Different fracture risk profile in patients treated with anti-osteoporotic drugs in real-life

Submitted: 3 December 2019
Accepted: 15 April 2020
Published: 23 July 2020
Abstract Views: 1346
PDF: 977
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In this retrospective study, we intended to investigate the baseline fracture risk profile in patients who started treatment with different anti-osteoporotic medications. We analyzed retrospectively the fracture risk calculated with DeFRA, a validated FRAX derived tool, in women who started an anti-osteoporotic treatment from 2010 to 2017. We analyzed baseline data of 12,024 post-menopausal women aged over 50 years. Teriparatide initiators had a baseline 10-year risk of major osteoporotic fracture of 82.1% with a Standard Deviation (SD) of 66.5%. Denosumab initiators and zoledronic acid initiators had a greater 10-year baseline risk of fracture (54.3%, SD 46.5% and 47.0%, SD 42.0 respectively) than patients initiated on alendronate (24.9%, SD 34.6%) and patients initiated on risedronate (23.9%, SD 24.1%). Using DeFRA, a FRAX™ derived tool, we showed significantly different fracture risk profiles in women who were started on various therapeutic agents for the treatment of osteoporosis in routine clinical practice.

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Adami, G., Giollo, A., Rossini, M., Orsolini, G., Benini, C., Viapiana, O., … Fassio, A. (2020). Different fracture risk profile in patients treated with anti-osteoporotic drugs in real-life. Reumatismo, 72(2), 71–74. https://doi.org/10.4081/reumatismo.2020.1267

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