Demyelinating syndrome in SLE: review of different disease subtypes and report of a case series

Submitted: 5 May 2017
Accepted: 4 August 2017
Published: 21 December 2017
Abstract Views: 2340
PDF: 1408
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Demyelinating syndrome (DS) is a rare manifestation of systemic lupus erythematosus (SLE) (1%) with high clinical heterogeneity and potentially severe prognosis. It can represent a diagnostic and therapeutic challenge for clinicians. A recent study described 5 different patterns of demyelinating disease presentation, characterised by specific clinical, laboratory and brain and spine magnetic resonance imaging abnormalities: 1) neuromyelitis optica; 2) neuromyelitis optica spectrum disorders; 3) DS prevalently involving the brain; 4) DS prevalently involving the brainstem; 5) clinically isolated syndrome. In this review we briefly discuss typical characteristics of each DS presentation in SLE and we describe 5 illustrative clinical cases, one for each subset of DS, considering both diagnostic and therapeutic options.

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Chessa, E., Piga, M., Floris, A., Mathieu, A., & Cauli, A. (2017). Demyelinating syndrome in SLE: review of different disease subtypes and report of a case series. Reumatismo, 69(4), 175–183. https://doi.org/10.4081/reumatismo.2017.1007