Reviews
6 June 2025
Vol. 60 No. 2 (2008)
https://doi.org/10.4081/reumatismo.2008.85

Citrullination: the loss of tolerance and development of autoimmunity in rheumatoid arthritis

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Authors

S. Alivernini
office@pagepress.org
A.L. Fedele
I. Cuoghi
B. Tolusso
G. Ferraccioli
Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by synovial inflammation and pannus formation, which can lead to severe destruction of cartilage and bone. Several self proteins have been suggested to be disease-driving autoantigens. Moreover the presence of autoantibodies to citrullinated proteins in sera of patients with RA enhances the strength of this hypothesis. Proteins are encoded by a limited number of genes in our genome. Post-translational modifications such as phosphorylation, glycosylation and citrullination can increase the morphological and the functional diversity of the proteome.

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Citrullination: the loss of tolerance and development of autoimmunity in rheumatoid arthritis. (2008). Reumatismo, 60(2), 85-94. https://doi.org/10.4081/reumatismo.2008.85

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