Novel autoantibodies in rheumatoid arthritis

  • A.F. Bonifacio Rheumatology Unit, Department of Medicine, University of Perugia, Italy.
  • A. Alunno Rheumatology Unit, Department of Medicine, University of Perugia, Italy.
  • G.M.C. La Paglia Rheumatology Unit, Department of Medicine, University of Perugia, Italy.
  • E. Valentini Rheumatology Unit, Department of Medicine, University of Perugia, Italy.
  • M.C. Leone Rheumatology Unit, Department of Medicine, University of Perugia, Italy.
  • E. Bartoloni Rheumatology Unit, Department of Medicine, University of Perugia, Italy.
  • Roberto Gerli | roberto.gerli@unipg.it Rheumatology Unit, Department of Medicine, University of Perugia, Italy.

Abstract

Rheumatoid factor and antibodies against cyclic citrullinated peptides represent a diagnostic hallmark in rheumatoid arthritis (RA). However, over the last decades many other autoantibodies have been identified. Several proteins can trigger an aberrant autoimmune response in their native form while others acquire this feature after post-translational modifications such as citrullination, carbamylation or acetylation. It is of interest that also the enzymes catalyzing such post-translational modifications (e.g. the protein arginine deiminases) can transform themselves into autoantibodies in RA. The purpose of this review article is to provide an overview of relevant literature published over the last years regarding novel autoantibodies and their possible diagnostic and prognostic significance in RA.

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Published
2019-04-01
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Issue
Section
Reviews
Keywords:
Rheumatoid arthritis, Autoantibodies, Citrullination.
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  • PDF: 813
How to Cite
Bonifacio, A., Alunno, A., La Paglia, G., Valentini, E., Leone, M., Bartoloni, E., & Gerli, R. (2019). Novel autoantibodies in rheumatoid arthritis. Reumatismo, 71(1), 1-12. https://doi.org/10.4081/reumatismo.2019.1102

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