Secondary hemophagocytic lymphohistiocytosis possibly induced by interferon beta-1a therapy.

Submitted: 9 September 2013
Accepted: 7 November 2013
Published: 18 December 2013
Abstract Views: 2798
PDF: 679
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A 57-year old woman with a history of multiple sclerosis, treated with interferon beta-1a in the last 5 months, was referred for hyperpyrexia (>40°C) that persisted for 15 days. At admission, there was elevation of transaminases, anemia (hemoglobin 8.9 g/dL), thrombocytopenia (platelet 135,000/mm3), and hypofibrinogenemia (fibrinogen 1.26 g/L). C-reactive protein was 10.7 mg/dL, lactate dehydrogenase 1270 U/L and ferritin 2380 ng/ mL, with hepatosplenomegaly and linfoadenomegaly. Hemophagocytic lymphohistiocytosis induced by direct stimulation of macrophages by interferon (IFN) was suspected. IFN was withdrawn as only measure and onemonth later signs and symptoms disappeared, with complete normalization of laboratory examinations.

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Cosso, C., Cosso, R., & Cimmino, M. (2013). Secondary hemophagocytic lymphohistiocytosis possibly induced by interferon beta-1a therapy. Reumatismo, 65(5), 253–255. https://doi.org/10.4081/reumatismo.2013.253