Demyelinating syndrome in SLE: review of different disease subtypes and report of a case series

  • E. Chessa | elis.chessa@gmail.com Rheumatology Unit, University Clinic AOU of Cagliari, Italy.
  • M. Piga Rheumatology Unit, University Clinic AOU of Cagliari, Italy.
  • A. Floris Rheumatology Unit, University Clinic AOU of Cagliari, Italy.
  • A. Mathieu Rheumatology Unit, University Clinic AOU of Cagliari, Italy.
  • A. Cauli Rheumatology Unit, University Clinic AOU of Cagliari, Italy.

Abstract

Demyelinating syndrome (DS) is a rare manifestation of systemic lupus erythematosus (SLE) (1%) with high clinical heterogeneity and potentially severe prognosis. It can represent a diagnostic and therapeutic challenge for clinicians. A recent study described 5 different patterns of demyelinating disease presentation, characterised by specific clinical, laboratory and brain and spine magnetic resonance imaging abnormalities: 1) neuromyelitis optica; 2) neuromyelitis optica spectrum disorders; 3) DS prevalently involving the brain; 4) DS prevalently involving the brainstem; 5) clinically isolated syndrome. In this review we briefly discuss typical characteristics of each DS presentation in SLE and we describe 5 illustrative clinical cases, one for each subset of DS, considering both diagnostic and therapeutic options.

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Published
2017-12-21
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Articles
Keywords:
Systemic lupus erythematosus, Demyelinating syndrome, Neuropsychiatric lupus, Magnetic resonance.
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How to Cite
Chessa, E., Piga, M., Floris, A., Mathieu, A., & Cauli, A. (2017). Demyelinating syndrome in SLE: review of different disease subtypes and report of a case series. Reumatismo, 69(4), 175-183. https://doi.org/10.4081/reumatismo.2017.1007