Polyarthritis flare in patient with ankylosing spondylitis treated with infliximab

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Over the last ten years, the treatment of seronegative spondyloarthropathies has changed dramatically with the introduction of the anti-tumor necrosis factor alpha (TNFα) agents. Nevertheless, there is a growing number of studies describing several adverse reactions in patients treated with biological agents. In the present report we describe the case of a 22-year-old male patient with ankylosing spondylitis who developed a “paradoxic” adverse reaction, while receiving infliximab.

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Gutierrez, M., Becciolini, A., Bertolazzi, C., Di Geso, L., Tardella, M., Ariani, A., Filippucci, E., & Grassi, W. (2010). Polyarthritis flare in patient with ankylosing spondylitis treated with infliximab. Reumatismo, 62(3), 221–224. https://doi.org/10.4081/reumatismo.2010.221