Antiphospholipid antibody: laboratory, pathogenesis and clinical manifestations

Abstract

Antiphospholipid antibodies (aPL) represent a heterogeneous group of antibodies that recognize various antigenic targets including beta2 glycoprotein I (β2GPI), prothrombin (PT), activated protein C, tissue plasminogen activator, plasmin and annexin A2. The most commonly used tests to detect aPL are: lupus anticoagulant (LAC), a functional coagulation assay, anticardiolipin antibody (aCL) and anti-β2GPI antibody (anti-β2GPI), which are enzyme-linked immunoassay (ELISA). Clinically aPL are associated with thrombosis and/or with pregnancy morbidity. Apparently aPL alone are unable to induce thrombotic manifestations, but they increase the risk of vascular events that can occur in the presence of another thrombophilic condition; on the other hand obstetrical manifestations were shown to be associated not only to thrombosis but mainly to a direct antibody effect on the trophoblast.

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How to Cite
Tincani, A., Casu, C., Cartella, S., Ziglioli, T., & Cattaneo, R. (1). Antiphospholipid antibody: laboratory, pathogenesis and clinical manifestations. Reumatismo, 62(1), 65-75. https://doi.org/10.4081/reumatismo.2010.65

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