciplinary Department of Medicine, Rheumatology Unit, Medical School, University of Bari, Italy.
  • D. Mazzotta Internal Medicine Unit and Rheumatology Clinic, N. Melli Hospital, San Pietro Vernotico (BR), Italy.
  • F. Iannone Interdisciplinary Department of Medicine, Rheumatology Unit, Medical School, University of Bari, Italy.
  • G. Lapadula Interdisciplinary Department of Medicine, Rheumatology Unit, Medical School, University of Bari, Italy.

Abstract

The aim of this study was to assess circulating levels of reactive oxygen metabolites (ROMs) as a marker of oxidative stress in rheumatoid arthritis (RA) patients during an anti-tumor necrosis factor alpha (TNF-α) treatment. We enrolled 40 patients with RA (36 females; age 53±13 yrs) treated with different subcutaneously administered TNF-α inhibitors. The oxidative status was determined on the basis of plasma samples taken before, at 24 and 52 weeks of the anti-TNF-α treatment. Hydroperoxide levels were measured using the d-ROMs test, a useful clinically proven oxidative stress marker. During the anti-TNF-α therapy, we observed a significant reduction in serum ROMs levels in RA patients from 33.2±10 mg H2O2/L at baseline to 29.5±7 and 29.3±9 mg H2O2/L, at 24 and 52 weeks, respectively (p<0.05). We also identified a significant correlation between the oxidative stress status and the disease activity score on 28 joints/C-reactive protein and health assessment questionnaire disability index. The results of our study demonstrate that a good control of the disease with anti-TNF-α agents can reduce oxidative stress in RA patients. However, further studies of larger patient cohorts are needed to confirm these preliminary data.

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Published
2016-02-09
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Articles
Keywords:
Anti-TNF, oxidative stress, rheumatoid arthritis, reactive oxygen species.
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How to Cite
Cacciapaglia, F., Anelli, M., Rizzo, D., Morelli, E., Scioscia, C., Mazzotta, D., Iannone, F., & Lapadula, G. (2016). Influence of TNF-α inhibition on oxidative stress of rheumatoid arthritis patients. Reumatismo, 67(3), 97-102. https://doi.org/10.4081/reumatismo.2015.829